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Discussion Biomaxx AMA (10 Viewers)

Discussion Biomaxx AMA

Circadex

The real "child of renaissance"
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Its always fucking you man 😭😭
Answer buddy. Unforseen consequences of unimaginable size await you, if you decide to not answer the question
 

Synapzyzz

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The Grove
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Fram3Let

pls tren i need this
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are you, dexter and i the only ones with a contributor badge?
give bio's contributor back Synapzyzz Synapzyzz
Biomaxx Biomaxx
 

Biomaxx

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How does isotretinoin reduce sebum production, normalize keratinization, decrease Cutibacterium acnes colonization, and exert anti-inflammatory effects at the molecular and cellular levels? In your answer, include:

The active intracellular targets and transcriptional changes (nuclear receptors, signaling pathways) responsible for decreased sebocyte lipogenesis and proliferation.

How isotretinoin alters keratinocyte differentiation and follicular epithelial desquamation at the molecular level.

Mechanisms by which isotretinoin reduces C. acnes load indirectly (not antibiotic activity), including effects on follicular environment and innate immunity.

Specific anti‑inflammatory actions: cytokines, immune cell phenotypes, and pathways modulated.

How isotretinoin’s stereochemistry and metabolism (isomerization to tretinoin/4‑oxo metabolites) relate to its mechanism of action and systemic side effects (e.g., hypertriglyceridemia, mucocutaneous dryness).
Ummm soemthing something fox pathway, oil reduction causing dryness and pore shrinkage
 

Circadex

The real "child of renaissance"
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How much are you holding yourself from making out with me 1 -10?
aemond-targaryen-aemond-1.gif
 

Mandy

It’s just Mandy,baby💋
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Accelerates ossification as far as I know, if youre plates are hypertrophied, romo is a large no go
No,dosen’t act on internal chondrocytes such as the resting,hypertrophic or proliferation zone. Now I’m not saying I’m 100% right,but since it’s sclerostin inhibiting it acts on the ossification zone where calcified chondrocytes are transitioned into osteocytes which dosen’t generally affect total cartilage maturation It may have a affect, but I reckon it’s not as you know.
 

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