Serious Situation is still pretty fucked (3 Viewers)

[atrophicpyra]

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All i have to say

April 21st

Anyway nothing wrong with the post just wanted opinions bec I wanted to save money on hgh

 

[atrophicpyra]

That’s not even the worst part, SARMs don’t posses about half the pathways needed for real anabolism, they are partial agonists of the AR and can’t even fully activate it, despite their high binding affinity they still suck dick when it comes to hitting the AR, (goes to show binding affinity doesn’t equal anabolic potency) also not to mention the Co receptor and co transcription factors they activate on muscle are absolute dogshit compared the the full agonism and co receptor and gene expression and co transcription factors, anabolism pathways and satellite cell activation AAS like test activate, just way way more superior in all aspects when it comes to building muscle, also the point with SARMs only being partial agonists is to “avoid androgenic side effects” whic they fucking don’t, you still ge the same shit.

They r partially agonizing other tissues like the prostate and hair skin brain but fully agonize muscle and bone which is what we care abt.

Also nobody gaf abt avoiding Androgenic side effects we want to save money and have convenience and safety

 

[atrophicpyra]

Holy shit I also missed this holy fucking mental retardation, since now tren is catabolic as well JfL

Misspell

 

[atrophicpyra]

Read the thread you’re gonna laugh harder than ever b4 I promise you.

Real SARMs user telling you his anecdotes btw, and you started with some “Muh bro he didn’t do da enclo test base method bro!”

DHT already has a higher binding affinity than test stupid nigger

Nardicus it was way WAY more retarded then what I expected.

to the surprise of absolutely no one every knowledgeable user here thinks you are a retard
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Complete DNR

Enclo rad140 works I have talked to the ppl doing it they confirm their bloodwork is fine and that enclo literally made their test levels nomal under sarms

Dht doesn’t build bone but we r both wrong it probably can under certain conditions maybe prenatal who knows

Stop bringing up newbie posts bec I can bring up retarded posts that everybody in this thread posted when they were new as well, besides some threads that were brung up weren’t even bad

- last time I’m saying this

 

[Syna]

Complete DNR

Enclo rad140 works I have talked to the ppl doing it they confirm their bloodwork is fine and that enclo literally made their test levels nomal under sarms

Dht doesn’t build bone but we r both wrong it probably can under certain conditions maybe prenatal who knows

Stop bringing up newbie posts bec I can bring up retarded posts that everybody in this thread posted when they were new as well, besides some threads that were brung up weren’t even bad

- last time I’m saying this

Not a single molecule + kys clown

 

[Syna]

They r partially agonizing other tissues like the prostate and hair skin brain but fully agonize muscle and bone which is what we care abt.

Also nobody gaf abt avoiding Androgenic side effects we want to save money and have convenience and safety

That's just you.

 

[Syna]

Complete DNR

Enclo rad140 works I have talked to the ppl doing it they confirm their bloodwork is fine and that enclo literally made their test levels nomal under sarms

Dht doesn’t build bone but we r both wrong it probably can under certain conditions maybe prenatal who knows

Stop bringing up newbie posts bec I can bring up retarded posts that everybody in this thread posted when they were new as well, besides some threads that were brung up weren’t even bad

- last time I’m saying this

sure, the opinion about some random retarded redditor > real scientfic literature and trials with RCTs and placebo, nocebo, confirmation bias and overall real variable control, ngl now that i see you crashed your E2 and are failing like 7 subjects it makes sense the type of shit you say, ngl im wondering if you even passed elementary school, cause you don't know shit about anything related to even the bases of science.

Dht doesn’t build bone but we r both wrong it probably can under certain conditions maybe prenatal who knows

It can't and why tf would it be relevant anyways?, people here were already born stupid retard.

 

[MedSlayer]

That's just you.

Yeah dude no one cares if you obtain a nw3 at 15 and get horrible acne
Gosh atrophicpyra youre so retarded youre not even a human being at this point youre destined to kys or become goycattle give up on everything its over for you

 

[Syna]

it can be used but I don't see who would, chances are you'll still be suppressed and come across the sides during week 4

Extremely brutal DNR pill

He didn't agree with you and you're yet to bring a solid argument regarding their mechanism, they have shitty ROI and get mogged by any AAS.

 

[Syna]

They r partially agonizing other tissues like the prostate and hair skin brain but fully agonize muscle and bone which is what we care abt.

Also nobody gaf abt avoiding Androgenic side effects we want to save money and have convenience and safety

not how selectivity works again.

 

[Syna]

Misspell

Yeah, it doesn't surprise me you don't posses the ability to write comprehensible coherent sentences.

 

[Syna]

threads that were brung up weren’t even bad

"dutasteride destroy bone bro!!!" "dht grows derivatives grow bones!!!" It's not the only argument i have, it just goes to show you don't posses room temperature IQ, and you just parrot anything androgenic says cause you've are not smart enough to DYOR and draw your own conclusions.

 

[Syna]

They r partially agonizing other tissues like the prostate and hair skin brain but fully agonize muscle and bone which is what we care abt.

Also nobody gaf abt avoiding Androgenic side effects we want to save money and have convenience and safety

Again, if a ligand is partially agonizing it just the describes how strong it binds to a receptor, it doesn't explain the selectivity, the selectivity doesn't come from the partial agonism to the AR, the chemical structure of SARMs are what makes them be "selective" as they interact differently with the AR than classical AAS, the co-activators SARMs activate inside the nuclei in the cell are way different than what AAS activate, hence why they don't activate the needed co activators inside certain tissues like prostate skin etc,but they do activate the needed co activators inside muscle tissue, that's where the selectivity comes from, from their chemical shape and how they twist the AR activating different co activators to trigger certain proteins and gene expression to what AAS activate, and again, their whole zero androgenic sides failed.

 

[bluesell]

Again, if a ligand is partially agonizing it just the describes how strong it binds to a receptor, it doesn't explain the selectivity, the selectivity doesn't come from the partial agonism to the AR, the chemical structure of SARMs are what makes them be "selective" as they interact differently with the AR than classical AAS, the co-activators SARMs activate inside the nuclei in the cell are way different than what AAS activate, hence why they don't activate the needed co activators inside certain tissues like prostate skin etc,but they do activate the needed co activators inside muscle tissue, that's where the selectivity comes from, from their chemical shape and how they twist the AR activating different co activators to trigger certain proteins and gene expression to what other AAS activate, an again, their whole zero androgenic sides failed.

can you respond to pm real quick

 

[Holy]

Holy

hello nigga

 

[Syna]

hello nigga

Hey

 

[Syna]

Again, if a ligand is partially agonizing it just the describes how strong it binds to a receptor, it doesn't explain the selectivity, the selectivity doesn't come from the partial agonism to the AR, the chemical structure of SARMs are what makes them be "selective" as they interact differently with the AR than classical AAS, the co-activators SARMs activate inside the nuclei in the cell are way different than what AAS activate, hence why they don't activate the needed co activators inside certain tissues like prostate skin etc,but they do activate the needed co activators inside muscle tissue, that's where the selectivity comes from, from their chemical shape and how they twist the AR activating different co activators to trigger certain proteins and gene expression to what AAS activate, and again, their whole zero androgenic sides failed.

I'm gonna go ahead and provide another example, fractional distillation of petroleum for example is a selective process, why is this? because when you heat the petroleum the temperature acts as the factor that induces selectivity, because it relies on the distinct boiling points of components within the petroleum mixture to isolate them, as you heat the petroleum in a tube to super high temperatures, the components with lower boiling points vaporize first and rise up a fractionating the column, effectively separating them, so the selectivity is determined by the different boiling points of the components of the petroleum mixture, you get it?

In SARMs the selectivity comes because of how the SARM-AR complex binds to different AREs activating different co-activators or co-repressors and different gene expression and transcription factors on the cells depending on the tissue, SARMs are not selective because they are partial agonist to the AR but because of how their chemical structure is and because they activate different AREs co-activators, co-repressors, different gene expression and transcription factors on the cells depending on the tissue.

This meaning that the altered conformation recruits a different set of coactivator or corepressor proteins in a tissue specific way, for example, in muscle and bone, coactivators are favored, promoting and prioritizing the gene transcription for protein synthesis and anabolism. In the prostate and other tissues, recruitment is weaker or favors corepressors

 

[Syna]

I'm gonna go ahead and provide another example, fractional distillation of petroleum for example is a selective process, why is this? because when you heat the petroleum the temperature acts as the factor that induces selectivity, because it relies on the distinct boiling points of components within the petroleum mixture to isolate them, as you heat the petroleum in a tube to super high temperatures, the components with lower boiling points vaporize first and rise up a fractionating the column, effectively separating them, so the selectivity is determined by the different boiling points of the components of the petroleum mixture, you get it?

In SARMs the selectivity comes because of how the SARM-AR complex binds to different AREs activating different co-activators or co-repressors and different gene expression and transcription factors on the cells depending on the tissue, SARMs are not selective because they are partial agonist to the AR but because of how their chemical structure is and because they activate different AREs co-activators, co-repressors, different gene expression and transcription factors on the cells depending on the tissue.

This meaning that the altered conformation recruits a different set of coactivator or corepressor proteins in a tissue specific way, for example, in muscle and bone, coactivators are favored, promoting and prioritizing the gene transcription for protein synthesis and anabolism. In the prostate and other tissues, recruitment is weaker or favors corepressors

INb4 muh sar ai n sheet