Hello roidcels (and acnecels), today we are going to talk about topical spironolactone (and how to use it). This is a informational thread not some revolutionary new method (i'm pretty sure this info is already known jfl)
Anyways lets get into it: Topical Spironolactone is extremely effective and useful when on a steroid cycle, it counters androgenic side effects (acne, shit skin texture, anti aging) from steroids and promotes skin health.
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC8247934/
https://i.************/attachments/2025/06/5069085_1750529705567.png
Oral Spironolactone also helps with hair loss from DHT (Dihydrotestosterone). (Though I would recommend using finasteride or dutasteride for better results.)
pubmed.ncbi.nlm.nih.gov
Why topical?? Applying topical spironolactone to skin doesn't mess with your hormone levels. (Doesn't potentially nuke testosterone).
https://i.************/attachments/2025/06/5069103_1750529908735.png
Ok bhaicel but what to buy? Look for a prescription-grade topical spironolactone cream or gel (5% preferably but 2% works)
1. Clense your skin first (don't use a harsh one)
2. Apply a light drop that covers your entire face (dont use too much jfl)
3. Apply once daily (recommended at night as part of your skincare). If you use it at daytime, use SPF to prevent skin damage
(Optional) Mix with your moisturizer (make sure in the ingredients list there is niacimide or ceramides to heal the skin barrier)
Relevant studies
:
https://pmc.ncbi.nlm.nih.gov/articles/PMC5360829/
https://pubmed.ncbi.nlm.nih.gov/2147469/
https://pubmed.ncbi.nlm.nih.gov/24509960/
https://pubmed.ncbi.nlm.nih.gov/2972662/
https://pmc.ncbi.nlm.nih.gov/articles/PMC8247934/
Anyways lets get into it: Topical Spironolactone is extremely effective and useful when on a steroid cycle, it counters androgenic side effects (acne, shit skin texture, anti aging) from steroids and promotes skin health.
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC8247934/
https://i.************/attachments/2025/06/5069085_1750529705567.png
Oral Spironolactone also helps with hair loss from DHT (Dihydrotestosterone). (Though I would recommend using finasteride or dutasteride for better results.)
Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris - PubMed
The interaction between spironolactone and dihydrotestosterone (DHT) receptors was evaluated with an autoradiographic technique. The inhibition of DHT receptors by spironolactone was found to be related to the decrease of tritiated DHT granules in the sebaceous glands of the treated site. 6 male...
pubmed.ncbi.nlm.nih.gov
Why topical?? Applying topical spironolactone to skin doesn't mess with your hormone levels. (Doesn't potentially nuke testosterone).
https://i.************/attachments/2025/06/5069103_1750529908735.png
Ok bhaicel but what to buy? Look for a prescription-grade topical spironolactone cream or gel (5% preferably but 2% works)
1. Clense your skin first (don't use a harsh one)
2. Apply a light drop that covers your entire face (dont use too much jfl)
3. Apply once daily (recommended at night as part of your skincare). If you use it at daytime, use SPF to prevent skin damage
(Optional) Mix with your moisturizer (make sure in the ingredients list there is niacimide or ceramides to heal the skin barrier)
Relevant studies
:https://pmc.ncbi.nlm.nih.gov/articles/PMC5360829/
https://pubmed.ncbi.nlm.nih.gov/2147469/
https://pubmed.ncbi.nlm.nih.gov/24509960/
https://pubmed.ncbi.nlm.nih.gov/2972662/
https://pmc.ncbi.nlm.nih.gov/articles/PMC8247934/
