I know,I wasn’t talking about the dosages but general fact about AI’s. I also think AI’s are cope for prolonging epiphyseal plate fusion. Yeah many people get AI’s wrong. Even if you manage to inhibit the Aromatese enzyme,the co factor localized estradiol enzymes in the epiphyseal plate will upregulate and compensation for the lack of aromatization,such as HSD17B1, 7 and 4. This way the lack of Aromatese will be compensated by e1->e2 conversion. After a while this conversion can downregulate and eventually cause your chondrocytes to slow down proliferation.