Discussion Does nicotine descend you?? (1 Viewer)

[Dexter]

some niggas say it can hypothetically incres gh but makes the vitamin absorptions worse

yes nicotine acutely stimulates GH release. 1 cigar or nic administration can cause spike in serum GH within like 20 mins or something

nicotine binds to nicotinic acetylcholine receptors on hypothalamic neurons triggering ghrh release and inhibiting somatostatin, this causes a brief increase of gh from the pituitary

70% of gh secretion occurs during deep sleep but nicotine disrupts sleep and directly blunts the amplitude of these nocturnal pulses

components of cigarette smoke like polycyclic aromatic hydrocarbons induce the enzymes CYP1A1 and CYP1B1 in the liver and kidney and these enzymes accelerate the catabolism of 25 hydroxyvitamin d and 1,25 dihydroxyvitamin d into inactive metabolites

lower vitamin d = less calcium absorbed from the gut
nicotine increases urinary calcium loss
smoking creates an acidic metabolic state. the body will literally leach calcium from bone to buffer the blood ph

cyanide from smoke is metabolized into thiocyanate which can interfere with B12 metabolism and the oxidative stress depletes folate. these are methyl donors and their depletion directly impairs the DNA methylation patterns

 

[dookiebootybutt59]

i knew i wasnt completely wrong nigger

you still spelt "increase" incorrectly in your original post jfl

 

[sensitive sapphire]

you still spelt "increase" incorrectly in your original post jfl

i know jfl i suck at spelling

 

[zach63]

the entire process of linear growth (via chondrocyte proliferation, chondrocyte hypertrophy, matrix mineralization, osteoblastic replacement) gets interfered by smoking.

nicotine suppresses the GH-IGF1 axis.
in normal physiology, this would be the case:
hypo -> ghrh
pituitary -> pulsatile gh secretion
liver -> igf1
igf1 -> chondrocyte div in growth plates

what nicotine does:
activates alpha4beta2 nictinic acetylcholine receptor at CNS
increase dopamine and cortisol
blunts nocturnal gh pulses
reduces hepatic igf1 synthesis

Nicotine also causes chronic hypoxia at growth plate level
bcz growth plates are avascular so they rely ENTIRELY on O2 and nutrients diffusion from surrounding capillaries

what smoking introduces:
CO (carbon monoxide) -> binds Hb with 200x (iirc) affinity of O2
nicotine -> vasoconstriction (bcz of sympathetic activation)
endothelial dysfunction -> less nitric oxide available

THAT OVERALL creates functional hypoxia in the growth plates

hypoxia inhibits chondrocytic hypertrophy, accelerates premature closure of plates, activates hypoxia inducible stress pathways instead of growth pathways like in normal niggas

also cortisol is raised
cortisol inhibits collagen type II synthesis

there's a toxicity to griwth plate chondrocytes as well because tobacco smoke contains:
polycyclic aromatic hydrocarbons
cadmium
reactive oxygen species

they induce oxidative DNA damage in chondrocytes, increase apoptosis, reduce extracellular matrix production, activate inflammatory NF-kB signalling (couldn't find the symbol)

then nicotine also alters DNA methylation patterns, histone acetylation, microRNA expression related to growth and they reduce responsiveness to gh and igf1

what about niggatine?

 

[Dexter]

what about niggatine?

causes multiple orgasms in your anal muscles

 

[XvideosDemon]

Title

Nah bro js snort coke do meth and smoke sum Marborel reds and you’ll be looking like Sean o pry

 

[ogre]

the entire process of linear growth (via chondrocyte proliferation, chondrocyte hypertrophy, matrix mineralization, osteoblastic replacement) gets interfered by smoking.

nicotine suppresses the GH-IGF1 axis.
in normal physiology, this would be the case:
hypo -> ghrh
pituitary -> pulsatile gh secretion
liver -> igf1
igf1 -> chondrocyte div in growth plates

what nicotine does:
activates alpha4beta2 nictinic acetylcholine receptor at CNS
increase dopamine and cortisol
blunts nocturnal gh pulses
reduces hepatic igf1 synthesis

Nicotine also causes chronic hypoxia at growth plate level
bcz growth plates are avascular so they rely ENTIRELY on O2 and nutrients diffusion from surrounding capillaries

what smoking introduces:
CO (carbon monoxide) -> binds Hb with 200x (iirc) affinity of O2
nicotine -> vasoconstriction (bcz of sympathetic activation)
endothelial dysfunction -> less nitric oxide available

THAT OVERALL creates functional hypoxia in the growth plates

hypoxia inhibits chondrocytic hypertrophy, accelerates premature closure of plates, activates hypoxia inducible stress pathways instead of growth pathways like in normal niggas

also cortisol is raised
cortisol inhibits collagen type II synthesis

there's a toxicity to griwth plate chondrocytes as well because tobacco smoke contains:
polycyclic aromatic hydrocarbons
cadmium
reactive oxygen species

they induce oxidative DNA damage in chondrocytes, increase apoptosis, reduce extracellular matrix production, activate inflammatory NF-kB signalling (couldn't find the symbol)

then nicotine also alters DNA methylation patterns, histone acetylation, microRNA expression related to growth and they reduce responsiveness to gh and igf1

So basically I was looksmaxing at 6 by smoking and making myself not 6'9 like my brother

 

[Z1gler7]

Title

maybe appetite suppressant but not good long term

 

[sensitive sapphire]

So basically I was looksmaxing at 6 by smoking and making myself not 6'9 like my brother

niggas be 6'5 and still biter about not being taller

 

[mysticx]

The doctor said it makes your growth fucked so I don’t believe you

probably if ur doing high doses daily