Discussion PDE3 inhibitors - More than a Heart failure medication? (2 Viewers)

[larpwaffen]

PDE3 inhibitors - More than a Heart failure medication?​

Hello everyone, fent in one of my threads said to look into PDE3 inhibitors so i did a dive on them

---

---

---

---

---

Introduction​

At first glance PDE3's seem like a regular vasodilator but after researching, they are one of the most pharmacology interesting vasodilators i've seen.
There is a whole lot to them and I'm suprised how little they are talked about.

---

---

---

---

---

Main Uses/Mechanisms and Types​

A PDE3 inhibitors are medication that stop the action of phosphodiesterase enzyme PDE3.
they are mainly used for heart failure therapy and cardiogenic shock.
it produces a dilation of blood vessels and increase the strength of the hearts muscle contractions and increase heart rate​

Basic mechanism :​

PDE3 breaks down cyclic AMP . Inhibiting it -> higher cAMP -> smooth muscle relaxation + increased cardiac contractions
​

Types: these are the ones approved for human medical use​

cilostazol , milrinone enoximone, pimobendan (only in Japan tho)
this is the boring surface level md shit, onto the good stuff now​

Other benefits and uses:​

​

Anti-depressant​

i came across a study that used PDE3 ihibitors in mice with post stroke / chronic mild stress depression in mice after a stroke.
what they found was very interesting.
After dosing the mice with PDE3 inhibitors the result was "reduction of all depressive behaviours examined"
they concluded that PDE3 may have anti-depressant effects on post-stroke depression through inhibition of neurodegeneration
in the primary lesion and secondary extrafocal sites and promotion of neurogenesis.
These beneficial effects on post-stroke depression may be involved in activation of CREB/BDNF signaling.

​

respiratory disease​

a pubmed study from 2009 found that the muscle relaxment effect of PDE3'smay help
diseases such as asthma
​

Cancer:​

yeah ngl the evidence for this is weak but i might as well add it in.
some studies may suggest that cAMP singnaling influences tumor growth indirectly
PDE ihibition may alter cancer cell signally some how. link is very weak tho

​

---

---

well bhai's im gonna stop here bc i need to study for actual schoolwork. I just wanted to make a quick post bc i thought the finding were very interesting.
also ignore all the typos and i hope the formatting is readable
​

Spoiler: References

main study referenced : https://www.researchgate.net/public..._the_therapeutic_potential_of_PDE3_inhibitors

Wikipedia page of PDE3 inhib : https://en.wikipedia.org/wiki/PDE3_inhibitor
rest:
https://link.springer.com/article/10.1007/s00213-015-4185-6
https://pubmed.ncbi.nlm.nih.gov/19508401/
https://dergipark.org.tr/en/pub/jrespharm/article/1684882

 

[fent]

PDE3 inhibitors - More than a Heart failure medication?​

Hello everyone, fent in one of my threads said to look into PDE3 inhibitors so i did a dive on them

---

---

---

---

---

Introduction​

At first glance PDE3's seem like a regular vasodilator but after researching, they are one of the most pharmacology interesting vasodilators i've seen.
There is a whole lot to them and I'm suprised how little they are talked about.

---

---

---

---

---

Main Uses/Mechanisms and Types​

A PDE3 inhibitors are medication that stop the action of phosphodiesterase enzyme PDE3.
they are mainly used for heart failure therapy and cardiogenic shock.
it produces a dilation of blood vessels and increase the strength of the hearts muscle contractions and increase heart rate​

Basic mechanism :​

PDE3 breaks down cyclic AMP . Inhibiting it -> higher cAMP -> smooth muscle relaxation + increased cardiac contractions
​

Types: these are the ones approved for human medical use​

cilostazol , milrinone enoximone, pimobendan (only in Japan tho)
this is the boring surface level md shit, onto the good stuff now​

Other benefits and uses:​

​

Anti-depressant​

i came across a study that used PDE3 ihibitors in mice with post stroke / chronic mild stress depression in mice after a stroke.
what they found was very interesting.
After dosing the mice with PDE3 inhibitors the result was "reduction of all depressive behaviours examined"
they concluded that PDE3 may have anti-depressant effects on post-stroke depression through inhibition of neurodegeneration
in the primary lesion and secondary extrafocal sites and promotion of neurogenesis.
These beneficial effects on post-stroke depression may be involved in activation of CREB/BDNF signaling.

​

respiratory disease​

a pubmed study from 2009 found that the muscle relaxment effect of PDE3'smay help
diseases such as asthma
​

Cancer:​

yeah ngl the evidence for this is weak but i might as well add it in.
some studies may suggest that cAMP singnaling influences tumor growth indirectly
PDE ihibition may alter cancer cell signally some how. link is very weak tho

​

---

---

well bhai's im gonna stop here bc i need to study for actual schoolwork. I just wanted to make a quick post bc i thought the finding were very interesting.
also ignore all the typos and i hope the formatting is readable
​

Spoiler: References

main study referenced : https://www.researchgate.net/public..._the_therapeutic_potential_of_PDE3_inhibitors

Wikipedia page of PDE3 inhib : https://en.wikipedia.org/wiki/PDE3_inhibitor
rest:
https://link.springer.com/article/10.1007/s00213-015-4185-6
https://pubmed.ncbi.nlm.nih.gov/19508401/
https://dergipark.org.tr/en/pub/jrespharm/article/1684882

Mirin post, im gonna do my own soon for its impact on height

 

[larpwaffen]

Mirin post, im gonna do my own soon for its impact on height

Im ngl i got sidetracked i just realised i didnt link back to LM at all jfl, tag me when u post urs brah

 

[Brian]

PDE3 inhibitors - More than a Heart failure medication?​

Hello everyone, fent in one of my threads said to look into PDE3 inhibitors so i did a dive on them

---

---

---

---

---

Introduction​

At first glance PDE3's seem like a regular vasodilator but after researching, they are one of the most pharmacology interesting vasodilators i've seen.
There is a whole lot to them and I'm suprised how little they are talked about.

---

---

---

---

---

Main Uses/Mechanisms and Types​

A PDE3 inhibitors are medication that stop the action of phosphodiesterase enzyme PDE3.
they are mainly used for heart failure therapy and cardiogenic shock.
it produces a dilation of blood vessels and increase the strength of the hearts muscle contractions and increase heart rate​

Basic mechanism :​

PDE3 breaks down cyclic AMP . Inhibiting it -> higher cAMP -> smooth muscle relaxation + increased cardiac contractions
​

Types: these are the ones approved for human medical use​

cilostazol , milrinone enoximone, pimobendan (only in Japan tho)
this is the boring surface level md shit, onto the good stuff now​

Other benefits and uses:​

​

Anti-depressant​

i came across a study that used PDE3 ihibitors in mice with post stroke / chronic mild stress depression in mice after a stroke.
what they found was very interesting.
After dosing the mice with PDE3 inhibitors the result was "reduction of all depressive behaviours examined"
they concluded that PDE3 may have anti-depressant effects on post-stroke depression through inhibition of neurodegeneration
in the primary lesion and secondary extrafocal sites and promotion of neurogenesis.
These beneficial effects on post-stroke depression may be involved in activation of CREB/BDNF signaling.

​

respiratory disease​

a pubmed study from 2009 found that the muscle relaxment effect of PDE3'smay help
diseases such as asthma
​

Cancer:​

yeah ngl the evidence for this is weak but i might as well add it in.
some studies may suggest that cAMP singnaling influences tumor growth indirectly
PDE ihibition may alter cancer cell signally some how. link is very weak tho

​

---

---

well bhai's im gonna stop here bc i need to study for actual schoolwork. I just wanted to make a quick post bc i thought the finding were very interesting.
also ignore all the typos and i hope the formatting is readable
​

Spoiler: References

main study referenced : https://www.researchgate.net/public..._the_therapeutic_potential_of_PDE3_inhibitors

Wikipedia page of PDE3 inhib : https://en.wikipedia.org/wiki/PDE3_inhibitor
rest:
https://link.springer.com/article/10.1007/s00213-015-4185-6
https://pubmed.ncbi.nlm.nih.gov/19508401/
https://dergipark.org.tr/en/pub/jrespharm/article/1684882

Mirin brah zyzz's coming for you brah zyzz is WATCHING you brah

 

[Brian]

PDE3 inhibitors - More than a Heart failure medication?​

Hello everyone, fent in one of my threads said to look into PDE3 inhibitors so i did a dive on them

---

---

---

---

---

Introduction​

At first glance PDE3's seem like a regular vasodilator but after researching, they are one of the most pharmacology interesting vasodilators i've seen.
There is a whole lot to them and I'm suprised how little they are talked about.

---

---

---

---

---

Main Uses/Mechanisms and Types​

A PDE3 inhibitors are medication that stop the action of phosphodiesterase enzyme PDE3.
they are mainly used for heart failure therapy and cardiogenic shock.
it produces a dilation of blood vessels and increase the strength of the hearts muscle contractions and increase heart rate​

Basic mechanism :​

PDE3 breaks down cyclic AMP . Inhibiting it -> higher cAMP -> smooth muscle relaxation + increased cardiac contractions
​

Types: these are the ones approved for human medical use​

cilostazol , milrinone enoximone, pimobendan (only in Japan tho)
this is the boring surface level md shit, onto the good stuff now​

Other benefits and uses:​

​

Anti-depressant​

i came across a study that used PDE3 ihibitors in mice with post stroke / chronic mild stress depression in mice after a stroke.
what they found was very interesting.
After dosing the mice with PDE3 inhibitors the result was "reduction of all depressive behaviours examined"
they concluded that PDE3 may have anti-depressant effects on post-stroke depression through inhibition of neurodegeneration
in the primary lesion and secondary extrafocal sites and promotion of neurogenesis.
These beneficial effects on post-stroke depression may be involved in activation of CREB/BDNF signaling.

​

respiratory disease​

a pubmed study from 2009 found that the muscle relaxment effect of PDE3'smay help
diseases such as asthma
​

Cancer:​

yeah ngl the evidence for this is weak but i might as well add it in.
some studies may suggest that cAMP singnaling influences tumor growth indirectly
PDE ihibition may alter cancer cell signally some how. link is very weak tho

​

---

---

well bhai's im gonna stop here bc i need to study for actual schoolwork. I just wanted to make a quick post bc i thought the finding were very interesting.
also ignore all the typos and i hope the formatting is readable
​

Spoiler: References

main study referenced : https://www.researchgate.net/public..._the_therapeutic_potential_of_PDE3_inhibitors

Wikipedia page of PDE3 inhib : https://en.wikipedia.org/wiki/PDE3_inhibitor
rest:
https://link.springer.com/article/10.1007/s00213-015-4185-6
https://pubmed.ncbi.nlm.nih.gov/19508401/
https://dergipark.org.tr/en/pub/jrespharm/article/1684882

Good brah

 

[Jail]

PDE3 inhibitors - More than a Heart failure medication?​

Hello everyone, fent in one of my threads said to look into PDE3 inhibitors so i did a dive on them

---

---

---

---

---

Introduction​

At first glance PDE3's seem like a regular vasodilator but after researching, they are one of the most pharmacology interesting vasodilators i've seen.
There is a whole lot to them and I'm suprised how little they are talked about.

---

---

---

---

---

Main Uses/Mechanisms and Types​

A PDE3 inhibitors are medication that stop the action of phosphodiesterase enzyme PDE3.
they are mainly used for heart failure therapy and cardiogenic shock.
it produces a dilation of blood vessels and increase the strength of the hearts muscle contractions and increase heart rate​

Basic mechanism :​

PDE3 breaks down cyclic AMP . Inhibiting it -> higher cAMP -> smooth muscle relaxation + increased cardiac contractions
​

Types: these are the ones approved for human medical use​

cilostazol , milrinone enoximone, pimobendan (only in Japan tho)
this is the boring surface level md shit, onto the good stuff now​

Other benefits and uses:​

​

Anti-depressant​

i came across a study that used PDE3 ihibitors in mice with post stroke / chronic mild stress depression in mice after a stroke.
what they found was very interesting.
After dosing the mice with PDE3 inhibitors the result was "reduction of all depressive behaviours examined"
they concluded that PDE3 may have anti-depressant effects on post-stroke depression through inhibition of neurodegeneration
in the primary lesion and secondary extrafocal sites and promotion of neurogenesis.
These beneficial effects on post-stroke depression may be involved in activation of CREB/BDNF signaling.

​

respiratory disease​

a pubmed study from 2009 found that the muscle relaxment effect of PDE3'smay help
diseases such as asthma
​

Cancer:​

yeah ngl the evidence for this is weak but i might as well add it in.
some studies may suggest that cAMP singnaling influences tumor growth indirectly
PDE ihibition may alter cancer cell signally some how. link is very weak tho

​

---

---

well bhai's im gonna stop here bc i need to study for actual schoolwork. I just wanted to make a quick post bc i thought the finding were very interesting.
also ignore all the typos and i hope the formatting is readable
​

Spoiler: References

main study referenced : https://www.researchgate.net/public..._the_therapeutic_potential_of_PDE3_inhibitors

Wikipedia page of PDE3 inhib : https://en.wikipedia.org/wiki/PDE3_inhibitor
rest:
https://link.springer.com/article/10.1007/s00213-015-4185-6
https://pubmed.ncbi.nlm.nih.gov/19508401/
https://dergipark.org.tr/en/pub/jrespharm/article/1684882

Mirin post

 

[Biomaxx]

PDE3 inhibitors - More than a Heart failure medication?​

Hello everyone, fent in one of my threads said to look into PDE3 inhibitors so i did a dive on them

---

---

---

---

---

Introduction​

At first glance PDE3's seem like a regular vasodilator but after researching, they are one of the most pharmacology interesting vasodilators i've seen.
There is a whole lot to them and I'm suprised how little they are talked about.

---

---

---

---

---

Main Uses/Mechanisms and Types​

A PDE3 inhibitors are medication that stop the action of phosphodiesterase enzyme PDE3.
they are mainly used for heart failure therapy and cardiogenic shock.
it produces a dilation of blood vessels and increase the strength of the hearts muscle contractions and increase heart rate​

Basic mechanism :​

PDE3 breaks down cyclic AMP . Inhibiting it -> higher cAMP -> smooth muscle relaxation + increased cardiac contractions
​

Types: these are the ones approved for human medical use​

cilostazol , milrinone enoximone, pimobendan (only in Japan tho)
this is the boring surface level md shit, onto the good stuff now​

Other benefits and uses:​

​

Anti-depressant​

i came across a study that used PDE3 ihibitors in mice with post stroke / chronic mild stress depression in mice after a stroke.
what they found was very interesting.
After dosing the mice with PDE3 inhibitors the result was "reduction of all depressive behaviours examined"
they concluded that PDE3 may have anti-depressant effects on post-stroke depression through inhibition of neurodegeneration
in the primary lesion and secondary extrafocal sites and promotion of neurogenesis.
These beneficial effects on post-stroke depression may be involved in activation of CREB/BDNF signaling.

​

respiratory disease​

a pubmed study from 2009 found that the muscle relaxment effect of PDE3'smay help
diseases such as asthma
​

Cancer:​

yeah ngl the evidence for this is weak but i might as well add it in.
some studies may suggest that cAMP singnaling influences tumor growth indirectly
PDE ihibition may alter cancer cell signally some how. link is very weak tho

​

---

---

well bhai's im gonna stop here bc i need to study for actual schoolwork. I just wanted to make a quick post bc i thought the finding were very interesting.
also ignore all the typos and i hope the formatting is readable
​

Spoiler: References

main study referenced : https://www.researchgate.net/public..._the_therapeutic_potential_of_PDE3_inhibitors

Wikipedia page of PDE3 inhib : https://en.wikipedia.org/wiki/PDE3_inhibitor
rest:
https://link.springer.com/article/10.1007/s00213-015-4185-6
https://pubmed.ncbi.nlm.nih.gov/19508401/
https://dergipark.org.tr/en/pub/jrespharm/article/1684882

I acc hate you, I was just about to start writing on this

Mirin tho

 

[larpwaffen]

I acc hate you, I was just about to start writing on this

Mirin tho

Sorry bhai

 

[fent]

I acc hate you, I was just about to start writing on this

Mirin tho

no need for my thread then, im excited. @ me

 

[birthdefect]

PDE3 inhibitors - More than a Heart failure medication?​

Hello everyone, fent in one of my threads said to look into PDE3 inhibitors so i did a dive on them

---

---

---

---

---

Introduction​

At first glance PDE3's seem like a regular vasodilator but after researching, they are one of the most pharmacology interesting vasodilators i've seen.
There is a whole lot to them and I'm suprised how little they are talked about.

---

---

---

---

---

Main Uses/Mechanisms and Types​

A PDE3 inhibitors are medication that stop the action of phosphodiesterase enzyme PDE3.
they are mainly used for heart failure therapy and cardiogenic shock.
it produces a dilation of blood vessels and increase the strength of the hearts muscle contractions and increase heart rate​

Basic mechanism :​

PDE3 breaks down cyclic AMP . Inhibiting it -> higher cAMP -> smooth muscle relaxation + increased cardiac contractions
​

Types: these are the ones approved for human medical use​

cilostazol , milrinone enoximone, pimobendan (only in Japan tho)
this is the boring surface level md shit, onto the good stuff now​

Other benefits and uses:​

​

Anti-depressant​

i came across a study that used PDE3 ihibitors in mice with post stroke / chronic mild stress depression in mice after a stroke.
what they found was very interesting.
After dosing the mice with PDE3 inhibitors the result was "reduction of all depressive behaviours examined"
they concluded that PDE3 may have anti-depressant effects on post-stroke depression through inhibition of neurodegeneration
in the primary lesion and secondary extrafocal sites and promotion of neurogenesis.
These beneficial effects on post-stroke depression may be involved in activation of CREB/BDNF signaling.

​

respiratory disease​

a pubmed study from 2009 found that the muscle relaxment effect of PDE3'smay help
diseases such as asthma
​

Cancer:​

yeah ngl the evidence for this is weak but i might as well add it in.
some studies may suggest that cAMP singnaling influences tumor growth indirectly
PDE ihibition may alter cancer cell signally some how. link is very weak tho

​

---

---

well bhai's im gonna stop here bc i need to study for actual schoolwork. I just wanted to make a quick post bc i thought the finding were very interesting.
also ignore all the typos and i hope the formatting is readable
​

Spoiler: References

main study referenced : https://www.researchgate.net/public..._the_therapeutic_potential_of_PDE3_inhibitors

Wikipedia page of PDE3 inhib : https://en.wikipedia.org/wiki/PDE3_inhibitor
rest:
https://link.springer.com/article/10.1007/s00213-015-4185-6
https://pubmed.ncbi.nlm.nih.gov/19508401/
https://dergipark.org.tr/en/pub/jrespharm/article/1684882

nigga i mentioned this to fent literally a day ago and theres already a thread on it
btw i just wanna mention this to any godlike sourcing masters, pde3b is the specific isoform found in bone and fat, pde3a is whats responsible for blood and cardiac effects
if you can find a selective pde3b inhibitor, you would find a pill that makes you leaner and taller with little to no side effects, BUT this is so hard to find it doesnt even have a cas number yet
if you find it please dm me

 

[fent]

nigga i mentioned this to fent literally a day ago and theres already a thread on it
btw i just wanna mention this to any godlike sourcing masters, pde3b is the specific isoform found in bone and fat, pde3a is whats responsible for blood and cardiac effects
if you can find a selective pde3b inhibitor, you would find a pill that makes you leaner and taller with little to no side effects, BUT this is so hard to find it doesnt even have a cas number yet
if you find it please dm me

whats the name of the selective inhibitor ill start looking

 

[birthdefect]

whats the name of the selective inhibitor ill start looking

i dont remember

 

[fent]

i dont remember

cheers

 

[birthdefect]

cheers

im sorry
something mentioned gsk something line of compounds in a study
try searching for that
gsk line pde3b inhibitors
also mentioned boronic acid
i feel like a fortune teller rn

 

[fent]

im sorry
something mentioned gsk something line of compounds in a study
try searching for that
gsk line pde3b inhibitors
also mentioned boronic acid
i feel like a fortune teller rn

giving me 3 pieces of an 1000 piece puzzle

 

[birthdefect]

giving me 3 pieces of an 1000 piece puzzle

nah its enough actually

 

[fent]

nah its enough actually

bro can u atleast give me a name

 

[birthdefect]

bro can u atleast give me a name

i deadass dont remember any names