Mandy
It’s just Mandy,baby💋
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Imagine you starve your osteoblasts from glucose,the preferred energy source that dosen’t shift to fat oxidation except necessary. You have sluggish osteoblasts due to the fact you have inactive WNT-10B and GLUT 1&4.
WNT3A,WNT10B,is stimulated by glycolysis,meanwhile GLUT4,1 and 3 remain sluggish if you starve your osteoblasts from glucose and insulin stimulation. On glycolysis you have a far superior ATP/AMPK ratio,which is crucial for deciding cell,especially osteoblast activity. Glucose stimulated both glycolysis and ß-catenin,which guess what? Stimulates the second form of MTORC2,reducing apoptosis risk.
As it says,osteoblasts always demand glucose,it’s not like other specific tissue like muscle where depending on demand (physical strain for example) where it switches from fat oxidation to glucose.
WNT10B and WNT3A are confirmed pathways to stimulate bone formation.
This is why you see all these primal and carnivore copers they lack proper craniofacial development but can have things like height and health indicators due to just nutrients,but lack TSP and Dimo.
They can only improve health indicators but never get past having more dimo than Björn Andresen.
WNT3A,WNT10B,is stimulated by glycolysis,meanwhile GLUT4,1 and 3 remain sluggish if you starve your osteoblasts from glucose and insulin stimulation. On glycolysis you have a far superior ATP/AMPK ratio,which is crucial for deciding cell,especially osteoblast activity. Glucose stimulated both glycolysis and ß-catenin,which guess what? Stimulates the second form of MTORC2,reducing apoptosis risk.
As it says,osteoblasts always demand glucose,it’s not like other specific tissue like muscle where depending on demand (physical strain for example) where it switches from fat oxidation to glucose.
WNT10B and WNT3A are confirmed pathways to stimulate bone formation.
This is why you see all these primal and carnivore copers they lack proper craniofacial development but can have things like height and health indicators due to just nutrients,but lack TSP and Dimo.
They can only improve health indicators but never get past having more dimo than Björn Andresen.

