Biomaxx
Absolutely bonkers mate.
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Most people have heard of HGH and IGF-1 for increasing bone mass and potentially influencing height, but far fewer talk about PTH analogues. These compounds are designed to mimic parathyroid hormone and are typically used to treat osteoporosis, support bone resorption, and increase bone mass. Recent animal studies suggest that PTH1R agonists can enhance mandibular growth. Both abaloparatide and teriparatide have been shown to upregulate chondrogenic markers such as Sox9 and collagen II.
The interesting aspect of PTH1R agonists is that even if the facial sutures are closed, it may still be possible to see periosteal growth in the mandibular ramus and the chin. This could contribute to a wider jaw and an improved facial profile. There is evidence indicating that the mandibular condyle cartilage contains progenitor cells and proliferative layers capable of undergoing growth after adolescence.
The interesting aspect of PTH1R agonists is that even if the facial sutures are closed, it may still be possible to see periosteal growth in the mandibular ramus and the chin. This could contribute to a wider jaw and an improved facial profile. There is evidence indicating that the mandibular condyle cartilage contains progenitor cells and proliferative layers capable of undergoing growth after adolescence.

