The truth about erdafitinib not being able to be ran safely (2 Viewers)

[fent]

Hello all, quick thread debunking "erda cannot be ran safely" due to hyperphosphetamia + retinal issues, in this thread i will be debunking this. (i cant do spoilers for some reason so forgive me)

The proposed flaw
" phosphate binders like sevelamer don't actually solve the phosphate problem people think they do. Sevelamer only blocks phosphate absorption in your gut it does nothing about the kidneys reabsorbing phosphate internally, which is the actual thing erdafitinib disrupts. From what I can tell, the only real mitigation oncologists use is dose reduction/interruption based on labs. The retinal and calcification stuff doesn't seem to be something you can supplement your way around, since it's tied directly to the drug's mechanism rather than being a separate side effect."

Why this isnt the same in reality
To induce calcification that their claiming you would need to remain in this state for several months to even years the claim that its done within 7-11 days is fabricated, moreover sevelamer WOULD help and due to how long it hyperphosphetamia needs to be maintained its the reason why low dose + ancillaries + cycling is ideal.

Proposed flaw 2
Eye issues induced by erdafitinib.

Why this isnt the same in reality
20% of users on 8-9mg experienced eye issues which is AGAIN why low dose + ancillaries + cycling is ideal.
Futhermore in studies, 63-65% of cases patients achieve complete resolution of drug-induced retinopathy and for the others they mostly suffered grade 1 symptoms which are very mild .
In another RAGNAR trial, 92% of patients had their visual acuity return completely to baseline

STOP FEARMONGERING ERDAFITINIB
@orbitex @thuuk @guilty

 

[fent]

@Acumenis

 

[orbitex]

Hello all, quick thread debunking "erda cannot be ran safely" due to hyperphosphetamia + retinal issues, in this thread i will be debunking this. (i cant do spoilers for some reason so forgive me)

The proposed flaw
" phosphate binders like sevelamer don't actually solve the phosphate problem people think they do. Sevelamer only blocks phosphate absorption in your gut it does nothing about the kidneys reabsorbing phosphate internally, which is the actual thing erdafitinib disrupts. From what I can tell, the only real mitigation oncologists use is dose reduction/interruption based on labs. The retinal and calcification stuff doesn't seem to be something you can supplement your way around, since it's tied directly to the drug's mechanism rather than being a separate side effect."

Why this isnt the same in reality
To induce calcification that their claiming you would need to remain in this state for several months to even years the claim that its done within 7-11 days is fabricated, moreover sevelamer WOULD help and due to how long it hyperphosphetamia needs to be maintained its the reason why low dose + ancillaries + cycling is ideal.

Proposed flaw 2
Eye issues induced by erdafitinib.

Why this isnt the same in reality
20% of users on 8-9mg experienced eye issues which is AGAIN why low dose + ancillaries + cycling is ideal.
Futhermore in studies, 63-65% of cases patients achieve complete resolution of drug-induced retinopathy and for the others they mostly suffered grade 1 symptoms which are very mild .
In another RAGNAR trial, 92% of patients had their visual acuity return completely to baseline

STOP FEARMONGERING ERDAFITINIB
@orbitex @thuuk @guilty

mirin but you can't cycle erda lol

 

[fent]

mirin but you can't cycle erda lol

yea you can lol 3weeks on 1 off, 5 weeks on 2 off

 

[Hexumㅤㅤㅤㅤㅤ]

Hello all, quick thread debunking "erda cannot be ran safely" due to hyperphosphetamia + retinal issues, in this thread i will be debunking this. (i cant do spoilers for some reason so forgive me)

The proposed flaw
" phosphate binders like sevelamer don't actually solve the phosphate problem people think they do. Sevelamer only blocks phosphate absorption in your gut it does nothing about the kidneys reabsorbing phosphate internally, which is the actual thing erdafitinib disrupts. From what I can tell, the only real mitigation oncologists use is dose reduction/interruption based on labs. The retinal and calcification stuff doesn't seem to be something you can supplement your way around, since it's tied directly to the drug's mechanism rather than being a separate side effect."

Why this isnt the same in reality
To induce calcification that their claiming you would need to remain in this state for several months to even years the claim that its done within 7-11 days is fabricated, moreover sevelamer WOULD help and due to how long it hyperphosphetamia needs to be maintained its the reason why low dose + ancillaries + cycling is ideal.

Proposed flaw 2
Eye issues induced by erdafitinib.

Why this isnt the same in reality
20% of users on 8-9mg experienced eye issues which is AGAIN why low dose + ancillaries + cycling is ideal.
Futhermore in studies, 63-65% of cases patients achieve complete resolution of drug-induced retinopathy and for the others they mostly suffered grade 1 symptoms which are very mild .
In another RAGNAR trial, 92% of patients had their visual acuity return completely to baseline

STOP FEARMONGERING ERDAFITINIB
@orbitex @thuuk @guilty

mirin but do you speak good portugese ?

 

[SinisterTRADition]

Mirin babes

 

[SinisterTRADition]

mirin but do you speak good portugese ?

Keep it niche g

 

[orbitex]

yea you can lol 3weeks on 1 off, 5 weeks on 2 off

It takes 9 months to get full results look

 

[Hexumㅤㅤㅤㅤㅤ]

Keep it niche g

sorry bradar will keep it ebk

 

[fent]

mirin but do you speak good portugese ?

saw this on discord

 

[FoidSlayer]

Nice. My plates are closed.

 

[spider]

Nice. My plates are closed.

 

[SinisterTRADition]

Nice. My plates are closed.

I’m 26 but my legs lowk been hurting I think there’s a spurt coming

 

[XvideosDemon]

Hello all, quick thread debunking "erda cannot be ran safely" due to hyperphosphetamia + retinal issues, in this thread i will be debunking this. (i cant do spoilers for some reason so forgive me)

The proposed flaw
" phosphate binders like sevelamer don't actually solve the phosphate problem people think they do. Sevelamer only blocks phosphate absorption in your gut it does nothing about the kidneys reabsorbing phosphate internally, which is the actual thing erdafitinib disrupts. From what I can tell, the only real mitigation oncologists use is dose reduction/interruption based on labs. The retinal and calcification stuff doesn't seem to be something you can supplement your way around, since it's tied directly to the drug's mechanism rather than being a separate side effect."

Why this isnt the same in reality
To induce calcification that their claiming you would need to remain in this state for several months to even years the claim that its done within 7-11 days is fabricated, moreover sevelamer WOULD help and due to how long it hyperphosphetamia needs to be maintained its the reason why low dose + ancillaries + cycling is ideal.

Proposed flaw 2
Eye issues induced by erdafitinib.

Why this isnt the same in reality
20% of users on 8-9mg experienced eye issues which is AGAIN why low dose + ancillaries + cycling is ideal.
Futhermore in studies, 63-65% of cases patients achieve complete resolution of drug-induced retinopathy and for the others they mostly suffered grade 1 symptoms which are very mild .
In another RAGNAR trial, 92% of patients had their visual acuity return completely to baseline

STOP FEARMONGERING ERDAFITINIB
@orbitex @thuuk @guilty

Appreciate the debunk g

Love ya

Also fuck the nigger who impersonated you

I think ik who it was……

 

[Alyx]

Hello all, quick thread debunking "erda cannot be ran safely" due to hyperphosphetamia + retinal issues, in this thread i will be debunking this. (i cant do spoilers for some reason so forgive me)

The proposed flaw
" phosphate binders like sevelamer don't actually solve the phosphate problem people think they do. Sevelamer only blocks phosphate absorption in your gut it does nothing about the kidneys reabsorbing phosphate internally, which is the actual thing erdafitinib disrupts. From what I can tell, the only real mitigation oncologists use is dose reduction/interruption based on labs. The retinal and calcification stuff doesn't seem to be something you can supplement your way around, since it's tied directly to the drug's mechanism rather than being a separate side effect."

Why this isnt the same in reality
To induce calcification that their claiming you would need to remain in this state for several months to even years the claim that its done within 7-11 days is fabricated, moreover sevelamer WOULD help and due to how long it hyperphosphetamia needs to be maintained its the reason why low dose + ancillaries + cycling is ideal.

Proposed flaw 2
Eye issues induced by erdafitinib.

Why this isnt the same in reality
20% of users on 8-9mg experienced eye issues which is AGAIN why low dose + ancillaries + cycling is ideal.
Futhermore in studies, 63-65% of cases patients achieve complete resolution of drug-induced retinopathy and for the others they mostly suffered grade 1 symptoms which are very mild .
In another RAGNAR trial, 92% of patients had their visual acuity return completely to baseline

STOP FEARMONGERING ERDAFITINIB
@orbitex @thuuk @guilty

Very good thread. You're the 2nd best user on this forum.

 

[SinisterTRADition]

Very good thread. You're the 2nd best user on this forum.

And then @SinisterTRADition #1 user walks in

 

[XvideosDemon]

Very good thread. You're the 2nd best user on this forum.

Who’s 1 ?

 

[Alyx]

Who’s 1 ?

@surgerymax

 

[XvideosDemon]

@surgerymax

+ @Daker

Even tho he’s a nigger he is amazing.

 

[goyboy.hero]

Hello all, quick thread debunking "erda cannot be ran safely" due to hyperphosphetamia + retinal issues, in this thread i will be debunking this. (i cant do spoilers for some reason so forgive me)

The proposed flaw
" phosphate binders like sevelamer don't actually solve the phosphate problem people think they do. Sevelamer only blocks phosphate absorption in your gut it does nothing about the kidneys reabsorbing phosphate internally, which is the actual thing erdafitinib disrupts. From what I can tell, the only real mitigation oncologists use is dose reduction/interruption based on labs. The retinal and calcification stuff doesn't seem to be something you can supplement your way around, since it's tied directly to the drug's mechanism rather than being a separate side effect."

Why this isnt the same in reality
To induce calcification that their claiming you would need to remain in this state for several months to even years the claim that its done within 7-11 days is fabricated, moreover sevelamer WOULD help and due to how long it hyperphosphetamia needs to be maintained its the reason why low dose + ancillaries + cycling is ideal.

Proposed flaw 2
Eye issues induced by erdafitinib.

Why this isnt the same in reality
20% of users on 8-9mg experienced eye issues which is AGAIN why low dose + ancillaries + cycling is ideal.
Futhermore in studies, 63-65% of cases patients achieve complete resolution of drug-induced retinopathy and for the others they mostly suffered grade 1 symptoms which are very mild .
In another RAGNAR trial, 92% of patients had their visual acuity return completely to baseline

STOP FEARMONGERING ERDAFITINIB
@orbitex @thuuk @guilty

Mirin, should have linked studies tho

 

[surgerymax]

mogs but id only use pharma grade

 

[fent]

mogs but id only use pharma grade

Very easy to find though lol

 

[fent]

Mirin, should have linked studies tho

You can find everything i said is true with a quick google search + spoilers werent working

 

[goyboy.hero]

You can find everything i said is true with a quick google search + spoilers werent working

Fairs

 

[Acumenis]

@Acumenis

Lol 2 months to poorly cover half the issues on running fgfr3s inhibitors

 

[Judenbänker]

Risks still exist + huge issue imo is skeletal deformities when taking it for a prolonged period

 

[goyboy.hero]

Hello all, quick thread debunking "erda cannot be ran safely" due to hyperphosphetamia + retinal issues, in this thread i will be debunking this. (i cant do spoilers for some reason so forgive me)

The proposed flaw
" phosphate binders like sevelamer don't actually solve the phosphate problem people think they do. Sevelamer only blocks phosphate absorption in your gut it does nothing about the kidneys reabsorbing phosphate internally, which is the actual thing erdafitinib disrupts. From what I can tell, the only real mitigation oncologists use is dose reduction/interruption based on labs. The retinal and calcification stuff doesn't seem to be something you can supplement your way around, since it's tied directly to the drug's mechanism rather than being a separate side effect."

Why this isnt the same in reality
To induce calcification that their claiming you would need to remain in this state for several months to even years the claim that its done within 7-11 days is fabricated, moreover sevelamer WOULD help and due to how long it hyperphosphetamia needs to be maintained its the reason why low dose + ancillaries + cycling is ideal.

Proposed flaw 2
Eye issues induced by erdafitinib.

Why this isnt the same in reality
20% of users on 8-9mg experienced eye issues which is AGAIN why low dose + ancillaries + cycling is ideal.
Futhermore in studies, 63-65% of cases patients achieve complete resolution of drug-induced retinopathy and for the others they mostly suffered grade 1 symptoms which are very mild .
In another RAGNAR trial, 92% of patients had their visual acuity return completely to baseline

STOP FEARMONGERING ERDAFITINIB
@orbitex @thuuk @guilty

Also forgot to include scoliosis and hip problems being debunked

 

[fent]

Lol 2 months to poorly cover half the issues on running fgfr3s inhibitors

list every single one ill do them 1 by 1, i did this in 2 mins because of @orbitex thread about it

 

[fent]

Risks still exist + huge issue imo is skeletal deformities when taking it for a prolonged period

Can be mitigated lol

 

[Judenbänker]

Can be mitigated lol

Did I say it cant?
Still the biggest issue

 

[lewanay]

Hello all, quick thread debunking "erda cannot be ran safely" due to hyperphosphetamia + retinal issues, in this thread i will be debunking this. (i cant do spoilers for some reason so forgive me)

The proposed flaw
" phosphate binders like sevelamer don't actually solve the phosphate problem people think they do. Sevelamer only blocks phosphate absorption in your gut it does nothing about the kidneys reabsorbing phosphate internally, which is the actual thing erdafitinib disrupts. From what I can tell, the only real mitigation oncologists use is dose reduction/interruption based on labs. The retinal and calcification stuff doesn't seem to be something you can supplement your way around, since it's tied directly to the drug's mechanism rather than being a separate side effect."

Why this isnt the same in reality
To induce calcification that their claiming you would need to remain in this state for several months to even years the claim that its done within 7-11 days is fabricated, moreover sevelamer WOULD help and due to how long it hyperphosphetamia needs to be maintained its the reason why low dose + ancillaries + cycling is ideal.

Proposed flaw 2
Eye issues induced by erdafitinib.

Why this isnt the same in reality
20% of users on 8-9mg experienced eye issues which is AGAIN why low dose + ancillaries + cycling is ideal.
Futhermore in studies, 63-65% of cases patients achieve complete resolution of drug-induced retinopathy and for the others they mostly suffered grade 1 symptoms which are very mild .
In another RAGNAR trial, 92% of patients had their visual acuity return completely to baseline

STOP FEARMONGERING ERDAFITINIB
@orbitex @thuuk @guilty

nice