Hey baby,Mandy posts a guide 2 days in a row?? Wow,but Mandy will introduce you the compound that mogs all.
Increasing muscle,increasing bone formation and density and losing fat at the same time is hard to believe but it’s all in one single vial. This is the steroid everyone is afraid to run,but Mandy will assure you. You’re a virgin aren’t you? It’s time for that to no longer be,Mandy teaches you.
Introduction: What is Trenbolone?
Trenbolone to simply put it out is a 19-NOR compound derived from Nandrolone. Molecularly both compounds are similar,simply on the the same structural class. What is a 19-NOR compound in general? It’s essentially a androgenic molecule where the carbon-19 atom is non present. What does the removal of the carbon-19 atom do the molecule itself? This increases the androgen receptor binding affinity dramatically, in a simplified way it has better property to bind to an androgen receptor,causing a better binding to the androgen receptor. Trenbolone uniquely has more double bonds at Δ9, Δ11 and Δ17 especially,3 double bonds each. This great and unique feature causes a dramatically increased androgen receptor binding strength causing a better androgen receptor binding affinity,longer residence at the receptor and a better receptor ligand complex.
(Water) Trenbolone is a fully synthetic made compound,it is not present in any body naturally.
Mechanism and Action:
In terms of what trenbolone does to you,there’s so many that I barely have any motivation to finish this. But let’s not waste time and we will discuss everything.
1.IGF-1 sensitivity and increased systemic IGF-1.
Unlike any other androgen,tren increases systemic IGF-1 and does in an unusual way. It’s pretty obvious to say that IGF-1 is synthesized in the liver and it’s the liver where tren does it’s buisness with IGF-1. Since trenbolone binds to the androgen receptor way stronger than any androgen this causes the hepatic GH receptors to become more sensitized to GH, its expression upregulates become more responsive. STAT5 signaling is the main downstream signal of GH and will therefore become efficient,meaning IGF-1 transcription per unit of GH increases. Trenbolone uniquely has cortisol antagonism, we will talk about cortisol antagonism seperately but cortisol is a main factor in reducing IGF-1 transcription, MTOR signaling (downstream of IGF-1) and induces a higher amount of IGF-1 binding proteins therefore reducing its bioavalibility too. The cortisol antagonism prevents all these effects caused by cortisol itself. Trenbolone also works synergistically with insulin which improves PI3K/Akt signaling which downstreams into MTOR. With these elevated growth pathways protein synthesis is exaggerated greatly due to the fact these open pathways improves the general sensitivity of IGF-1 binding,the signaling is amplified.
2.Mineralcorticoid and glucocorticoid antagonism.
Do you hate it when your face is bloated during cycle? What’s the reason for this? Aldosterone. Excessive Aldosterone binds into a mineralcorticoid receptor and will cause stress hormones and minerals to overflow into it. What does Trenbolone do? It binds to the MCR and antagonizes it,results differ from person to person. Me personally once I added tren into my cycle my test bloat got nukes away. Trenbolone also antagonizes the glucocorticoid receptors, preventing cortisol to essentially bind to these receptors. Your cortisol levels will be the same,but the cortisol is unable to bind itself to tissue properly. This is a major factor, trenbolone is known to be the best anti-catabolic compound to exist due to this fact that cortisol is simply a catabolic hormone and preventing it’s binding will keep you in a anabolic state. Due to this, losing muscle on a cut seems impossible in these circumstances. This also contributes to the fat loss mechanism of trenbolone.
3. Nutrient partitioning.
I kid you not when I tell you that you can eat the equivelant of what an obese person eats in a day for weeks on end and still barely gain fat. This is my most favorite fact about trenbolone, it’s the Nutrient partitioning. What is Nutrient partitioning first to understand how this works. To simply put it,nutrient partitioning is how much of your calories and nutrients are directed into muscle and fat. Depending on how your nutrient partitioning is naturally,if you work out without tren your nutrient partitioning will be around a spread of 35-50% muscle and 50-60% fat depending on the surplus you’re in. Due to its constant upregulation of growth mechanisms tren will direct most of your nutrients into muscle,anything other than fat which means on tren your nutrient partitioning is 70-80% muscle and 30-20% fat. And I’m talking sedentary and active,it’s hard to gain fat on tren. The nutrient partitioning is also another part of trenbolone’s anti catabolic properties,on a cut nutrients will be absorbed and sent into muscle to prevent the essential catabolism.
4.CNS and neurotransmitter alteration
Trenbolone uniquely is highly lipophillic,meaning its CNS penetration is very potent. Its high androgenic properties and its high lipophilic properties alter your neurotransmitters significantly. Trenbolone literally has a same effect of being on adderall 24/7 especially in the first few weeks and this is due to its influence in increasing in dopaminergic tone and altering GABA and glutamate balance and something important which is increased noradrenergic signaling. The influx in total noradregergic activity directly influences lipolysis and also BMR, another good fact about fat loss and trenbolone. This causes fat loss,but also a higher blood pressure,heightened anxiety,agitation and insomnia. The dopaminergic effect is so nice because everything simply feels more satisfying,showers felt so orgasmic I took literally 4 showers a day. map
We won’t cross the simple mechanism of muscular hypertrophy,any steroid does that. I’ve named interesting and unique mechanisms,there’s still small ones that are insignificant tho.
how to use,reduce side effects etc:
People can be scared of the side effects,and I can understand that because before hopping on I was scared of trenbolone. But I then knew how to mitigate every side effect.
Night sweats? Let it be,you’ll get used to it.
Insomnia? 50mg of melatonin.
High blood pressure? 5mg bisoprolol and 20mg telmisartan.
High RBC? 100mg of aspirin.
High heart rate? Same as blood pressure.
Liver? 1800mg of NAC.
High prolactin? 200mg of P5P.
Kidney? Caused by high blood pressure, so same as the blood pressure part.
Agitation,stress? 200mg of pregabalin.
Some of these are quite questionable. 50mg melatonin? It’s not dangerous don’t worry,check out Leo and longevity on youtube. 0.5mg will be utilized for sleep,the rest is a powerful anti oxidant. Trenbolone causes lots of oxidative stress,another reason why people age a lot on tren so melatonin on tren is law. Kidney is quite controversial but I’ve figured it out,lots of renal issues are simply causes by high blood pressure,renal damage on tren is a downstream product of the hypertension you get. Treating and protecting your cardiovascular health with ß1 inhibitors is therefore so important on tren. Renal damage is not caused by the high creatinine caused by tren,high creatinine is often harmless and will reduce to normal levels after cycle,so a few weeks of high creatinine won’t effect you.
Another add in,since trenbolone exhibits progesterone activity it can create progesterone-estradiol crosstalk,increasing the sensitivity of estrogen in tissues. Now a Aromatese inhibitor does not prevent this,you’re gonna need 20mg of tamoxifen if you want to have 0% chance of gyno.
Another fact I forgot to add in,tren dosent aromatize into e2 (water)
How to dose trenbolone:
Trenbolone enanthate:
Dosage example: 100mg
Frequency: Split into 3 injection per week
Ideal administered way: Deltoid injection,Intramuscular (28g 3/8)
Trenbolone Acetate:
Dosage example: 100mg
Frequency: Split into ED/EOD injections per week
Ideal administered way: Deltoid injection,Intramuscular (28g 3/8)
Ester is no concern,tho enanthate has less risk of tren cough. A benefit of Acetate is it clears out of your system quicker in case you need to stop your cycle for some reason or generally after cycle.
Fuck nigga,I struggled harder on this than the insulin thread for some reason. Leave me a rep baby I’d appreciate and hopefully you learned everything there is to trenbolone.
Also if you want personal guidance for free:
Tags:
Biomaxx (my daddy)
Increasing muscle,increasing bone formation and density and losing fat at the same time is hard to believe but it’s all in one single vial. This is the steroid everyone is afraid to run,but Mandy will assure you. You’re a virgin aren’t you? It’s time for that to no longer be,Mandy teaches you.
Introduction: What is Trenbolone?
Trenbolone to simply put it out is a 19-NOR compound derived from Nandrolone. Molecularly both compounds are similar,simply on the the same structural class. What is a 19-NOR compound in general? It’s essentially a androgenic molecule where the carbon-19 atom is non present. What does the removal of the carbon-19 atom do the molecule itself? This increases the androgen receptor binding affinity dramatically, in a simplified way it has better property to bind to an androgen receptor,causing a better binding to the androgen receptor. Trenbolone uniquely has more double bonds at Δ9, Δ11 and Δ17 especially,3 double bonds each. This great and unique feature causes a dramatically increased androgen receptor binding strength causing a better androgen receptor binding affinity,longer residence at the receptor and a better receptor ligand complex.
(Water) Trenbolone is a fully synthetic made compound,it is not present in any body naturally.
Mechanism and Action:
In terms of what trenbolone does to you,there’s so many that I barely have any motivation to finish this. But let’s not waste time and we will discuss everything.
1.IGF-1 sensitivity and increased systemic IGF-1.
Unlike any other androgen,tren increases systemic IGF-1 and does in an unusual way. It’s pretty obvious to say that IGF-1 is synthesized in the liver and it’s the liver where tren does it’s buisness with IGF-1. Since trenbolone binds to the androgen receptor way stronger than any androgen this causes the hepatic GH receptors to become more sensitized to GH, its expression upregulates become more responsive. STAT5 signaling is the main downstream signal of GH and will therefore become efficient,meaning IGF-1 transcription per unit of GH increases. Trenbolone uniquely has cortisol antagonism, we will talk about cortisol antagonism seperately but cortisol is a main factor in reducing IGF-1 transcription, MTOR signaling (downstream of IGF-1) and induces a higher amount of IGF-1 binding proteins therefore reducing its bioavalibility too. The cortisol antagonism prevents all these effects caused by cortisol itself. Trenbolone also works synergistically with insulin which improves PI3K/Akt signaling which downstreams into MTOR. With these elevated growth pathways protein synthesis is exaggerated greatly due to the fact these open pathways improves the general sensitivity of IGF-1 binding,the signaling is amplified.
2.Mineralcorticoid and glucocorticoid antagonism.
Do you hate it when your face is bloated during cycle? What’s the reason for this? Aldosterone. Excessive Aldosterone binds into a mineralcorticoid receptor and will cause stress hormones and minerals to overflow into it. What does Trenbolone do? It binds to the MCR and antagonizes it,results differ from person to person. Me personally once I added tren into my cycle my test bloat got nukes away. Trenbolone also antagonizes the glucocorticoid receptors, preventing cortisol to essentially bind to these receptors. Your cortisol levels will be the same,but the cortisol is unable to bind itself to tissue properly. This is a major factor, trenbolone is known to be the best anti-catabolic compound to exist due to this fact that cortisol is simply a catabolic hormone and preventing it’s binding will keep you in a anabolic state. Due to this, losing muscle on a cut seems impossible in these circumstances. This also contributes to the fat loss mechanism of trenbolone.
3. Nutrient partitioning.
I kid you not when I tell you that you can eat the equivelant of what an obese person eats in a day for weeks on end and still barely gain fat. This is my most favorite fact about trenbolone, it’s the Nutrient partitioning. What is Nutrient partitioning first to understand how this works. To simply put it,nutrient partitioning is how much of your calories and nutrients are directed into muscle and fat. Depending on how your nutrient partitioning is naturally,if you work out without tren your nutrient partitioning will be around a spread of 35-50% muscle and 50-60% fat depending on the surplus you’re in. Due to its constant upregulation of growth mechanisms tren will direct most of your nutrients into muscle,anything other than fat which means on tren your nutrient partitioning is 70-80% muscle and 30-20% fat. And I’m talking sedentary and active,it’s hard to gain fat on tren. The nutrient partitioning is also another part of trenbolone’s anti catabolic properties,on a cut nutrients will be absorbed and sent into muscle to prevent the essential catabolism.
4.CNS and neurotransmitter alteration
Trenbolone uniquely is highly lipophillic,meaning its CNS penetration is very potent. Its high androgenic properties and its high lipophilic properties alter your neurotransmitters significantly. Trenbolone literally has a same effect of being on adderall 24/7 especially in the first few weeks and this is due to its influence in increasing in dopaminergic tone and altering GABA and glutamate balance and something important which is increased noradrenergic signaling. The influx in total noradregergic activity directly influences lipolysis and also BMR, another good fact about fat loss and trenbolone. This causes fat loss,but also a higher blood pressure,heightened anxiety,agitation and insomnia. The dopaminergic effect is so nice because everything simply feels more satisfying,showers felt so orgasmic I took literally 4 showers a day. map
We won’t cross the simple mechanism of muscular hypertrophy,any steroid does that. I’ve named interesting and unique mechanisms,there’s still small ones that are insignificant tho.
how to use,reduce side effects etc:
People can be scared of the side effects,and I can understand that because before hopping on I was scared of trenbolone. But I then knew how to mitigate every side effect.
Night sweats? Let it be,you’ll get used to it.
Insomnia? 50mg of melatonin.
High blood pressure? 5mg bisoprolol and 20mg telmisartan.
High RBC? 100mg of aspirin.
High heart rate? Same as blood pressure.
Liver? 1800mg of NAC.
High prolactin? 200mg of P5P.
Kidney? Caused by high blood pressure, so same as the blood pressure part.
Agitation,stress? 200mg of pregabalin.
Some of these are quite questionable. 50mg melatonin? It’s not dangerous don’t worry,check out Leo and longevity on youtube. 0.5mg will be utilized for sleep,the rest is a powerful anti oxidant. Trenbolone causes lots of oxidative stress,another reason why people age a lot on tren so melatonin on tren is law. Kidney is quite controversial but I’ve figured it out,lots of renal issues are simply causes by high blood pressure,renal damage on tren is a downstream product of the hypertension you get. Treating and protecting your cardiovascular health with ß1 inhibitors is therefore so important on tren. Renal damage is not caused by the high creatinine caused by tren,high creatinine is often harmless and will reduce to normal levels after cycle,so a few weeks of high creatinine won’t effect you.
Another add in,since trenbolone exhibits progesterone activity it can create progesterone-estradiol crosstalk,increasing the sensitivity of estrogen in tissues. Now a Aromatese inhibitor does not prevent this,you’re gonna need 20mg of tamoxifen if you want to have 0% chance of gyno.
Another fact I forgot to add in,tren dosent aromatize into e2 (water)
How to dose trenbolone:
Trenbolone enanthate:
Dosage example: 100mg
Frequency: Split into 3 injection per week
Ideal administered way: Deltoid injection,Intramuscular (28g 3/8)
Trenbolone Acetate:
Dosage example: 100mg
Frequency: Split into ED/EOD injections per week
Ideal administered way: Deltoid injection,Intramuscular (28g 3/8)
Ester is no concern,tho enanthate has less risk of tren cough. A benefit of Acetate is it clears out of your system quicker in case you need to stop your cycle for some reason or generally after cycle.
Fuck nigga,I struggled harder on this than the insulin thread for some reason. Leave me a rep baby I’d appreciate and hopefully you learned everything there is to trenbolone.
Also if you want personal guidance for free:
Tags:
Biomaxx (my daddy)
