notaehw
Iron
- Joined
- Mar 20, 2026
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If you’re hating on osstivia you likely haven’t looked into it enough.
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I am not affiliated with them in any way. And in no way is this an advertisement that says anything suggesting to buy Osstivia and you will get a facial change. Nope, that isn’t shown.
so
…
The reason for this post
The dismissive cancel culture nature when this topic is brought up isn’t justified.
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THE MAIN POINT
You should want to advance evidence for anything that has mechanistic potential for aesthetic facial change.
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The mechanism is not established enough to justify confidence.
At first glance I thought they acted with upmost confidence.
But when visiting the product page and looking more into it I found they do make it clear that it’s experimental.
It’s experimental, with gaps.
They attach it to something that is more established, chewing. This may bring some hate, it looks like they are having Fructus Ligustri Lucidi (the active compound in Osstivia) take credit for results from hard chewing, this shouldn’t bring hate.
Of course there needs to be an experiment showing no hard chewing vs hard chewing alone vs hard chewing with osstivia.
Chewing is the context where osstivia makes the most sense and is advertised as a POTENTIAL (no one is claiming that it’s proven.) boost for hard chewing results. (Again, because of the nature of the discussion I have seen on this topic I have to make this clear, in no way am I saying this is for sure a boost, not even close in anything I have written)
Don’t be angry some people think buying Osstivia will change their whole face. You should be happy with the Darwinian nature of that.
It’s mechanistically plausible, and the company seems good from what I have seen. Where is the reason for the hate
The convos I have seen get shut down and dismissed.
and
There are fake screen shots of the owner saying it’s a scam, it’s so obviously fake, you can find them easily, it doesn’t take long to come to the conclusion that it was someone trying to damage the company. I also think this was involved in some weird set up.
And again the reason for this post is I think this shutting down and hate isn’t justified.
Their argument is mechanistically plausible, and you should look at the evidence yourself.
Question everything, be skeptical.
I would like to see any flaws you guys find!!
e x p i r e m e n t a l
p o t e n t i a l
u n p r o v e n
Now
THE PRODUCT DESCRIPTION
They call it experimental, but then describe the mechanism as if the facial outcome is already known.
It might have been better if they hadn’t described the mechanism as if the facial outcome is already known.
But this is a small problem.
Here it is:
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An experimental, high-bioavailability evolution of Fructus Ligustri Lucidi Extract. Osstivia utilizes a self-nano-emulsifying dietary delivery system (SNEDDS) to increase the bioavailability and permeation of lipophilic botanical compounds shown to actively promote bone growth, remodeling, increase bone density, increase osteoblast activity, and inhibit osteoclasts.
April 2026 Formula Update
Daemonorops Draco has been completely removed to make room for 3X more Fructus Ligustri Lucidi (FLL) compared to previous batches. Customers should expect even better performance and targeted results.
Beyond bone modulation, Osstivia also acts as a natural anabolic for muscle support and a great health supplement. Osstivia by itself won't magically grow bone, it is only there to increase the rate of your results and boost them. You need to pair it with a mechanical load that stimulates growth, like chewing hard gum.
THE SNEDDS ADVANTAGE
Average supplements cannot bypass first-pass metabolism and end up destroyed during digestion. We are actively advancing the science with what we have, unlike the standard supplement industry.
Straight to the Bloodstream. Ossialabs uses a Self nano-emulsifying dietary delivery system (SNEDDS) that literally increases the bioavailability and permeability of active botanical compounds. This helps bypass first-pass metabolism and leads to a good amount of the botanical compounds going straight to the bloodstream. Superior to Powders. Rat studies are mainly used to choose a botanical. While we know rats aren't similar in gut and human digestion, active botanical compounds CAN modulate pathways. By pushing SNEDDS predominantly to close that bioavailability gap, we can achieve more accurate results than just taking "powder".We Are The Human Studies. Osstivia SNEDDS is strictly experimental, and our community serves as the early human studies. It shows great promise for the people who have used it, and we plan on conducting formal studies in the future.
GROWTH MECHANISMS & SCIENCE
Important: Osstivia is both dose and time-dependent. Consistent application is required to trigger the growth pathways.
Based on data. To include preclinical:
Targeted Pathways. Osstivia acts directly on critical bone modulation pathways, including actively suppressing marrow adipogenesis and increasing ALP for mineralization. Botanical compounds can successfully modulate these pathways; even if it primarily increases cellular proliferation, it would be enough to boost chewing results. Canonical Wnt & BMP-2 Modulation. The enhanced, 3X concentrated Fructus Ligustri Lucidi in the formulation modulates canonical Wnt/β-catenin and BMP-2/Smad pathways, promoting osteoblastogenesis while decreasing osteoclast drive, Nox4/ROS, and oxidative stress. Calcium Optimization. Studies show FLL improves calcium retention, absorption, and deposition by upregulating the PTH/VDR/TRPV6 axis, creating a superior mineralization environment. Natural Anabolic Muscle Support. Osstivia contains compounds native to FLL like Ursolic Acid, Oleanolic Acid, and Salidroside. These botanical components function as a natural anabolic, providing promising evidence for supporting muscle health and function. While their role in muscle is well-supported, structural bone changes from these specific isolates are not yet heavily documented in humans.
MANDATORY SYNERGY PROTOCOL FOR FACIAL AESTHETICS
Osstivia provides the boost, but mechanical loading provides the results. For facial aesthetics and condyle growth & remodeling, hard chewing is mandatory.
30 Minute Limit. Chew for a total of 30 minutes a day. Do NOT chew for hours or constantly clench, as this leads to TMJD and has negative effects on the condyle. Cheekbone & Mandible. Hard chewing grows and remodels the condyle, which leads to improvements in the mandible. That is the growth site of the mandible, that's where growth and rotation happen, and its growth affects chin projection. You MAY potentially get zygomatic improvements since the zygomatic bones are strained when chewing, which can lead to morphological changes. The reason it might change is that chewing provides dynamic oscillative strain to surrounding sutures. Osstivia is there to increase the rate of chewing and boost chewing results, so pairing Osstivia with chewing is needed for better results. So, hard chewing with Osstivia will help with chin projection because you are growing the condyle. Growth Potential. Hypertrophic growth cartilage and condyle remodeling exist even after puberty in the mandible, so keeping bone health up definitely helps take advantage of that. If it increases proliferation, which Osstivia does, it would be enough to boost chewing results. You're not done remodeling the condyle even after your 60s. However, growth is most potent now, so take advantage of being young and hard-chewing.Timing. Take Osstivia 10–20 minutes BEFORE your hard chewing session for maximum uptake.
HOW TO CHEW CORRECTLY (HARD GUM)
Form & Focus. Open your mouth while chewing. Don’t be distracted; focus on the movement. Technique. Chew bilaterally (both sides). Position the gum, bite a couple of times, roll the gum with your tongue, and repeat. Pacing & Rest. Take rests in between. For example, chew for 1 minute, then rest for 45s–1 min. Rinse and repeat until you hit 30 minutes. Do NOT chew for more than 30 minutes total (including rest time). Keep it Tough. If the gum gets soft, use ice water and let it sit in your mouth for a couple of seconds, then resume chewing. Safety Note. If you have an overbite, contact the Craniofacial Research Collective (CRC) first before chewing.
CARE, USAGE & TASTE PROFILE
Do NOT: Do not refrigerate. Do not place near the sun. Do not put in super warm liquids. Do NOT shake if the product is already diluted. You CAN: Take Osstivia by itself or put it in water to drink. You can drink other beverages before or after taking it. You can shake the bottle before use (undiluted). Safety & Toxicology. Osstivia has had no negative side effects reported at all. The botanical compound is well-tolerated even in high amounts (though please follow the dosing guide and do not overdose). We encourage you to look into Fructus Ligustri Luciditoxicology, as extensive studies show it is remarkably safe and lacks systemic toxicity. Taste Profile. This is an advanced formulated product; it does not taste sugary or fake. Some users are sensitive to the excipients, while others don't mind. It is an acquired taste you will get used to.
NEW MEASUREMENT DOSING SYSTEM
We have upgraded from drops to a precise measurement dropper (mL). Start Low: We recommend starting at 0.5 mL and building up to the max of 2.0 mL.
Cycle Recommendation
Cycle 3 weeks ON, 1 week OFF.
HOW LONG WILL YOUR BOTTLE LAST?
DAILY DOSE
30ML BOTTLE
60ML BOTTLE
0.5 mL(Low)
2 Months
4 Months
1.0 mL
1 Month
2 Months
1.5 mL
20 Days
40 Days
2.0 mL(Max)
2 Weeks
1 Month
SCIENTIFIC REFERENCES
- Fructus ligustri lucidi ethanol extract improves bone mineral density and properties through modulating calcium absorption-related gene expression in the kidney and duodenum of growing rats. Calcif Tissue Int. (2014).
- The advances in research on the pharmacological effects of Fructus Ligustri Lucidi. Biomed Res Int. (2015).
- Improvement of bone properties and enhancement of mineralization by ethanol extract of Fructus Ligustri Lucidi. Br J Nutr. (2008).
- Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO, and Sirt6 levels in aging mice. Aging (Albany NY). (2019).
- Fructus Ligustri Lucidi preserves bone quality through induction of the canonical Wnt/β-catenin signaling pathway in ovariectomized rats. Phytother Res. (2021).
- Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems. PMC. (2024).
- Formulation development and bioavailability evaluation of a self-nanoemulsified drug delivery system of oleanolic acid. PubMed. (2009).
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You can bring your arguments and questions to the creator himself as well which is nice, he is very active on Discord, and if you have valid points he will discuss them.
You can then show screenshots disproving the potential of osstivia which would be great to see.
My position is this:
Osstivia has mechanistic potential, but that does not mean the facial outcome is proven. I’m completely open to changing my view if better evidence comes out, and I’m also open to finding flaws in Osstivia. I’m not trying to defend it blindly.
Stop shutting things down without question, we should try to advance the evidence.
Ignore my old posts, i’m trying to get better lol.
