Discussion Does nicotine descend you?? (2 Viewers)

[Normielarper]

Title

 

[tmpll]

no bhai smoke 5 packs a day to leanmaxx

 

[Mirin]

Not really, it will make your lungs worse and fuck up your dopamine receptors. Which could ruin good sleep, motivation etc. So indirectly yes. Mark as solution

 

[Dexter]

smoking does rape your growth
i remember talking about it here. if you want i can tell you.

 

[Normielarper]

smoking does rape your growth
i remember talking about it here. if you want i can tell you.

Yes go ahead

 

[Dexter]

Yes go ahead

the entire process of linear growth (via chondrocyte proliferation, chondrocyte hypertrophy, matrix mineralization, osteoblastic replacement) gets interfered by smoking.

nicotine suppresses the GH-IGF1 axis.
in normal physiology, this would be the case:
hypo -> ghrh
pituitary -> pulsatile gh secretion
liver -> igf1
igf1 -> chondrocyte div in growth plates

what nicotine does:
activates alpha4beta2 nictinic acetylcholine receptor at CNS
increase dopamine and cortisol
blunts nocturnal gh pulses
reduces hepatic igf1 synthesis

Nicotine also causes chronic hypoxia at growth plate level
bcz growth plates are avascular so they rely ENTIRELY on O2 and nutrients diffusion from surrounding capillaries

what smoking introduces:
CO (carbon monoxide) -> binds Hb with 200x (iirc) affinity of O2
nicotine -> vasoconstriction (bcz of sympathetic activation)
endothelial dysfunction -> less nitric oxide available

THAT OVERALL creates functional hypoxia in the growth plates

hypoxia inhibits chondrocytic hypertrophy, accelerates premature closure of plates, activates hypoxia inducible stress pathways instead of growth pathways like in normal niggas

also cortisol is raised
cortisol inhibits collagen type II synthesis

there's a toxicity to griwth plate chondrocytes as well because tobacco smoke contains:
polycyclic aromatic hydrocarbons
cadmium
reactive oxygen species

they induce oxidative DNA damage in chondrocytes, increase apoptosis, reduce extracellular matrix production, activate inflammatory NF-kB signalling (couldn't find the symbol)

then nicotine also alters DNA methylation patterns, histone acetylation, microRNA expression related to growth and they reduce responsiveness to gh and igf1

 

[tmpll]

the entire process of linear growth (via chondrocyte proliferation, chondrocyte hypertrophy, matrix mineralization, osteoblastic replacement) gets interfered by smoking.

nicotine suppresses the GH-IGF1 axis.
in normal physiology, this would be the case:
hypo -> ghrh
pituitary -> pulsatile gh secretion
liver -> igf1
igf1 -> chondrocyte div in growth plates

what nicotine does:
activates alpha4beta2 nictinic acetylcholine receptor at CNS
increase dopamine and cortisol
blunts nocturnal gh pulses
reduces hepatic igf1 synthesis

Nicotine also causes chronic hypoxia at growth plate level
bcz growth plates are avascular so they rely ENTIRELY on O2 and nutrients diffusion from surrounding capillaries

what smoking introduces:
CO (carbon monoxide) -> binds Hb with 200x (iirc) affinity of O2
nicotine -> vasoconstriction (bcz of sympathetic activation)
endothelial dysfunction -> less nitric oxide available

THAT OVERALL creates functional hypoxia in the growth plates

hypoxia inhibits chondrocytic hypertrophy, accelerates premature closure of plates, activates hypoxia inducible stress pathways instead of growth pathways like in normal niggas

also cortisol is raised
cortisol inhibits collagen type II synthesis

there's a toxicity to griwth plate chondrocytes as well because tobacco smoke contains:
polycyclic aromatic hydrocarbons
cadmium
reactive oxygen species

they induce oxidative DNA damage in chondrocytes, increase apoptosis, reduce extracellular matrix production, activate inflammatory NF-kB signalling (couldn't find the symbol)

then nicotine also alters DNA methylation patterns, histone acetylation, microRNA expression related to growth and they reduce responsiveness to gh and igf1

high iq

 

[Normielarper]

the entire process of linear growth (via chondrocyte proliferation, chondrocyte hypertrophy, matrix mineralization, osteoblastic replacement) gets interfered by smoking.

nicotine suppresses the GH-IGF1 axis.
in normal physiology, this would be the case:
hypo -> ghrh
pituitary -> pulsatile gh secretion
liver -> igf1
igf1 -> chondrocyte div in growth plates

what nicotine does:
activates alpha4beta2 nictinic acetylcholine receptor at CNS
increase dopamine and cortisol
blunts nocturnal gh pulses
reduces hepatic igf1 synthesis

Nicotine also causes chronic hypoxia at growth plate level
bcz growth plates are avascular so they rely ENTIRELY on O2 and nutrients diffusion from surrounding capillaries

what smoking introduces:
CO (carbon monoxide) -> binds Hb with 200x (iirc) affinity of O2
nicotine -> vasoconstriction (bcz of sympathetic activation)
endothelial dysfunction -> less nitric oxide available

THAT OVERALL creates functional hypoxia in the growth plates

hypoxia inhibits chondrocytic hypertrophy, accelerates premature closure of plates, activates hypoxia inducible stress pathways instead of growth pathways like in normal niggas

also cortisol is raised
cortisol inhibits collagen type II synthesis

there's a toxicity to griwth plate chondrocytes as well because tobacco smoke contains:
polycyclic aromatic hydrocarbons
cadmium
reactive oxygen species

they induce oxidative DNA damage in chondrocytes, increase apoptosis, reduce extracellular matrix production, activate inflammatory NF-kB signalling (couldn't find the symbol)

then nicotine also alters DNA methylation patterns, histone acetylation, microRNA expression related to growth and they reduce responsiveness to gh and igf1

what’s your iq Holy fuck

 

[Dexter]

what’s your iq Holy fuck

65

 

[Normielarper]

65

 

[mysticx]

Title

no it ascends u. better focus and suppresses appetite

 

[Mirin]

the entire process of linear growth (via chondrocyte proliferation, chondrocyte hypertrophy, matrix mineralization, osteoblastic replacement) gets interfered by smoking.

nicotine suppresses the GH-IGF1 axis.
in normal physiology, this would be the case:
hypo -> ghrh
pituitary -> pulsatile gh secretion
liver -> igf1
igf1 -> chondrocyte div in growth plates

what nicotine does:
activates alpha4beta2 nictinic acetylcholine receptor at CNS
increase dopamine and cortisol
blunts nocturnal gh pulses
reduces hepatic igf1 synthesis

Nicotine also causes chronic hypoxia at growth plate level
bcz growth plates are avascular so they rely ENTIRELY on O2 and nutrients diffusion from surrounding capillaries

what smoking introduces:
CO (carbon monoxide) -> binds Hb with 200x (iirc) affinity of O2
nicotine -> vasoconstriction (bcz of sympathetic activation)
endothelial dysfunction -> less nitric oxide available

THAT OVERALL creates functional hypoxia in the growth plates

hypoxia inhibits chondrocytic hypertrophy, accelerates premature closure of plates, activates hypoxia inducible stress pathways instead of growth pathways like in normal niggas

also cortisol is raised
cortisol inhibits collagen type II synthesis

there's a toxicity to griwth plate chondrocytes as well because tobacco smoke contains:
polycyclic aromatic hydrocarbons
cadmium
reactive oxygen species

they induce oxidative DNA damage in chondrocytes, increase apoptosis, reduce extracellular matrix production, activate inflammatory NF-kB signalling (couldn't find the symbol)

then nicotine also alters DNA methylation patterns, histone acetylation, microRNA expression related to growth and they reduce responsiveness to gh and igf1

• Stunted Height: Studies indicate that teenage boys who smoke can be, on average, 2.54 centimeters (1 inch) shorter than non-smokers.

 

[Normielarper]

no it ascends u. better focus and suppresses appetite

The doctor said it makes your growth fucked so I don’t believe you

 

[dookiebootybutt59]

yes , take ketamine instead

 

[carbon]

the entire process of linear growth (via chondrocyte proliferation, chondrocyte hypertrophy, matrix mineralization, osteoblastic replacement) gets interfered by smoking.

nicotine suppresses the GH-IGF1 axis.
in normal physiology, this would be the case:
hypo -> ghrh
pituitary -> pulsatile gh secretion
liver -> igf1
igf1 -> chondrocyte div in growth plates

what nicotine does:
activates alpha4beta2 nictinic acetylcholine receptor at CNS
increase dopamine and cortisol
blunts nocturnal gh pulses
reduces hepatic igf1 synthesis

Nicotine also causes chronic hypoxia at growth plate level
bcz growth plates are avascular so they rely ENTIRELY on O2 and nutrients diffusion from surrounding capillaries

what smoking introduces:
CO (carbon monoxide) -> binds Hb with 200x (iirc) affinity of O2
nicotine -> vasoconstriction (bcz of sympathetic activation)
endothelial dysfunction -> less nitric oxide available

THAT OVERALL creates functional hypoxia in the growth plates

hypoxia inhibits chondrocytic hypertrophy, accelerates premature closure of plates, activates hypoxia inducible stress pathways instead of growth pathways like in normal niggas

also cortisol is raised
cortisol inhibits collagen type II synthesis

there's a toxicity to griwth plate chondrocytes as well because tobacco smoke contains:
polycyclic aromatic hydrocarbons
cadmium
reactive oxygen species

they induce oxidative DNA damage in chondrocytes, increase apoptosis, reduce extracellular matrix production, activate inflammatory NF-kB signalling (couldn't find the symbol)

then nicotine also alters DNA methylation patterns, histone acetylation, microRNA expression related to growth and they reduce responsiveness to gh and igf1

Exactly what I would’ve said

 

[Mirin]

Exactly what I would’ve said

Larp lol

 

[sensitive sapphire]

smoking does rape your growth
i remember talking about it here. if you want i can tell you.

some niggas say it can hypothetically incres gh but makes the vitamin absorptions worse

 

[dookiebootybutt59]

some niggas say it can hypothetically incres gh but makes the vitamin absorptions worse

you used the term hypothetically wrong, say theoretically instead

 

[sensitive sapphire]

you used the term hypothetically wrong, say theoretically instead

mb

 

[dookiebootybutt59]

mb

i'll let it slide this time, dont slip up again.

 

[LifeEnjoyer]

Title

clavicular left some disturbies in the people

 

[Normielarper]

clavicular left some disturbies in the people

 

[LifeEnjoyer]

the entire process of linear growth (via chondrocyte proliferation, chondrocyte hypertrophy, matrix mineralization, osteoblastic replacement) gets interfered by smoking.

nicotine suppresses the GH-IGF1 axis.
in normal physiology, this would be the case:
hypo -> ghrh
pituitary -> pulsatile gh secretion
liver -> igf1
igf1 -> chondrocyte div in growth plates

what nicotine does:
activates alpha4beta2 nictinic acetylcholine receptor at CNS
increase dopamine and cortisol
blunts nocturnal gh pulses
reduces hepatic igf1 synthesis

Nicotine also causes chronic hypoxia at growth plate level
bcz growth plates are avascular so they rely ENTIRELY on O2 and nutrients diffusion from surrounding capillaries

what smoking introduces:
CO (carbon monoxide) -> binds Hb with 200x (iirc) affinity of O2
nicotine -> vasoconstriction (bcz of sympathetic activation)
endothelial dysfunction -> less nitric oxide available

THAT OVERALL creates functional hypoxia in the growth plates

hypoxia inhibits chondrocytic hypertrophy, accelerates premature closure of plates, activates hypoxia inducible stress pathways instead of growth pathways like in normal niggas

also cortisol is raised
cortisol inhibits collagen type II synthesis

there's a toxicity to griwth plate chondrocytes as well because tobacco smoke contains:
polycyclic aromatic hydrocarbons
cadmium
reactive oxygen species

they induce oxidative DNA damage in chondrocytes, increase apoptosis, reduce extracellular matrix production, activate inflammatory NF-kB signalling (couldn't find the symbol)

then nicotine also alters DNA methylation patterns, histone acetylation, microRNA expression related to growth and they reduce responsiveness to gh and igf1

high iq

 

[LifeEnjoyer]

i'll let it slide this time, dont slip up again.

. you're so humble

 

[sensitive sapphire]

i'll let it slide this time, dont slip up again.

i knew i wasnt completely wrong nigger