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Theory Mechanotransductio, bonesmashing full science breakdown and theories (9 Viewers)

Theory Mechanotransductio, bonesmashing full science breakdown and theories

Tabula Rasa

Le Fort II Candidate
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So he had one bad experience? This doesn't prove it's a bad lM & worse than muh bonesmashing.
No but it's not a fucking side quest, just do it bro.
I feel like you don’t have a debunk
I’ve invested in this debate bro don’t make daddy lose now
Also, you still haven't debunked me; I'm waiting
I can't debunk a false premise. Give me examples of your claims. "The mechanism is under lab-controled conditions with precise force applied" Well tell me were and which forces.
 

Circadex

The real "child of renaissance"
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No but it's not a fucking side quest, just do it bro.
No LM is a side quest; what's your point?

I can't debunk a false premise. Give me examples of your claims. "The mechanism is under lab-controled conditions with precise force applied" Well tell me where and which forces.
What? It shouldn't take a linked source and/or example to prove studys use precise methods & ensure controlled environment
 

Razi

Lamecel
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IMG_0678.jpeg

Will bonesmashing help him?
 
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BONESMASHING
Highest ROI softmax?

After reading several threads of absolute brain rot—especially the horrible and idiotic thread by Jonas, "The truth about steroids and peptides affecting bones and height" (JFL at that bullshit being in BOTB) —along with various opinions from other people lacking any critical thinking skills, I decided to make this thread focusing on the following points:
1-How it works.
2-Subperiosteal hematomas and its impossibility as a consistent theory.
(Suck it seif)
3-Bone homeostasis.



This thread assumes that bonesmashing works, and will focus on explaining how.

THREAD SONG:


How it works:

Bonesmashing works through the Wnt/β-catenin axis and sclerostin

As you may have read, mechanotransduction is essential for regulating bone homeostasis and shifting it toward the growth process rather than the resorption process. Sclerostin, whose expression increases with a lack of mechanical load, that inhibits the Wnt/β-catenin pathway.


The role of the Wnt/β-catenin pathway in mechanotransduction.
The Wnt/β-catenin pathway through the downregulation of sclerostin via mechanotransduction. The Wnt/β-catenin pathway leads to osteoanabolic processes through osteoblastogenesis, promoting mesenchymal stem cells to differentiate into osteoblasts, resulting in their proliferation over osteoclasts.
This pathway also upregulates BMP-2, one of the most potent bone growth factor.



Nitric oxide release and its role in the sclerostin and Wnt/β-catenin axis.
Mechanical bone loading causes osteocytes to release nitric oxide, which rapidly degrades sclerostin which also further increases Wnt/β-catenin.[8]In response to mechanical loading of bone, osteocytes produce nitric oxide (NO) and decrease sclerostin protein expression, leading to an increase in bone mass.

Subperiosteal hematoma theory
I’m not going to spend much time on this point since I developed a fairly detailed response at the time, which I will now quote.


Bone homeostasis and Growth factors

Contrary to my previous belief that the results of bonesmashing were limited without the use of exogenous growth factors such as rHGH, sex hormones or their derivatives, and parathyroid hormone analogs, the Wnt/β-catenin pathway is one of the main regulators of bone homeostasis. By being upregulated through mechanotransduction, this pathway could produce noticeable results solely through proper bonesmashing technique and application, and synergize as well as greatly amplify the aforementioned factors.


Tl;dnr: Start bonesmashing rn!!!!

Tags:
Dexter Dexter birthdefect birthdefect
this is a cope cope
 

Tabula Rasa

Le Fort II Candidate
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I know i mind broke you with my IQ it's ok. Just say im right, ask mods to remove & move on. If you want to prove your point you're more than welcome to attempt a debunk

anyways your seething nature is a dead-giveaway you're overwhelmed & scared you're wrong. I approached this convo with the exception of an genuine debate, but nah you're too maldy
Shut your reddit corny ass bro. I can say that this is intellectual dishonesty but i rather said is retardation.
No LM is a side quest; what's your point?


What? It shouldn't take a linked source and/or example to prove studys use precise methods & ensure controlled environment
Waiting for examples.
 

goyboy.hero

Superhero of the goys
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see scientifically it does make sense but in practicality i doubt any meaningful results will be seen
i will try posting x rays on here in july, either proving/disproving bonesmashing
Even if it works, I'm not getting a potential concussion or walking around places with giant bruises on my face
 

Circadex

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Shut your reddit corny ass bro. I can say that this is intellectual dishonesty but i rather said is retardation.
Battle of the ad hominems who will win??


Waiting for examples.
I don't need an example. This is common sense, you're like some half-wit who asks for "source saaar" when confronted with something like "the sky is blue", "grass is green".
I don't think you understand what you're even saying; if i was wrong, you'd be admitting your citations use poorly-controlled procedure to gauge results
 

Razi

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I don't need an example. This is common sense, you're like some half-wit who asks for "source saaar" when confronted with something like "the sky is blue", "grass is green".
I don't think you understand what you're even saying; if i was wrong, you'd be admitting your citations use poorly-controlled procedure to gauge results
Yeh no need to quote me circy next time I’ll feed you your own hands
 

Circadex

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There is no ad hominem in calling someone retard, ad hominem is saying your argument is invalid beacuse you are retard.
ad hominem = attacking someones character rather than the argument presented (E.g., "shut your reddit corny ass up")
 

Synapse

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First of all glad that finally someone decided to call jonas for that bs, second of all, it has an interesting mechanism, the issue here is the lack of any study for this, but i guess that is a terrible argument as for many steroids that people use a lot (like tren), the best we have is extrapolated animal studies data rather than any real good human quality data, so saying that would just be not being open to exploring the theory and mechanism about it, however, even if the mechanism is legit and it works, i still think fillers are more convenient, actually surgerymax surgerymax and i talked about it, but it was mainly about how this could work but not as gaining real raw bone but rather scar tissue, and how could compounds that supercharge collagen synthesis like winnie and other could increase the effectiveness of this, it's an interesting topic, but imo fillers are still the most convenient and fastest option for instant results.
 

Circadex

The real "child of renaissance"
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First of all glad that finally someone decided to call jonas for that bs, second of all, it has an interesting mechanism, the issue here is the lack of any study for this, but i guess that is a terrible argument as for many steroids that people use a lot (like tren), the best we have is extrapolated animal studies data rather than any real good human quality data, so saying that would just be not being open to exploring the theory and mechanism about it, however, even if the mechanism is legit and it works, i still think fillers are more convenient, actually surgerymax surgerymax and i talked about, but it was mainly about how this could work but not as gaining real raw bone but rather scar tissue, and how could compounds that supercharge collagen synthesis like winnie and other could increase the effectiveness of this, it's an interesting topic, but imo fillers are still the most convenient and fastest option for instant results.
It doesn't matter. The theory it's self is flawed
 

Razi

Lamecel
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First of all glad that finally someone decided to call jonas for that bs, second of all, it has an interesting mechanism, the issue here is the lack of any study for this, but i guess that is a terrible argument as for many steroids that people use a lot (like tren), the best we have is extrapolated animal studies data rather than any real good human quality data, so saying that would just be not being open to exploring the theory and mechanism about it, however, even if the mechanism is legit and it works, i still think fillers are more convenient, actually surgerymax surgerymax and i talked about it, but it was mainly about how this could work but not as gaining real raw bone but rather scar tissue, and how could compounds that supercharge collagen synthesis like winnie and other could increase the effectiveness of this, it's an interesting topic, but imo fillers are still the most convenient and fastest option for instant results.
What abt hard mewing tho?
 

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