Serious need dht derivative thats as strong as dht (6 Viewers)

[atrophicpyra]

Osteoblastic cells only respond to mechanotransduction from wnt activation amongst other pathways to self regulate BMD, but it's only a self regulatory mechanism that works for bone healing after fractures or injuries, it wont give you bone projection, so it doesn't work for bone smashing or stuff like that.

bone smashing works through inhibiting sclerostin which promotes bmp pathways but u gotta do it in a technique where u bonesmash 15-30 secs 5-10 x a day

it worked for me for my zygos

wnt activation increases differentiation and proliferation both at the same(differentiation more) time which is why romo is shit it will make u shorter

 

[atrophicpyra]

nah not really, just get the more selective fgfr3 inhibitors, and get abalo.

the more selective ones r so fucking expensive they r made for donald trumps son thats why he is 6'5 at 15

 

[Synapse]

bone smashing works through inhibiting sclerostin which promotes bmp pathways but u gotta do it in a technique where u bonesmash 15-30 secs 5-10 x a day

it worked for me for my zygos

wnt activation increases differentiation and proliferation both at the same time which is why romo is shit it will make u shorter

show the before and after then, at most u got scar tissue.

 

[Synapse]

the more selective ones r so fucking expensive they r made for donald trumps son thats why he is 6'5 at 15

poorcel issues.

 

[atrophicpyra]

yeah, so? receptor binding is irrelevant without ligand availability. the question isn't whether DHT can bind mandibular AR, it is whether DHT is present in sufficient conc. at mandibular osteoblasts to meaningfully participate in receptor occupancy.


View attachment 43610
the periosteum itself lacks the enzymatic activity that converts T to DHT.

and the studies showing DHT increases cortical thickness are predominantly ex vivo or rodent models using supraphysiological concentrations that bear no relationship to human endogenous physiology.

what?

the 5ART2D male in one study had normal T levels, near zero DHT throughout entire life, fully functional androgen receptors.

3/4 patients had completely normal BMD. 4th had osteopenia or whatever, can't remember.

also, the estrogen-bone relationship is mediated via completely different receptors (ER alpha, ER beta) and a different mechanism (anti-resorptive via osteoclast apoptosis). DHT doesn't share this mechanism nigga, why are you comparing them?

View attachment 43611

if DHT was needed for bone density, a suppression like this would cause bone loss. it didn't.

the skeleton requires T and E for maintenance. T acts directly on osteoblasts via AR and indirectly via aromatization to estradiol.

View attachment 43612

shush.



true, but irrelevant.
the real question is: which isoform and at what level?

the Notelovitz review explicitly states that periosteal cells dont have 5AR activity. periosteal apposition is the mechanism by which mandibular widening and angular development takes place. presence of 5AR elsewhere, like trabecular osteoblasts, is irrelevant here.

yk what your actually kind of right mb g, however i still dont wnat to look like a femboy with a 1 inch cock at 15 so if i ever hop on aas im not inhibitng dht only if i see mild hair thinning

 

[atrophicpyra]

show the before and after then, at most u got scar tissue.

no scar tissue and the before and after isnt noticable on camera only irl my friends pointed it out when we went to the gym together 2 weeks ago

 

[Synapse]

bone smashing works through inhibiting sclerostin which promotes bmp pathways but u gotta do it in a technique where u bonesmash 15-30 secs 5-10 x a day

it worked for me for my zygos

wnt activation increases differentiation and proliferation both at the same(differentiation more) time which is why romo is shit it will make u shorter

that technique and theory is a joke same fallacy with roids, u can't grow localized bone the way you want it to, and the mechanism you explained def wont grow ur zygos or any bone whatsoever, using that logic any osteoblast activation will activate the bmp pathway, for example jumping, so does that mean masai jumps work? NO.

It's only a mechanism that works for regulating BMD and reparing bone fractures or injuries, niggas will do anything but fillers and implants cuz "muh migration", 60 dollars HA filler is meanwhile waiting while u are doing brutally stupid mental gymnastics with pseudoscience mechanisms, and also even if you get some bone growth it would be insanely slow and not even 0.5mm lol.

 

[atrophicpyra]

poorcel issues.

$500 budget i could tech buy 2 weeks of tyra 300

 

[Synapse]

yk what your actually kind of right mb g, however i still dont wnat to look like a femboy with a 1 inch cock at 15 so if i ever hop on aas im not inhibitng dht only if i see mild hair thinning

jus use RU or clascolterone.

 

[atrophicpyra]

that technique and theory is a joke same fallacy with roids, u can't grow localized bone the way you want it to, and the mechanism you explained def wont grow ur zygos or any bone whatsoever, using that logic any osteoblast activation will activate the bmp pathway, for example jumping, so does that mean masai jumps work? NO.

It's only a mechanism that works for regulating BMD and reparing bone fractures or injuries, niggas will do anything but fillers and implants cuz "muh migration", 60 dollars HA filler is meanwhile waiting while u are doing brutally stupid mental gymnastics with pseudoscience mechanisms, and also even if you get some bone growth it would be insanely slow and not even 0.5mm lol.

bmps are so powerful at increasing chrondrocyte proliferation osteoblasts wym


not tryna be corny but how else did androgenic, kent, etc. change their face that immensly? there is even proof they roided its not like its bs.

 

[Synapse]

no scar tissue and the before and after isnt noticable on camera only irl my friends pointed it out when we went to the gym together 2 weeks ago

im calling shit that never happened for 200$ alex.

 

[Synapse]

bmps are so powerful at increasing chrondrocyte proliferation osteoblasts wym


not tryna be corny but how else did androgenic, kent, etc. change their face that immensly? there is even proof they roided its not like its bs.

they all abuse fillers lol.

 

[atrophicpyra]

that technique and theory is a joke same fallacy with roids, u can't grow localized bone the way you want it to, and the mechanism you explained def wont grow ur zygos or any bone whatsoever, using that logic any osteoblast activation will activate the bmp pathway, for example jumping, so does that mean masai jumps work? NO.

It's only a mechanism that works for regulating BMD and reparing bone fractures or injuries, niggas will do anything but fillers and implants cuz "muh migration", 60 dollars HA filler is meanwhile waiting while u are doing brutally stupid mental gymnastics with pseudoscience mechanisms, and also even if you get some bone growth it would be insanely slow and not even 0.5mm lol.

also no joke but i was researching massai jumps for a week str8, turns out they do work but they wont lengthen ur bones only make them wider which is useless

 

[atrophicpyra]

they all abuse fillers lol.

proof? how


androgenic got his lab tests read publicly he had 3,410 test levels which is max for a test meaning he is abusing androgens

 

[Synapse]

bmps are so powerful at increasing chrondrocyte proliferation osteoblasts wym


not tryna be corny but how else did androgenic, kent, etc. change their face that immensly? there is even proof they roided its not like its bs.

only for bone repair, also u didnt address the fallacy of the activation pathways, bmps activate for stuff just as simple as walking, if they are constantly getting activated why dont people grow taller from masai jumps and bs like that? lmfao, the only serve as a bmd regulating mechanism, and higher bmd is not the kind of aesthetic bone facial projection u are even looking for lol PrettyBoyMaxxing .

 

[Synapse]

proof? how


androgenic got his lab tests read publicly he had 3,410 test levels which is max for a test meaning he is abusing androgens

If u wanna look like androgenic thats just you ngl .

 

[atrophicpyra]

If u wanna look like androgenic thats just you ngl .

not tryna be corny but i deadass want to

 

[Synapse]

only for bone repair, also u didnt address the fallacy of the activation pathways, bmps activate for stuff just as simple as walking, if they are constantly getting activated why dont people grow taller from masai jumps and bs like that? lmfao, the only serve as a bmd regulating mechanism, and higher bmd is not the kind of aesthetic bone facial projection u are even looking for lol PrettyBoyMaxxing .

not to mention they are already activated all the time because of earth gravity and ur natural movement, all people would have model tier like faces lmfao, it doesn't work like that, higher BMD is not equal to a model tier like face.

 

[atrophicpyra]

only for bone repair, also u didnt address the fallacy of the activation pathways, bmps activate for stuff just as simple as walking, if they are constantly getting activated why dont people grow taller from masai jumps and bs like that? lmfao, the only serve as a bmd regulating mechanism, and higher bmd is not the kind of aesthetic bone facial projection u are even looking for lol PrettyBoyMaxxing .

your right i read the study they walked for 2-3 minutes and they reported 300% more osteoblasts or was it jumping for 2-3 minutes i forgot but ig your right, but that also correlates to how ur femur is the biggest bone of your body

 

[Synapse]

your right i read the study they walked for 2-3 minutes and they reported 300% more osteoblasts or was it jumping for 2-3 minutes i forgot but ig your right, but that also correlates to how ur femur is the biggest bone of your body

just do fillers and save for surgery and implants.

 

[atrophicpyra]

just do fillers and save for surgery and implants.

fillers r deadass $60? thing is i know a friend who died putting fillers in their lips like a few years back kind of traumatize me idk


androgens seem legitthough and there is documented proof from so much creators that use them. androgenic being one of them how else did he get delts the size of his head lol and coincidentally a mogger skull?

 

[Synapse]

fillers r deadass $60? thing is i know a friend who died putting fillers in their lips like a few years back kind of traumatize me idk


androgens seem legitthough and there is documented proof from so much creators that use them. androgenic being one of them how else did he get delts the size of his head lol and coincidentally a mogger skull?

Just dont be a retard and learn how to do fillers properly.

 

[atrophicpyra]

Just dont be a retard and learn how to do fillers properly.

ig gonna check it out, ai is coming in 3-4 weeks wwb is slow gonna update and make a thread 1 month into using

imma go to the gym rn cya boyo