Serious rs2220765 igf1 receptor single nucleotide polymorphism (1 Viewer)

[atrophicpyra]

how do u get this gene in the igf1 dna tested? whats the test called and also what can this mean to my igf1 signalling if im homozygous towards it?

idc abt the longevity affect

 

[Max1umSecur1ty]

how do u get this gene in the igf1 dna tested? whats the test called and also what can this mean to my igf1 signalling if im homozygous towards it?

idc abt the longevity affect

youd need to get a snp genotyping test and being homozygous to it may help you with overall growth and metabolic processes

 

[atrophicpyra]

youd need to get a sbp genotyping test and being homozygous to it may help you with overall growth and metabolic processes

ok thank you, ill get other genes tested aswel, i hope im not homozygous to it bec it would mean less igf1 signalling

 

[Max1umSecur1ty]

ok thank you, ill get other genes tested aswel, i hope im not homozygous to it bec it would mean less igf1 signalling

np boyo good luck

 

[Dexter]

uni studies use PCR-RFLP or TaqMan assays to target this SNP
then there's obv whole exome/genome sequencing
and a single gene test, a doc can order IGF1R gene sequencing for growth disorders

if you're homozygous (AA) for IGF1 signaling, the minor allele A of rs2229765 reduces receptor function
its a 3' UTR variant. it alters microRNA binding which leads to less IGF1R expression on cell surface
so as a result your cells have lower IGF1R density
your IGF1 signaling cascade is blunted
its linked to lower serum IGF1 levels and more IGF1 bioavailability. the circulating IGF1 will be higher in your blood because there are fewer receptors to clear it
so basically you'll have a hyporesponsive IGF1R
your IGF1 signaling will be lower than someone with GG genotype