Mogs LOXO-435 (17 Viewers)

[Biomaxx]

could LOXO-435 be the best option for fgfr3 inhibtion ?

Patented by LILLY, LOXO-435 is a highly selective FGFR3 inhibitor

If you are unsure of what fgfr3 does-
https://looksmax.gg/threads/fgfr3-inhibtion-epiphyseal-plates-and-bone-growth.19180/


LOXO-435 is confined to oncologic trials, no pediatric or skeletal growth studies have been initiated.

comparisons
​

Safety. Sides. Efficacy.

​

LOXO	high	very low	high
VORS	high	near to none	mid
ERDA	low	very high	high
INFI	mid	mid	high

Loxo-435

LOXO-435 is the most selective inhibitor studied to date. 361-fold selectivity over FGFR1 and 66-fold over FGFR2 .
This matters because pan-FGFR inhibitors (erdafitinib, infigratinib) hit FGFR1/2/4 and cause body wide toxicities, skin disorders, phosphatemia and more.

Unlike vosoritide and meclozine, which act indirectly via the CNP/cGMP pathway or analogous pathways, LOXO-435, as a direct small molecule inhibitor of the FGFR3 kinase, binds the receptor directly.
(Its direct)

Loxo is oral and taken twice a day (once may be adequate for plates). Around 100mg a day. Theoretically a 2 month onset

Loxo imo, a very promising inhibitor
Highly effective
Highly selective
Direct
Cheap
But long onset

Studies
https://share.google/upuke5VGU4FyoD2bl
https://share.google/skUVinxfXwPurjQmt

https://aacrjournals.org/mct/articl...scovery-of-a-highly-potent-and?sharetype=link


Short thread ik
Yall think ive stepped up my content recently ?

Dexter birthdefect carbon Synapse Mandy tmpll XvideosDemon 9Dino Fram3Let 6ft1Cheat Tismo determinism Hyporoxin brownkeephittin
​

Until next time
biomaxx

 

[nettspend]

Inb4 mirin

 

[XvideosDemon]

could LOXO-435 be the best option for fgfr3 inhibtion ?

Patented by LILLY, LOXO-435 is a highly selective FGFR3 inhibitor

If you are unsure of what fgfr3 does-
https://looksmax.gg/threads/fgfr3-inhibtion-epiphyseal-plates-and-bone-growth.19180/


LOXO-435 is confined to oncologic trials, no pediatric or skeletal growth studies have been initiated.

comparisons
​

Safety. Sides. Efficacy.

​

LOXO	high	very low	high
VORS	high	near to none	mid
ERDA	low	very high	high
INFI	mid	mid	high

View attachment 38569

Loxo-435
View attachment 38568
LOXO-435 is the most selective inhibitor studied to date. 361-fold selectivity over FGFR1 and 66-fold over FGFR2 .
This matters because pan-FGFR inhibitors (erdafitinib, infigratinib) hit FGFR1/2/4 and cause body wide toxicities, skin disorders, phosphatemia and more.

Unlike vosoritide and meclozine, which act indirectly via the CNP/cGMP pathway or analogous pathways, LOXO-435, as a direct small molecule inhibitor of the FGFR3 kinase, binds the receptor directly.
(Its direct)

Loxo is oral and taken twice a day (once may be adequate for plates). Around 100mg a day. Theoretically a 2 month onset

View attachment 38567View attachment 38570

Loxo imo, a very promising inhibitor
Highly effective
Highly selective
Direct
Cheap
But long onset

Studies
https://share.google/upuke5VGU4FyoD2bl
https://share.google/skUVinxfXwPurjQmt

https://aacrjournals.org/mct/articl...scovery-of-a-highly-potent-and?sharetype=link


Short thread ik
Yall think ive stepped up my content recently ?

Dexter birthdefect carbon Synapse Mandy tmpll XvideosDemon 9Dino Fram3Let 6ft1Cheat Tismo determinism Hyporoxin brownkeephittin
​

Until next time
biomaxx

Mirin

 

[Razi]

Nice

 

[nettspend]

Mirin

Yea ok bro

 

[FoidSlayer]

Bad guide, Biomaxx do better bro

 

[Biomaxx]

table got messed up and i cant turn off italics

 

[Hyporoxin]

Nice

 

[Biomaxx]

Godveil Heir why can I edit my shi??

 

[Razi]

Nice

Be original bro you can clearly see that I wrote nice above
These niggas bro

 

[Biomaxx]

Bad guide, Biomaxx do better bro

Istg im going to post your face

 

[FoidSlayer]

Istg im going to post your face

Please don't...

 

[Biomaxx]

Please don't...

Apologise

 

[Razi]

Please don't...

Wait how come I’ve never seen it
Or did it see it ion remember

 

[Biomaxx]

Wait how come I’ve never seen it
Or did it see it ion remember

I found it

 

[Razi]

I found it

What he working with? Ltn?

 

[FoidSlayer]

What he working with? Ltn?

Ltn

 

[FoidSlayer]

Apologise

I'm sorry bio

 

[Razi]

I'm sorry bio

You a bitch

 

[FoidSlayer]

You a bitch

You're Indian

 

[Razi]

You're Indian

no I’m NOT

 

[FoidSlayer]

no I’m NOT

Well don't be mean to me

 

[XvideosDemon]

Yea ok bro

Ig bro

 

[Hyporoxin]

Be original bro you can clearly see that I wrote nice above
These niggas bro

Im blind, but ok I will be original
Biomaxx your thread was exquisite

 

[Razi]

Im blind, but ok I will be original
Biomaxx your thread was exquisite

That’s what’s up I love when you listen to daddy