I saw
Mandy made a beautiful thread on why GHK-CU is cope and wanted to add more on to this
.Caution:
(Due to lack of research and literature regarding this peptide, there will be part's where I attack claims from a theoretical and mechanism POV)
Preview:
I see a lot of people falling for the this peptide via social media thinking it will give them better glowing skin which is just not the case, influencer's are making a lot of money selling this via linking you to there over priced peptide store and telling you to wait 3 months for results so you keep buying it without seeing any improvement at all thus falling for the marketing scam trap.(Due to lack of research and literature regarding this peptide, there will be part's where I attack claims from a theoretical and mechanism POV)
Preview:
Here are some common videos you will see regarding this Fuck ass peptide, take a second to Cage at there competence
:Claim number 1: "You need to take zinc with GHK-CU to negate copper toxicity"
Lets use some math here since I dont even think most people understand how a chemical copper attachment converts to mg in a human.
Source: PubChem (CID: 161323)
GHK-CU is a 1:1 complex:
1 molecule GHK = 340g/mol
1 copper ion (Cu+2) = 63.5g/mol
For a total 403g/mol
So copper makes up 15.7% of the weight here:
Now lets say your doing a daily injection of 2mg for example:
2 mg × 0.157 = 0.314 mg copper
0.314 mg × 1000 = 314 micrograms
Source regarding copper intake in humans:
https://ods.od.nih.gov/factsheets/Copper-HealthProfessional/
Based on the Tolerable Upper intake Level the (UL)
10mg a day in adults is the tolerable limit, (Which is no where near what GHK contains LMFAO) which is far below UL
0.314mg of copper < 10mg(which is tolerable btw)
Let me even be generous and nice here and say your taking 5mg of GHK-Cu, that still fucking below the UL limit.
0.785mg is still > 10mg
So claims like:
"You need to add Zinc to balance out the copper bruh"
Are fucking comical to me n shows me you have 0 understanding of chemistry, unit conversion and pharmacology.
On top of the Zinc deficiency is rare in healthy adults in developed countries especially if your not vegan
Even in the off chance you where to even receive "copper overload" your bodies homeostasis does a very good job at regulating copper tightly. So even the smallest bump increase is extremely unlikely to cause a imbalance in your average healthy adult, so again no need for "aDd zInC bRo"
Claim Number 2: "Muh More collagen bro"
A common study you will see referenced from GHK-CU being a mega collagen booster is this study:
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/
Lets take sometime to analyze this study here shall we:
First off, this isn't even a study, rather its a review of a study
Second off, note the people who are conducting/reviewing the study:
First this Paper was done by Loren Pickart, who is strongly associated with GHK-CU commercialization thefore making claim bias > net neutral style paper.
But when we look further we realize he also sells it on top of that:
(Conflict of interest ?)
It jus so happens He's the owner of this place as well, more focused on selling overpriced goyslop product that cant even fix his own Norwood 7 JFL AKA the GHK-CU some of y'all love to rave about:
But let me not attack the person, rather I will disect some of the information on this paper:
What makes it more comically obvious is the fact there trying to compare there collagen benifits to weaker products such as vitamin C and regular retinoid acid. NOTICE THEY DID NOT COMPARE Taz, Trent, Red Light, Micro needle, and so on. Cause he knew it would make the collagen benifits not look as good when compared to real products that actually fucking work JFL.
So I will never understand why people use this as a justification to even go out of there way to make DIY serums of GHK-CU and some even using this paper as n excuse to inject it LMFAO.
Now for injectable, since there is lack of research regarding this we will speak from a theoretical mechanism POV:
Now there is some theoretical rumors regarding PBS vs BAC Water, but since other have made threads on this I will assume PBS is being used here and give it the benefit of the doubt.
Copper is required for Lysl oxidase -> collagen cross linking showed below, but here is the part most people miss, that enzyme is already functionally normal in healthy adults. Unless your copper deficient (Super fucking unlikely) , Adding more copper doesn't linearly increase Lyme activity since there already saturated due to the body's homeostatic buffering.
Source: https://www.sciencedirect.com/science/article/abs/pii/0955286396000769?utm_
Its equivalent to saying oxygen is vital for muscle growth, but that does not mean breathing in more oxygen = more muscle
People love to reference this part of the study as a reason to use injectable for "muh more collagen". The problem with this is when there is a wound environment (destroyed ECM collagen break down) But to simply this:
Wound = less collagen in area, so injecting it (PBS) restores collagen in area back to fucking normal!!!!!, so in reality, your average skin is not even in repair state to even benefit from this shit, 0 enhancements above healthy levels.
This doesnt even take into account that Rodents heal much FASTER than humans
Dont believe me ?:
Source: https://www.researchgate.net/figure...d-rodent-skin-a-An-acute-wound_fig1_354711463
TD;LR:
In copper sufficient healthy adults (Majority of adults), collagen production is not limited by copper availability, so systemic GHK-Cu is unlikely to produce meaningful aesthetic improvements beyond wound healing. Its placebo if anyone reports skin glowing claims n scams you
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/
Lets take sometime to analyze this study here shall we
:First off, this isn't even a study, rather its a review of a study
Second off, note the people who are conducting/reviewing the study:
First this Paper was done by Loren Pickart, who is strongly associated with GHK-CU commercialization thefore making claim bias > net neutral style paper.
But when we look further we realize he also sells it on top of that
:(Conflict of interest ?)
It jus so happens He's the owner of this place as well, more focused on selling overpriced goyslop product that cant even fix his own Norwood 7 JFL
AKA the GHK-CU some of y'all love to rave about:But let me not attack the person, rather I will disect some of the information on this paper
:What makes it more comically obvious is the fact there trying to compare there collagen benifits to weaker products such as vitamin C and regular retinoid acid. NOTICE THEY DID NOT COMPARE Taz, Trent, Red Light, Micro needle, and so on. Cause he knew it would make the collagen benifits not look as good when compared to real products that actually fucking work JFL.
So I will never understand why people use this as a justification to even go out of there way to make DIY serums of GHK-CU and some even using this paper as n excuse to inject it LMFAO.
Now for injectable, since there is lack of research regarding this we will speak from a theoretical mechanism POV:
Now there is some theoretical rumors regarding PBS vs BAC Water, but since other have made threads on this I will assume PBS is being used here and give it the benefit of the doubt.
Copper is required for Lysl oxidase -> collagen cross linking showed below, but here is the part most people miss, that enzyme is already functionally normal in healthy adults. Unless your copper deficient (Super fucking unlikely) , Adding more copper doesn't linearly increase Lyme activity since there already saturated due to the body's homeostatic buffering.
Source: https://www.sciencedirect.com/science/article/abs/pii/0955286396000769?utm_
Its equivalent to saying oxygen is vital for muscle growth, but that does not mean breathing in more oxygen = more muscle
People love to reference this part of the study as a reason to use injectable for "muh more collagen". The problem with this is when there is a wound environment (destroyed ECM collagen break down) But to simply this:
Wound = less collagen in area, so injecting it (PBS) restores collagen in area back to fucking normal!!!!!, so in reality, your average skin is not even in repair state to even benefit from this shit, 0 enhancements above healthy levels.
This doesnt even take into account that Rodents heal much FASTER than humans
Dont believe me ?:
Source: https://www.researchgate.net/figure...d-rodent-skin-a-An-acute-wound_fig1_354711463
TD;LR:
In copper sufficient healthy adults (Majority of adults), collagen production is not limited by copper availability, so systemic GHK-Cu is unlikely to produce meaningful aesthetic improvements beyond wound healing. Its placebo if anyone reports skin glowing claims n scams you
Claim number 3: "Hair benifits"
The Hair benifits of this collagen peptide are massively overrated!!!!
For something to be extremely beneficial for the hair to the extent of noticeable impovment, it has to do one of the following:
Inhibit 5AR:
(ie: Finastride, Dutastride)
Manipulate Anagen phase:
(ie: Minoxidil, PP405, KY19382, Prostagladin, JAK inhibitor's)
Bind to AR:
(ie: RU-58841, Pyrilutamide, Clascoterone)
GHK-CU does neither of these so taking it for "hair benifits" is a comical stretch to me and puts in a Lower tier than fucking micro-needling
, so people claiming the hair got thicker from it are straight up lying to you because to even have noticeably thicker hair, the anagen phase will need to be manipulated, and there is 0 evidence that GHK-CU even does any of the following I have listed above.Claim number 4: "Copper Uglies"
This is something I don't even have to comment on and is just purely common sense
GHK-CU doesn't even bind to the RAR or RXR receptors responsible for causing Purging phenomenon you would see in products such as Trenton and Tazarotene.
So when people say "You skin is gonna look bad before it gets better bro" are genuinely
This purely biohacking reddit Tards spewing misinformation on a process they don't understand.
Thank you for reading y'all, dont fall for the scams !!!
