thoughts on transcriptional up regulation via certain steroids (2 Viewers)

[the wizard]

on my oxymetholone quest, i stumbled upon an interesting detail. many aas stimulate erythropoiesis by transcriptional upregulation, mostly in the bone marrow stromal cells. this is why anadrol was originally developed as an anemia medication. i was wondering this forums stance on this, and whether that’s a negative or positive effect for use when bodybuilding?

 

[Pxverr]

i mean it produces more red blood cels, which is good

 

[the wizard]

i mean it produces more red blood cels, which is good

yes i know, but it also causes higher blood pressure and a few cardiovascular issues

 

[oxytocins left nut]

helps your organs and oxygen transport but you risk blood clog and in rare cases even cancer

 

[Acumenis]

i mean it produces more red blood cels, which is good

More is not always better look at all the retards who had cardiovascular problem because EQ transformed their blood into honey because they had a shit ton of red blood cells

 

[the wizard]

helps your organs and oxygen transport but you risk blood clog and in rare cases even cancer

yes, the blood increases thickness and ur vo2 max may be largely effected

 

[the wizard]

More is not always better look at all the retards who had cardiovascular problem because EQ transformed their blood into honey because they had a shit ton of red blood cells

yes basal metabolic rate also increases, which is definitively linked to a shorter lifespan, but then again life ends at 30 anyways

 

[Pxverr]

Good BUT not in high amounts so keep it regulated, can cause cancer related problems and blood thickening and possible heart attacks/strokes

 

[the wizard]

Good BUT not in high amounts so keep it regulated, can cause cancer related problems and blood thickening and possible heart attacks/strokes

icl taking blood thinners while on roids might actually help but i’ve done no research so

 

[Acumenis]

yes basal metabolic rate also increases, which is definitively linked to a shorter lifespan, but then again life ends at 30 anyways

Life only ends at 30 when you are a oofy doofy

 

[the wizard]

Life only ends at 30 when you are a oofy doofy

yes i want to live forever and be a constant in the universe unwavering

 

[Pxverr]

icl taking blood thinners while on roids might actually help but i’ve done no research so

Id reccomend you do it so you lower risks

 

[the wizard]

Id reccomend you do it so you lower risks

if i do them i’d do incredibly weak ones because if i get a wound im not trying to bleed out from a paper cut

 

[Acumenis]

yes i want to live forever and be a constant in the universe unwavering

Never understood the muhhh life ends at 30 you think you wont enjoy life if you are rich , have a loving htb wife and a huge family

 

[the wizard]

Never understood the muhhh life ends at 30 you think you wont enjoy life if you are rich , have a loving htb wife and a huge family

yes, but i don’t want to fall to the agepill ever, i will definitely live past 30 though

 

[Acumenis]

yes, but i don’t want to fall to the agepill ever

Take care of yourself most normies dont even put sunscreen on and age like milk
You think rodrigo cares abt the agepill

 

[the wizard]

Take care of yourself most normies dont even put sunscreen on and age like milk
You think rodrigo cares abt the agepill

i wear sunscreen but if i really want to avoid the sun i wear a hat, 10000 spf glitch

 

[TrueIncel333]

i dont think transcriptional upregulation is inherently good or bad, it jjust depends on what genes are getting upregulated and where. with oxymetholone, the increase in erythropoiesis is nice to a point, but if youre hematocrit gets to high it starts becoming more of a cardiovascular risk than a bodybuilding benefit . its honestly kind of a double edged sword but if youre able to manage it you should be fine

 

[the wizard]

i dont think transcriptional upregulation is inherently good or bad, it jjust depends on what genes are getting upregulated and where. with oxymetholone, the increase in erythropoiesis is nice to a point, but if youre hematocrit gets to high it starts becoming more of a cardiovascular risk than a bodybuilding benefit . its honestly kind of a double edged sword but if youre able to manage it you should be fine

amazing answer any ideas to mitigate the cardiovascular risk?

 

[TrueIncel333]

amazing answer any ideas to mitigate the cardiovascular risk?

im not sure but i dont really think there is a way to completely mitigate it. from what i know once you start changing erythropoiesus theres always going to be some level of cardiovascular rick attacked

 

[the wizard]

im not sure but i dont really think there is a way to completely mitigate it. from what i know once you start changing erythropoiesus theres always going to be some level of cardiovascular rick attacked

yes i’m currently researching compounds that could act against it my best guess rn is weak blood thinners

 

[TrueIncel333]

yes i’m currently researching compounds that could act against it my best guess rn is weak blood thinners

yeah possibly. keep posting if you find any good papers

 

[the wizard]

yeah possibly. keep posting if you find any good papers

okay, rn im looking at studies with people who have genetically deformed erythropoiesis and how
doctors treat it