Mechanical load is not cope, and is crucial for bone development. Ur bones need to experience load to actually send the signaling cascade of mechanotransduction. Mechanical load sends an input signal that activates integrins, which activates the caveolin to recruit igf-1 receptors. With the presence of igf-1, igf-1 connects to the receptors and sparks the circuit that leads to the nucleus where genetic transcription is made for expression.
Take this into account: you have the lowest expression possible for your genes, and the highest expression possible of your genes, meaning while you can’t change ur genetics, you directly influence how expressive ur genes are, basically how attractive ur genetics for bones can be, and mechanical load to induce these pathway’s reactions are crucial for max genetic expression. (Rq the whole point of genetic expression is to show how enduring ur genetics are to environments, showing ur genetics have a high survival rate with a need to be passed on biologically, which is why small bones people we see as bitches and big boned people we see as more superior).
Mechanical load also generates localized igf-1 to be released in the bone tissue, as well as with systemic igf-1, mechanical load activated proteases that cleave igfbps from the systemic igf-1 so they can actually connect to the igf-1 receptors.
(Proof I wrote this on miro so that retards don’t think I’m stealing other peoples shit)
Take this into account: you have the lowest expression possible for your genes, and the highest expression possible of your genes, meaning while you can’t change ur genetics, you directly influence how expressive ur genes are, basically how attractive ur genetics for bones can be, and mechanical load to induce these pathway’s reactions are crucial for max genetic expression. (Rq the whole point of genetic expression is to show how enduring ur genetics are to environments, showing ur genetics have a high survival rate with a need to be passed on biologically, which is why small bones people we see as bitches and big boned people we see as more superior).
Mechanical load also generates localized igf-1 to be released in the bone tissue, as well as with systemic igf-1, mechanical load activated proteases that cleave igfbps from the systemic igf-1 so they can actually connect to the igf-1 receptors.
(Proof I wrote this on miro so that retards don’t think I’m stealing other peoples shit)
