BONESMASHING
Highest ROI softmax?
After reading several threads of absolute brain rot—especially the horrible and idiotic thread by Jonas, "The truth about steroids and peptides affecting bones and height" (JFL at that bullshit being in BOTB) —along with various opinions from other people lacking any critical thinking skills, I decided to make this thread focusing on the following points:
1-How it works.
2-Subperiosteal hematomas and its impossibility as a consistent theory.
(Suck it seif)
3-Bone homeostasis.
This thread assumes that bonesmashing works, and will focus on explaining how.
THREAD SONG:
How it works:
Bonesmashing works through the
Wnt/β-catenin axis and
sclerostin
As you may have read, mechanotransduction is essential for regulating bone homeostasis and shifting it toward the growth process rather than the resorption process. Sclerostin, whose expression increases with a lack of mechanical load, that inhibits the Wnt/β-catenin pathway.
The role of the Wnt/β-catenin pathway in mechanotransduction.
The
Wnt/β-catenin pathway through the downregulation of sclerostin via mechanotransduction. The Wnt/β-catenin pathway leads to osteoanabolic processes through osteoblastogenesis, promoting mesenchymal stem cells to differentiate into osteoblasts, resulting in their proliferation over osteoclasts.
This pathway also upregulates BMP-2, one of the most potent bone growth factor.
Nitric oxide release and its role in the sclerostin and Wnt/β-catenin axis.
Mechanical bone loading causes osteocytes to release nitric oxide, which rapidly degrades sclerostin which also further increases Wnt/β-catenin.
[8]In response to mechanical loading of bone,
osteocytes produce
nitric oxide (NO) and decrease
sclerostin protein expression, leading to an increase in bone mass.
Subperiosteal hematoma theory
I’m not going to spend much time on this point since I developed a fairly detailed response at the time, which I will now quote.
Bone homeostasis and Growth factors
Contrary to my previous belief that the results of bonesmashing were limited without the use of exogenous growth factors such as rHGH, sex hormones or their derivatives, and parathyroid hormone analogs, the
Wnt/β-catenin pathway is one of the main regulators of bone homeostasis. By being upregulated through mechanotransduction, this pathway could produce noticeable results solely through proper bonesmashing technique and application, and synergize as well as greatly amplify the aforementioned factors.
Tl;dnr: Start bonesmashing rn!!!!
Tags:
Dexter
birthdefect