Theory Mechanotransductio, bonesmashing full science breakdown and theories (4 Viewers)

[Tabula Rasa]

BONESMASHING
Highest ROI softmax?

After reading several threads of absolute brain rot—especially the horrible and idiotic thread by Jonas, "The truth about steroids and peptides affecting bones and height" (JFL at that bullshit being in BOTB) —along with various opinions from other people lacking any critical thinking skills, I decided to make this thread focusing on the following points:
1-How it works.
2-Subperiosteal hematomas and its impossibility as a consistent theory.
(Suck it seif)
3-Bone homeostasis.


This thread assumes that bonesmashing works, and will focus on explaining how.

THREAD SONG:

How it works:

Bonesmashing works through the Wnt/β-catenin axis and sclerostin​

[1]
"Reduced mechanical stress leads to bone loss, as evidenced by disuse osteoporosis in bedridden patients and astronauts. Osteocytes have been identified as major cells responsible for mechanotransduction; however, the mechanism underlying the response of bone to mechanical unloading remains poorly understood. In this study, we found that mechanical unloading of wildtype mice caused decrease of Wnt/beta-catenin signaling activity accompanied by upregulation of Sost."
[2]
"The loss of the SOST gene product sclerostin leads to sclerosteosis characterized by high bone mass. In this report, we found that sclerostin could antagonize canonical Wnt signaling in human embryonic kidney A293T cells and mouse osteoblastic MC3T3 cells."
[3]
"Mechanical stimulation reduces sclerostin expression, suggesting that osteocytes might coordinate the osteogenic response to mechanical force by locally unleashing Wnt signaling."
"Thus, downregulation of Sost/sclerostin in osteocytes is an obligatory step in the mechanotransduction cascade that activates Wnt signaling and directs osteogenesis to where bone is structurally needed."
[4]
"We investigated the mechanoregulation of Sost and sclerostin under enhanced (ulnar loading) and reduced (hindlimb unloading) loading conditions. Sost transcripts and sclerostin protein levels were dramatically reduced by ulnar loading. Portions of the ulnar cortex receiving a greater strain stimulus were associated with a greater reduction in Sost staining intensity and sclerostin-positive osteocytes (revealed via in situ hybridization and immunohistochemistry, respectively) than were lower strain portions of the tissue. Hindlimb unloading yielded a significant increase in Sost expression in the tibia."​

As you may have read, mechanotransduction is essential for regulating bone homeostasis and shifting it toward the growth process rather than the resorption process. Sclerostin, whose expression increases with a lack of mechanical load, that inhibits the Wnt/β-catenin pathway.


The role of the Wnt/β-catenin pathway in mechanotransduction.
The Wnt/β-catenin pathway through the downregulation of sclerostin via mechanotransduction. The Wnt/β-catenin pathway leads to osteoanabolic processes through osteoblastogenesis, promoting mesenchymal stem cells to differentiate into osteoblasts, resulting in their proliferation over osteoclasts.
This pathway also upregulates BMP-2, one of the most potent bone growth factor.
​

[5]
4. Importance of the Wnt/β-catenin pathway in bone formation and maintenance
"During the early stages of fracture repair, β-catenin is required for pluripotent mesenchymal cells to differentiate into either osteoblasts or chondrocytes and in later stages of repair for preosteoblasts to differentiate into osteoblasts."
"In the postnatal and mature skeleton, the Wnt/β-catenin signaling pathway is essential for bone mass maintenance by regulating the activity of the bone-forming osteoblasts and indirectly, the bone-resorbing osteoclasts"
[6]
https://pubmed.ncbi.nlm.nih.gov/23401003/
"The deduced direct negative influence of canonical Wnt signaling on osteoclastogenesis was confirmed in vitro and through the generation of mice lacking β-catenin in the osteoclast lineage."

[7]
However, Wnt3a also enhanced BMP/Smad reporter activity (Fig. 2A), indicating that activation of Wnt signaling cross-stimulates BMP signaling.

​

Nitric oxide release and its role in the sclerostin and Wnt/β-catenin axis.
Mechanical bone loading causes osteocytes to release nitric oxide, which rapidly degrades sclerostin which also further increases Wnt/β-catenin.[8]In response to mechanical loading of bone, osteocytes produce nitric oxide (NO) and decrease sclerostin protein expression, leading to an increase in bone mass.

Subperiosteal hematoma theory
I’m not going to spend much time on this point since I developed a fairly detailed response at the time, which I will now quote.​

1- You cannot prove that your bonesmashing technique produces subperiosteal hematomas, and given that this is a rare condition, it’s naive to assume that a self-inflicted trauma would produce it, much less produce it consistently.
2- Most subperiosteal hematomas do not ossify, and many factors are required for that process to occur.
3- Subperiosteal hematomas, tend to expand; to achieve aesthetic augmentation you would need consistent blood pooling across the entire bone you want to augmentate, which you are not going to achieve, let alone trigger a process of ossification.
In other words, it's playing with small possibilities within other small possibilities, within infinitesimal possibilities. A doll of impossibility, which makes its consistency impossible.

Bone homeostasis and Growth factors​

[8]
Wnt signaling regulates bone homeostasis by modulating the biological function of bone cells, including BM-MSCs, osteoblasts, osteoclasts, and osteocytes. The canonical Wnt signaling promotes bone formation, inhibits bone resorption and adipocyte differentiation during maintaining bone homeostasis. When canonical Wnt signaling is activated by Wnts binding to the receptors or by the activators of Wnt signaling (e.g., RSpo, Norrin, and MACF1), β-catenin accumulates in the cytoplasm and translocates into the nucleus to regulate the target gene expression in bone cells to control bone cell capacity.​

Contrary to my previous belief that the results of bonesmashing were limited without the use of exogenous growth factors such as rHGH, sex hormones or their derivatives, and parathyroid hormone analogs, the Wnt/β-catenin pathway is one of the main regulators of bone homeostasis. By being upregulated through mechanotransduction, this pathway could produce noticeable results solely through proper bonesmashing technique and application, and synergize as well as greatly amplify the aforementioned factors.


Tl;dnr: Start bonesmashing rn!!!!

Tags:
Dexter birthdefect
​

 

[Razi]

I really like the colors nice work

 

[Hexum]

BONESMASHING
Highest ROI softmax?

After reading several threads of absolute brain rot—especially the horrible and idiotic thread by Jonas, "The truth about steroids and peptides affecting bones and height"(JFL at this bullshit being in BOTB)—along with various opinions from other people lacking any critical thinking skills, I decided to make this thread focusing on the following points:
1-How it works.
2-Subperiosteal hematomas and its impossibility as a consistent theory.
(Suck it seif)
3-Bone homeostasis.


This thread assumes that bonesmashing works, and will focus on explaining how.

THREAD SONG:
View: https://www.youtube.com/watch?v=sPmSO0isjic&list=RDsPmSO0isjic&start_radio=1


How it works:

Bonesmashing works through the Wnt/β-catenin axis and sclerostin

As you may have read, mechanotransduction is essential for regulating bone homeostasis and shifting it toward the growth process rather than the resorption process. Sclerostin, whose expression increases with a lack of mechanical load, that inhibits the Wnt/β-catenin pathway.


The role of the Wnt/β-catenin pathway in mechanotransduction.
The Wnt/β-catenin pathway through the downregulation of sclerostin via mechanotransduction. The Wnt/β-catenin pathway leads to osteoanabolic processes through osteoblastogenesis, promoting mesenchymal stem cells to differentiate into osteoblasts, resulting in their proliferation over osteoclasts.
This pathway also upregulates BMP-2, one of the most potent bone growth factor.



Nitric oxide release and its role in the sclerostin and Wnt/β-catenin axis.
Mechanical bone loading causes osteocytes to release nitric oxide, which rapidly degrades sclerostin which also further increases Wnt/β-catenin.[8]In response to mechanical loading of bone, osteocytes produce nitric oxide (NO) and decrease sclerostin protein expression, leading to an increase in bone mass.

Subperiosteal hematoma theory
I’m not going to spend much time on this point since I developed a fairly detailed response at the time, which I will now quote.


Bone homeostasis and Growth factors

Contrary to my previous belief that the results of bonesmashing were limited without the use of exogenous growth factors such as rHGH, sex hormones or their derivatives, and parathyroid hormone analogs, the Wnt/β-catenin pathway is one of the main regulators of bone homeostasis. By being upregulated through mechanotransduction, this pathway could produce noticeable results solely through proper bonesmashing technique and application, and synergize as well as greatly amplify the aforementioned factors.


Tl;dnr: Start bonesmashing rn!!!!

Tags:
Dexter birthdefect
​

DNR

 

[bob08674]

Who did u copy this from?

 

[Dexter]

see scientifically it does make sense but in practicality i doubt any meaningful results will be seen
i will try posting x rays on here in july, either proving/disproving bonesmashing

 

[Razi]

see scientifically it does make sense but in practicality i doubt any meaningful results will be seen
i will try posting x rays on here in july, either proving/disproving bonesmashing

I hope it disprove it I don’t want to do it if it worked it hurts and too much work

 

[Tabula Rasa]

I really like the colors nice work

Thanks buddy boyo

DNR

Ok

Who did u copy this from?

From pubmed mainly

see scientifically it does make sense but in practicality i doubt any meaningful results will be seen
i will try posting x rays on here in july, either proving/disproving bonesmashing

What is your exact protocol and and how much time are you going to give it?

I hope it disprove it I don’t want to do it if it worked it hurts and too much work

Blackpill overdose!!!

 

[birthdefect]

BONESMASHING
Highest ROI softmax?

After reading several threads of absolute brain rot—especially the horrible and idiotic thread by Jonas, "The truth about steroids and peptides affecting bones and height" (JFL at that bullshit being in BOTB) —along with various opinions from other people lacking any critical thinking skills, I decided to make this thread focusing on the following points:
1-How it works.
2-Subperiosteal hematomas and its impossibility as a consistent theory.
(Suck it seif)
3-Bone homeostasis.


This thread assumes that bonesmashing works, and will focus on explaining how.

THREAD SONG:

How it works:

Bonesmashing works through the Wnt/β-catenin axis and sclerostin

As you may have read, mechanotransduction is essential for regulating bone homeostasis and shifting it toward the growth process rather than the resorption process. Sclerostin, whose expression increases with a lack of mechanical load, that inhibits the Wnt/β-catenin pathway.


The role of the Wnt/β-catenin pathway in mechanotransduction.
The Wnt/β-catenin pathway through the downregulation of sclerostin via mechanotransduction. The Wnt/β-catenin pathway leads to osteoanabolic processes through osteoblastogenesis, promoting mesenchymal stem cells to differentiate into osteoblasts, resulting in their proliferation over osteoclasts.
This pathway also upregulates BMP-2, one of the most potent bone growth factor.



Nitric oxide release and its role in the sclerostin and Wnt/β-catenin axis.
Mechanical bone loading causes osteocytes to release nitric oxide, which rapidly degrades sclerostin which also further increases Wnt/β-catenin.[8]In response to mechanical loading of bone, osteocytes produce nitric oxide (NO) and decrease sclerostin protein expression, leading to an increase in bone mass.

Subperiosteal hematoma theory
I’m not going to spend much time on this point since I developed a fairly detailed response at the time, which I will now quote.


Bone homeostasis and Growth factors

Contrary to my previous belief that the results of bonesmashing were limited without the use of exogenous growth factors such as rHGH, sex hormones or their derivatives, and parathyroid hormone analogs, the Wnt/β-catenin pathway is one of the main regulators of bone homeostasis. By being upregulated through mechanotransduction, this pathway could produce noticeable results solely through proper bonesmashing technique and application, and synergize as well as greatly amplify the aforementioned factors.


Tl;dnr: Start bonesmashing rn!!!!

Tags:
Dexter birthdefect
​

agreed on jonas' thread, utter dogshit
doesnt even say a word
will read thread tmr

 

[Circadex]

Such good formatting wasted on such a terrible topic. Bonesmashing is cope; it's all theory work & peddled by jesters. Even if it worked, your results will take  years of consistent "smashing", be hard to control, and risk unwanted injury.

Just get filler or surgery. Anyways make some more valuable threads — your formating isn't eye-rape like 99% of the cretins on here

 

[Persona]

Beautiful formatting, mirin.

 

[Tabula Rasa]

Such good formatting wasted on such a terrible topic. Bonesmashing is cope; it's all theory work & peddled by jesters. Even if it worked, your results will take  years of consistent "smashing", be hard to control, and risk unwanted injury.

Just get filler or surgery. Anyways make some more valuable threads — your formating isn't eye-rape like 99% of the cretins on here

along with various opinions from other people lacking any critical thinking skills, I decided to make this thread focusing on the following points:​

Do you even know why you say the things you say? You can't even back up your reply with consistent logical arguments. They're just plain affirmations. Why would take years? Why would not work?
"Just get surgery or fillers!!!"
Yeah, as if it's some casual thing to do after school.​

Beautiful formatting, mirin.

Thank you.

​

 

[Circadex]

Do you even know why you say the things you say? You can't even back up your reply with consistent logical arguments. They're just plain affirmations.
"Just get surgery or fillers!!!"
Yeah, as if it's some casual thing to do after school​

Well, it quite literally is. Multiple people on this forum alone have attempted & succeeded in DIY filler.

And yes i can back it up: The mechanism is under lab-controled conditions with precise force applied. Smashing your face with an object isn't comparable at-all. It's just cope

Why you bother even looking into this is far beyond me. And anyways, even if it worked, you cannot control how your bones will "grow" in. You'd be guaranteed to get asymmetrical results under anything that isn't precisely done by professionals.
Heterotopic ossification is just retarded; don't bonemash

 

[hideandseek]

BONESMASHING
Highest ROI softmax?

After reading several threads of absolute brain rot—especially the horrible and idiotic thread by Jonas, "The truth about steroids and peptides affecting bones and height" (JFL at that bullshit being in BOTB) —along with various opinions from other people lacking any critical thinking skills, I decided to make this thread focusing on the following points:
1-How it works.
2-Subperiosteal hematomas and its impossibility as a consistent theory.
(Suck it seif)
3-Bone homeostasis.


This thread assumes that bonesmashing works, and will focus on explaining how.

THREAD SONG:

How it works:

Bonesmashing works through the Wnt/β-catenin axis and sclerostin

As you may have read, mechanotransduction is essential for regulating bone homeostasis and shifting it toward the growth process rather than the resorption process. Sclerostin, whose expression increases with a lack of mechanical load, that inhibits the Wnt/β-catenin pathway.


The role of the Wnt/β-catenin pathway in mechanotransduction.
The Wnt/β-catenin pathway through the downregulation of sclerostin via mechanotransduction. The Wnt/β-catenin pathway leads to osteoanabolic processes through osteoblastogenesis, promoting mesenchymal stem cells to differentiate into osteoblasts, resulting in their proliferation over osteoclasts.
This pathway also upregulates BMP-2, one of the most potent bone growth factor.



Nitric oxide release and its role in the sclerostin and Wnt/β-catenin axis.
Mechanical bone loading causes osteocytes to release nitric oxide, which rapidly degrades sclerostin which also further increases Wnt/β-catenin.[8]In response to mechanical loading of bone, osteocytes produce nitric oxide (NO) and decrease sclerostin protein expression, leading to an increase in bone mass.

Subperiosteal hematoma theory
I’m not going to spend much time on this point since I developed a fairly detailed response at the time, which I will now quote.


Bone homeostasis and Growth factors

Contrary to my previous belief that the results of bonesmashing were limited without the use of exogenous growth factors such as rHGH, sex hormones or their derivatives, and parathyroid hormone analogs, the Wnt/β-catenin pathway is one of the main regulators of bone homeostasis. By being upregulated through mechanotransduction, this pathway could produce noticeable results solely through proper bonesmashing technique and application, and synergize as well as greatly amplify the aforementioned factors.


Tl;dnr: Start bonesmashing rn!!!!

Tags:
Dexter birthdefect
​

 

[Tabula Rasa]

Well, it quite literally is. Multiple people on this forum alone have attempted & succeeded in DIY filler.

That's why Orka had to dissolve his chin filler in less than a month.

And yes i can back it up: The mechanism is under lab-controled conditions with precise force applied. Smashing your face with an object isn't comparable at-all. It's just cope

Why you bother even looking into this is far beyond me. And anyways, even if it worked, you cannot control how your bones will "grow" in. You'd be guaranteed to get asymmetrical results under anything that isn't precisely done by professionals.
Heterotopic ossification is just retarded; don't bonemash

JFLLLLLLLL you haven't read a single study.

 

[Razi]

That's why Orka's chin filler dissolved in less than a month.


JFLLLLLLLL you haven't read a single study.

Yoooo go easy on him tabula go easy on him tabula
And make a response instead of saying he didn’t read I believe In you

 

[Circadex]

That's why Orka had to dissolve his chin filler in less than a month

elaborate

JFLLLLLLLL you haven't read a single study.

Mirin high-effort debunk

 

[Skulloute]

I like the formatting and colors. But the topic, hmmm?

 

[Razi]

I like the formatting and colors. But the topic, hmmm?

I didn’t even read I just stared at the head titles

 

[Skulloute]

I didn’t even read I just stared at the head titles

Gives me dopamine I can't lie

 

[Tabula Rasa]

elaborate

31/01/2026
Orka here, I do not recommend Revolax Deep anymore. I used it for this but my results quickly faded. Do your own research into filler types & brands and don't take advice blindly.
I will be using medeyra shape for my next chin session after dissolving this.
20/02/2026
I have gotten several dms regarding this guide.
The updated guide you are reading is exclusive to .gg, and has updated segments which were not mentioned on other forums.
I've ordered more filler to do more on my chin, and I'll make another guide once I successfully inject my jaw.

Mirin high-effort debunk

There is nothing to debunk you are just retarded and you haven't read any of the sources.

 

[Razi]

There is nothing to debunk you are just retarded and you haven't read any of the sources.

Nah mane crazy ad hom he’s gonna rape you for this response

 

[Circadex]

There is nothing to debunk you are just retarded and you haven't read any of the sources.

So he had one bad experience? This doesn't prove it's a bad lM & worse than muh bonesmashing.

Also, you still haven't debunked me; I'm waiting

Nah mane crazy ad hom he’s gonna rape you for this response

Take a moment to wonder why

 

[Tabula Rasa]

Nah mane crazy ad hom he’s gonna rape you for this response

He's indeed retard

 

[Razi]

He's indeed retard

I feel like you don’t have a debunk
I’ve invested in this debate bro don’t make daddy lose now

 

[Circadex]

He's indeed retard

I know i mind broke you with my IQ it's ok. Just say im right, ask mods to remove & move on. If you want to prove your point you're more than welcome to attempt a debunk

anyways your seething nature is a dead-giveaway you're overwhelmed & scared you're wrong. I approached this convo with the exception of an genuine debate, but nah you're too maldy