Mogs LOXO-435 (4 Viewers)

[XvideosDemon]

WhosThat’s what’s up I love when you listen to daddy

 

[Razi]

Dream fr we will look so cute

 

[XvideosDemon]

Dream fr we will look so cute

Sussy

 

[Razi]

Sussy

Go make smoothies nigga

 

[XvideosDemon]

Go make smoothies nigga

We slow rn

 

[Razi]

We slow rn

Where do you work might go there and try in the future

 

[sneakyalex7]

could LOXO-435 be the best option for fgfr3 inhibtion ?

Patented by LILLY, LOXO-435 is a highly selective FGFR3 inhibitor

If you are unsure of what fgfr3 does-
https://looksmax.gg/threads/fgfr3-inhibtion-epiphyseal-plates-and-bone-growth.19180/


LOXO-435 is confined to oncologic trials, no pediatric or skeletal growth studies have been initiated.

comparisons
​

Safety. Sides. Efficacy.

​

LOXO	high	very low	high
VORS	high	near to none	mid
ERDA	low	very high	high
INFI	mid	mid	high

View attachment 38569

Loxo-435
View attachment 38568
LOXO-435 is the most selective inhibitor studied to date. 361-fold selectivity over FGFR1 and 66-fold over FGFR2 .
This matters because pan-FGFR inhibitors (erdafitinib, infigratinib) hit FGFR1/2/4 and cause body wide toxicities, skin disorders, phosphatemia and more.

Unlike vosoritide and meclozine, which act indirectly via the CNP/cGMP pathway or analogous pathways, LOXO-435, as a direct small molecule inhibitor of the FGFR3 kinase, binds the receptor directly.
(Its direct)

Loxo is oral and taken twice a day (once may be adequate for plates). Around 100mg a day. Theoretically a 2 month onset

View attachment 38567View attachment 38570

Loxo imo, a very promising inhibitor
Highly effective
Highly selective
Direct
Cheap
But long onset

Studies
https://share.google/upuke5VGU4FyoD2bl
https://share.google/skUVinxfXwPurjQmt

https://aacrjournals.org/mct/articl...scovery-of-a-highly-potent-and?sharetype=link


Short thread ik
Yall think ive stepped up my content recently ?

Dexter birthdefect carbon Synapse Mandy tmpll XvideosDemon 9Dino Fram3Let 6ft1Cheat Tismo determinism Hyporoxin brownkeephittin
​

Until next time
biomaxx

nice, I recently researched fgfr3 Inhibition and this is very interesting mirin iq

 

[Biomaxx]

could LOXO-435 be the best option for fgfr3 inhibtion ?

Patented by LILLY, LOXO-435 is a highly selective FGFR3 inhibitor

If you are unsure of what fgfr3 does-
https://looksmax.gg/threads/fgfr3-inhibtion-epiphyseal-plates-and-bone-growth.19180/


LOXO-435 is confined to oncologic trials, no pediatric or skeletal growth studies have been initiated.

comparisons
​

Safety. Sides. Efficacy.

​

LOXO	high	very low	high
VORS	high	near to none	mid
ERDA	low	very high	high
INFI	mid	mid	high

View attachment 38569

Loxo-435
View attachment 38568
LOXO-435 is the most selective inhibitor studied to date. 361-fold selectivity over FGFR1 and 66-fold over FGFR2 .
This matters because pan-FGFR inhibitors (erdafitinib, infigratinib) hit FGFR1/2/4 and cause body wide toxicities, skin disorders, phosphatemia and more.

Unlike vosoritide and meclozine, which act indirectly via the CNP/cGMP pathway or analogous pathways, LOXO-435, as a direct small molecule inhibitor of the FGFR3 kinase, binds the receptor directly.
(Its direct)

Loxo is oral and taken twice a day (once may be adequate for plates). Around 100mg a day. Theoretically a 2 month onset

View attachment 38567View attachment 38570

Loxo imo, a very promising inhibitor
Highly effective
Highly selective
Direct
Cheap
But long onset

Studies
https://share.google/upuke5VGU4FyoD2bl
https://share.google/skUVinxfXwPurjQmt

https://aacrjournals.org/mct/articl...scovery-of-a-highly-potent-and?sharetype=link


Short thread ik
Yall think ive stepped up my content recently ?

Dexter birthdefect carbon Synapse Mandy tmpll XvideosDemon 9Dino Fram3Let 6ft1Cheat Tismo determinism Hyporoxin brownkeephittin
​

Until next time
biomaxx

Im boutta buuuuumpppp

 

[Biomaxx]

nice, I recently researched fgfr3 Inhibition and this is very interesting mirin iq

Sorry js realised is replied w jfl, wasnt on purpose

 

[Skulloute]

Good stuff, very good info

 

[Biomaxx]

could LOXO-435 be the best option for fgfr3 inhibtion ?

Patented by LILLY, LOXO-435 is a highly selective FGFR3 inhibitor

If you are unsure of what fgfr3 does-
https://looksmax.gg/threads/fgfr3-inhibtion-epiphyseal-plates-and-bone-growth.19180/


LOXO-435 is confined to oncologic trials, no pediatric or skeletal growth studies have been initiated.

comparisons
​

Safety. Sides. Efficacy.

​

LOXO	high	very low	high
VORS	high	near to none	mid
ERDA	low	very high	high
INFI	mid	mid	high

View attachment 38569

Loxo-435
View attachment 38568
LOXO-435 is the most selective inhibitor studied to date. 361-fold selectivity over FGFR1 and 66-fold over FGFR2 .
This matters because pan-FGFR inhibitors (erdafitinib, infigratinib) hit FGFR1/2/4 and cause body wide toxicities, skin disorders, phosphatemia and more.

Unlike vosoritide and meclozine, which act indirectly via the CNP/cGMP pathway or analogous pathways, LOXO-435, as a direct small molecule inhibitor of the FGFR3 kinase, binds the receptor directly.
(Its direct)

Loxo is oral and taken twice a day (once may be adequate for plates). Around 100mg a day. Theoretically a 2 month onset

View attachment 38567View attachment 38570

Loxo imo, a very promising inhibitor
Highly effective
Highly selective
Direct
Cheap
But long onset

Studies
https://share.google/upuke5VGU4FyoD2bl
https://share.google/skUVinxfXwPurjQmt

https://aacrjournals.org/mct/articl...scovery-of-a-highly-potent-and?sharetype=link


Short thread ik
Yall think ive stepped up my content recently ?

Dexter birthdefect carbon Synapse Mandy tmpll XvideosDemon 9Dino Fram3Let 6ft1Cheat Tismo determinism Hyporoxin brownkeephittin
​

Until next time
biomaxx

Why can't all my threads get there own little section, dior Petition for a p.e.d subforum. Also why cant I edit, also read up, also give me tick back uuuuhhh

 

[realhmtn]

Very interesting

My growth plates are already closed at 5'11,5 , otherwise I'd consider taking it.

Also tag next thread faggot

 

[zentro]

bookmarked, good shit my nigga