True theoretical method, dont try it, JFL.. (HIGH IQ ONLY)
The core of the method: Simvastatin( or any other statins)
The whole idea about simvastatin (a type of statin) influencing bone growth, including the bones in your face and jaw.
1. Statins are drugs designed to block a key enzyme called HMG-CoA reductase. This enzyme is crucial for making cholesterol. When you block it, you interrupt the entire mevalonate pathway.
But here’s the twist: the mevalonate pathway doesn't just make cholesterol. It also produces other important compounds called isoprenoids. These little molecules are essential for the normal function of several proteins (like Rho and Ras) that act as cellular switches.
2.
Our growth equation:
Block Cholesterol: Simvastatin inhibits the mevalonate pathway.
Boost BMP-2: This inhibition supposedly turns on the signaling for BMP-2.
Grow Bone: BMP-2 is the master switch that activates osteoblasts (bone-building cells), telling them to rapidly produce new bone matrix, theoretically working just as well in the jaw and face as anywhere else.
Pray on BMP-2.. (JFL guide)
The core of the method: Simvastatin( or any other statins)
The Simvastatin Bone Growth Theory
The whole idea about simvastatin (a type of statin) influencing bone growth, including the bones in your face and jaw.
1. Statins are drugs designed to block a key enzyme called HMG-CoA reductase. This enzyme is crucial for making cholesterol. When you block it, you interrupt the entire mevalonate pathway.
But here’s the twist: the mevalonate pathway doesn't just make cholesterol. It also produces other important compounds called isoprenoids. These little molecules are essential for the normal function of several proteins (like Rho and Ras) that act as cellular switches.
2.
- Turbo-Charging Bone Builders (Osteoblasts): Simvastatin seemed to stimulate osteoblasts—the cells responsible for building new bone tissue. More importantly, it was hypothesized to boost the production of Bone Morphogenetic Protein-2 (BMP-2). Think of BMP-2 as the master signal that tells the body, "Hey, let's make some serious new bone right now!"
- Slowing Down Bone Breakers (Osteoclasts): By affecting those cellular switches (Rho/Ras), statins were also thought to make the bone-resorbing cells, osteoclasts, die off faster (apoptosis).
Our growth equation:
Block Cholesterol: Simvastatin inhibits the mevalonate pathway.
Boost BMP-2: This inhibition supposedly turns on the signaling for BMP-2.
Grow Bone: BMP-2 is the master switch that activates osteoblasts (bone-building cells), telling them to rapidly produce new bone matrix, theoretically working just as well in the jaw and face as anywhere else.
Pray on BMP-2.. (JFL guide)
