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Guide Pharmacology Handbook PT.1 (2 Viewers)

Guide Pharmacology Handbook PT.1

greysell

Iron
Joined
Apr 15, 2026
Posts
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  • #1
Retatrutide

Retatrutide is made by Eli Lilly, its a triple agonist that targets GLP-1, GIP glucagon at the same time. GLP-1 helps you feel full and it suppresses your appetite. GIP is very important for how your body uses insulin. Glucagon is usually known for raising blood sugar but also helps burn calories. Lilly scientists changed the 39-amino acid chain so glucagon does not raise blood sugar like it normally would, but Instead, GLP-1 and GIP keep everything in check, In trials, people with obesity lost up to 24% of their body weight on 12 mg weekly, their fat dropped by about 35-40%, start at 0.5-1 mg subcutaneously weekly, jump up by 2 mg every month u`ntil reaching 12 mg per week.
Side effects: nausea, vomiting, diarrhea, injection site problems, tiredness, slight heart rate increase.




Tirzepatide

Another Eli Lilly drug, It targets GLP-1 and GIP with a stronger effect on GIP. Stays in the body for 5 days. Nigga’s thought GIP wasnt important, but Lilly found it works really well when paired with GLP-1 , FDA-approved for type 2 diabetes and obesity, people lost up to 22.5% of their weight in trials. start at 2.5 mg for a month then increase in steps: 5, 7.5, 10, 12.5, and finally 15 mg if tolerated.

Melanotan 1 & 2

Melanotan I –Targets MC1 to increase melanin production . Clears quickly with a half-life of 1-2 hours. Originally designed to prevent skin cancer. FDA approved for EPP, which helps people tolerate sunlight. Used for sunless tanning: start 0.5-1 mg for 10-14 days, then maintenance twice weekly.
Melanotan II – Targets MC1, M C3, and MC4 for tanning, appetite suppression, and increased sexual response. Very effective for ED in Phase II trials, leading to bremelanotide (Vyleesi) for women, 0.25 mg test dose, then 0.5-1 mg daily to start, then 0.5-1 mg twice weekly. Do not exceed 1 mg per dose, no need to go over 0.3mg.

Side effects for both: nausea, flushing, spontaneous boners and decreased hunger, high doses increase risk of rhabdomyolysis and acute kidney injury.
]

Anabolic Androgenic Steroids
Testosterone (Propionate , Enanthate, Cypionate, Undecanoate)


Targets androgen receptors. Converts to estradiol and DHT. Discovered in 1935 and won a Nobel prize. Medical uses: hypogonadism, delayed puberty, anemias and more,
200-600 mg a week (beginners), up to 1000 mg/week . Cycles are 8-20 weeks.


Side Effects: increased red blood cells, gyn0 (from estradiol), acne, hair loss, lower HDL and HPTA shutdown.


Trenbolone (Acetate and Enanthate)
Three times as potent as testosterone, doesnt convert to estrogen, blocks progesterone receptors and increases prolactin. Made in the 1960s for cattle, acetate 50-100 mg
daily, enanthate 200-400 mg 1-2 times weekly. Cycles: max 8-12 weeks.

Side effects: insomnia, night sweats, aggression, low HDL, high blood pressure, kidney problems and high prolactin.

Oxandrolone (Anavar)
DHT derived oral, mild and boosts strength without heavy mass, increases collagen synthesis and burns abdominal fat, No estrogen conversion. Developed in 1964 for muscle-wasting. Medical uses: weight gain after surgery or trauma and osteoporosis, 20-50 mg/day for men (split dose), women 5-10 mg/day. Cycles: 6-8 weeks.
Side effects: severely lowers HDL, mild liver stress, back pumps, HPTA suppression.
Fluoxymesterone (Halotestin)
Testosterone derivative, doesnt aromatize. Increases aggression, strength, and red blood cells without water weight or much mass. Medical uses: hypogonadism, delayed puberty and breast cancer, 10-30 mg/day (split), max 6 weeks. Beginners: 10 mg.
Side Effects: very hepatotoxic, crushes HDL, extreme aggression/mood swings, severe back pumps, full HPTA suppression. Use only short-term before competing.
Methasterone (Superdrol)

DHT-derived oral (2a,17a-dimethyl). Gives dry lean mass without water retention, designer steroid, 10-20 mg/day, max 4 weeks. First-time: 10 mg. Never exceed 35 mg.

Side effects: severe appetite suppression, extreme lethargy (many quit by week 3), liver enzymes soar, HDL lowers, no estrogen conversion, complete HPTA suppression within 10 days.
Oxymetholone (Anadrol / A-50)

DHT-derived oral. Works via ERK signaling and increased erythropoietin (EPO). Rapid mass and strength gains (water, glycogen, then tissue). Medical uses: anemia, HIV wasting. 25-50 mg/day (beginners), 50-100 mg/day (advanced). Cycles: 4-6 weeks.

Side effects: estrogen-like sides (water retention, high BP, possibly gyn0) even without conversion, hepatotoxic, HDL, back pumps, headaches.
Dianabol / Dbol
Testosterone with 17alpha alkylation. Aromatizes heavily into methyl-estradiol (potent estrogen). No US FDA approval (withdrawn). 15-30 mg/day and 30-50 mg/day (advanced). Cycles: 4-6 weeks

Side effects: high BP from water retention, gyn0, significant liver strain, lethargy.
YK-11
YK-11
is a myostatin inhibitor, setting it apart from traditional SARMs . Myostatin acts as a natural limiter of muscle growth. By inhibiting myostatin, YK-11 may allow for increased muscle growth beyond what typical androgen receptor activation provides . It is still in early stages of scientific exploration .
5 mg/day to start ( to test tolerance), then up to 10-15 mg/day if needed .
Cycle length: 4-8 weeks, then take a break thats equal to cycle length .

Side effects :
Testosterone suppression
Liver stress
Joint or tendon pain
Hair loss or acne from hormonal changes
Mood fluctuations
HCG (Human Chorionic Gonadotropin)

Acts like LH and stimulate Leydig cells to produce testosterone. Preserves testicular size when exogenous testosterone shuts down natural production. Medical uses: hypogonadism, undescended balls, female ovulation induction. Cycle support: 250-500 IU subcutanously 2-3 times weekly. PCT: 1000-2000 IU every other day for 3-4 weeks, then switch to a SERM.
Side effects: increased estrogen (possible gyn0), high long-term doses may "burn out" Leydig cells.







Growth Peptides

HGH (Somatropin)
Targets GHR, activates the JAK2-STAT5 pathway in your liver and boosts IGF-1. Before 1985 it was extracted from cadaver pituitary glands. FDA-approved for GH deficiency, Turner syndrome, kidney problems, HIV wasting. 3-6 IU (0.66-2 mg) subcutaneously daily for 3-6 months. Dont exceed 10 IU for a prolonged period.


Side effects: acromegaly, carpal tunnel, insulin resistance, water retention and pain in your joints

MK-677 (Ibutamoren)
Oral ghrelin

receptor agonist (GHSR-1a). It imitates ghrelin to release GH and IGF-1 continuously (not in pulses). Developed by Merck for GH deficiency and frailty. Raises IGF-1 by 60-80% without injections. . 10-25 mg orally at night on an empty stomach. Run for 6-12 months, Side effects: increased hunger, water retention (puffy face and numb hands), insulin resistance (raised fasting glucose), lethargy, mild prolactin/cortisol increase. Avoid if your diabetic.
GHRP-2 (Growth Hormone Releasing Peptide-2)Synthetic GHSR agonist that stimulates GH release. Has very low oral availability (0.30-1.0%) and a short half-life: half an hour . Medical uses studied: increasing growth velocity in children, increasing appetite, weight gain , normalizing IGF-1 in critical illness . Off-label: 100-300 mcg subcutaneously 1-3 times daily.
Side effects: transient increase in appetite and cortisol .
GHRP-6
Synthetic GHSR agonist similar to GHRP-2. Oral availability is very low (0.30%) with a half-life of 0.30 hours . Studied medical uses: restoration of GH secretion in obesity, increased time in stage 2 sleep . Off-label: 100-300 mcg subcutaneously 1-3 times daily.
Side effects: transient increase in cortisol .

GHK-Cu


Peptide bonded to copper. Helps collagen and acts as an antioxidant, found in blood in 1973. Levels can drop from ~200 ng/mL at age 20 to around 80 ng/mL by age 60. Clinical use: wound healing, skin improvement. Off-label: 2-5 mg subcutaneously 2-3 times weekly for 8-12 weeks.

Side effects: redness or metallic taste .



Ipamorelin-

Targets GHSR to release GH without spiking cortisol or prolactin. Dropped because oral delivery fails, 200-300 mcg subcutaneously 2-3 times daily, or 400-600 mcg at night. Cycles: 12-16 weeks then 4 weeks off.
Side effects: mild headache or flushing. No hunger increase, no cortisol spike.
(Tesamorelin)

DPP-4-resistant GHRH analog. Releases GH in pulsed manner, increases IGF-1, reduces visceral fat. FDA-approved for HIV lipodystrophy. Off-label: 1-2 mg daily for 12-24 weeks.

Side effects: injection site problems, joint aches, swelling, high blood sugar.


CJC-1295 with DAC

GHRH analog that binds to albumin (half life is 6-8 days). Double-edged sword, hard to stop if problems arise. 1-2 mg subcutaneously twice weekly, often stacked with a GHRP like ipamorelin. Cycles: 6-12 months.
Side effects: injection pain, carpal tunnel, insulin resistance.
GHSR-1a agonist just like GHRP-2. Oral availability is also very low (0.30%) with a half-life of .30 hours . Studied medical uses: restoration of GH secretion in obesity, increased time in stage 2 sleep , 100-300 mcg 1-3 times daily.
Hexarelin

Hexarelin is a GHSR-1a agonist that releases GH, prolactin, cortisol and increases hunger. It has some heart protection benefits via PI3K-Akt, in heart cells,It was tested for GH deficiency and heart problems. Off-label people use it for muscle or fat tweaks.

Dosing is 200-400 micrograms which is under the skin 2-3 times a day. You do this for 4-6 weeks then you stop it for 4 weeks to avoid your body getting too used to it.
The thing is, you might feel really hungry, your cortisol levels will go up your prolactin levels will go up your body could get used to it. You could feel some tingles or numbness.

Peptides for Repairing and Regenerating

BPC-157

works by increasing VEGF , FGF2 and eNOS so new blood vessels can grow. It also affects oxide and prostaglandins. The weird thing is they found it by accident when they were studying stomach juices. At first it helped fix stomach ulcers in rats then it helped with liver problems that were caused by drinking and it even helped with nerve damage all in the same animals.
In settings it is being looked at for inflammatory bowel disease and tendonitis.. People also like to use it off-label to help heal injuries, especially for tendons and ligaments.

The dosing for BPC-157 is 250-500 micrograms subcutaneously 1-2 times a day. If you are really hurt you can do 500-1000 micrograms, 2-3 times a day. You do this for 4-12 weeks.
The side effects are not that bad. You might get a headache. There is a risk of tumors but there isnt proof.

TB-500, also known as Thymosin Beta-4

works by binding to G-actin, which helps cells move around and create blood vessels and it also reduces inflammation. When you cut yourself TB-4 helps fix the cut.
In settings it is being looked at for wound care and heart repair, used to help muscles, tendons and ligaments recover, start with a dose of 5-10 milligrams subcutaneously or intramuscularly twice a week for 4-6 weeks. Then you reduce the dose to 2-5 milligrams, twice a week for maintenance.

The side effects arent usually a problem, Sometimes you might feel tired or get a headache.


Insulin Resistance | HGH, MK-677, Tesamorelin | Berberine 500 mg with carbs (max 1500 mg/day), or Metformin 500-1000 mg/day | Fasting glucose, HbA1c,
Chromium picolinate 200-400 mcg/day, R-ALA 300-600 mg/day
Water Retention | HGH, Test (E2), Tren | More potassium (avocados, KCl), dandelion root 500-1000 mg, furosemide and/or telmisartan 20-40 mg | Blood pressure, daily weight
High Prolactin | Tren, Deca, hexarelin | P-5-P 100-200 mg/day or Cabergoline 0.25 mg twice a week (Rx) | Serum prolactin (<15 ng/mL)
Hematocrit Up | Testosterone, Tren | Donate blood if Hct over 52%, stay hydrated, aspirin 81 mg if Hct over 54% | CBC every 3 months
GI Upset | GLP-1 agonists | 500-1000 mg ginger root, split your weekly dose into two shots
Low HDL | AAS (esp. Tren), GH | Citrus Bergamot 500-1000 mg, Omega-3 4 g daily | Lipid panel, ApoB
Blood Pressure Rising | Fluid retention, AAS | Telmisartan 20-80 mg/day, add amlodipine 5-10 mg if needed | Home BP (goal under 130/80)
Gyn0 | Aromatizing AAS, HCG | Anastrozole 0.25-0.5 mg every three days, Tamoxifen 10-20 mg daily | Serum E2, clinical check, Raloxifene 60 mg/day (for existing gyn0 reduction)
HPTA Suppression | All AAS, especially 19-nors | PCT: HCG 1000-2000 IU EOD ×3 weeks → Clomid 50 mg + Tamoxifene 20 mg ×4 weeks | LH, FSH, total T (check 4 weeks after PCT)
 

fent

Serial Heightmaxxer
Joined
Jan 19, 2026
Posts
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  • #2
Retatrutide

Retatrutide is made by Eli Lilly, its a triple agonist that targets GLP-1, GIP glucagon at the same time. GLP-1 helps you feel full and it suppresses your appetite. GIP is very important for how your body uses insulin. Glucagon is usually known for raising blood sugar but also helps burn calories. Lilly scientists changed the 39-amino acid chain so glucagon does not raise blood sugar like it normally would, but Instead, GLP-1 and GIP keep everything in check, In trials, people with obesity lost up to 24% of their body weight on 12 mg weekly, their fat dropped by about 35-40%, start at 0.5-1 mg subcutaneously weekly, jump up by 2 mg every month u`ntil reaching 12 mg per week.
Side effects: nausea, vomiting, diarrhea, injection site problems, tiredness, slight heart rate increase.




Tirzepatide

Another Eli Lilly drug, It targets GLP-1 and GIP with a stronger effect on GIP. Stays in the body for 5 days. Nigga’s thought GIP wasnt important, but Lilly found it works really well when paired with GLP-1 , FDA-approved for type 2 diabetes and obesity, people lost up to 22.5% of their weight in trials. start at 2.5 mg for a month then increase in steps: 5, 7.5, 10, 12.5, and finally 15 mg if tolerated.

Melanotan 1 & 2

Melanotan I –Targets MC1 to increase melanin production . Clears quickly with a half-life of 1-2 hours. Originally designed to prevent skin cancer. FDA approved for EPP, which helps people tolerate sunlight. Used for sunless tanning: start 0.5-1 mg for 10-14 days, then maintenance twice weekly.
Melanotan II – Targets MC1, M C3, and MC4 for tanning, appetite suppression, and increased sexual response. Very effective for ED in Phase II trials, leading to bremelanotide (Vyleesi) for women, 0.25 mg test dose, then 0.5-1 mg daily to start, then 0.5-1 mg twice weekly. Do not exceed 1 mg per dose, no need to go over 0.3mg.

Side effects for both: nausea, flushing, spontaneous boners and decreased hunger, high doses increase risk of rhabdomyolysis and acute kidney injury.
]

Anabolic Androgenic Steroids
Testosterone (Propionate , Enanthate, Cypionate, Undecanoate)


Targets androgen receptors. Converts to estradiol and DHT. Discovered in 1935 and won a Nobel prize. Medical uses: hypogonadism, delayed puberty, anemias and more,
200-600 mg a week (beginners), up to 1000 mg/week . Cycles are 8-20 weeks.


Side Effects: increased red blood cells, gyn0 (from estradiol), acne, hair loss, lower HDL and HPTA shutdown.


Trenbolone (Acetate and Enanthate)
Three times as potent as testosterone, doesnt convert to estrogen, blocks progesterone receptors and increases prolactin. Made in the 1960s for cattle, acetate 50-100 mg
daily, enanthate 200-400 mg 1-2 times weekly. Cycles: max 8-12 weeks.

Side effects: insomnia, night sweats, aggression, low HDL, high blood pressure, kidney problems and high prolactin.

Oxandrolone (Anavar)
DHT derived oral, mild and boosts strength without heavy mass, increases collagen synthesis and burns abdominal fat, No estrogen conversion. Developed in 1964 for muscle-wasting. Medical uses: weight gain after surgery or trauma and osteoporosis, 20-50 mg/day for men (split dose), women 5-10 mg/day. Cycles: 6-8 weeks.
Side effects: severely lowers HDL, mild liver stress, back pumps, HPTA suppression.
Fluoxymesterone (Halotestin)
Testosterone derivative, doesnt aromatize. Increases aggression, strength, and red blood cells without water weight or much mass. Medical uses: hypogonadism, delayed puberty and breast cancer, 10-30 mg/day (split), max 6 weeks. Beginners: 10 mg.
Side Effects: very hepatotoxic, crushes HDL, extreme aggression/mood swings, severe back pumps, full HPTA suppression. Use only short-term before competing.
Methasterone (Superdrol)

DHT-derived oral (2a,17a-dimethyl). Gives dry lean mass without water retention, designer steroid, 10-20 mg/day, max 4 weeks. First-time: 10 mg. Never exceed 35 mg.

Side effects: severe appetite suppression, extreme lethargy (many quit by week 3), liver enzymes soar, HDL lowers, no estrogen conversion, complete HPTA suppression within 10 days.
Oxymetholone (Anadrol / A-50)

DHT-derived oral. Works via ERK signaling and increased erythropoietin (EPO). Rapid mass and strength gains (water, glycogen, then tissue). Medical uses: anemia, HIV wasting. 25-50 mg/day (beginners), 50-100 mg/day (advanced). Cycles: 4-6 weeks.

Side effects: estrogen-like sides (water retention, high BP, possibly gyn0) even without conversion, hepatotoxic, HDL, back pumps, headaches.
Dianabol / Dbol
Testosterone with 17alpha alkylation. Aromatizes heavily into methyl-estradiol (potent estrogen). No US FDA approval (withdrawn). 15-30 mg/day and 30-50 mg/day (advanced). Cycles: 4-6 weeks

Side effects: high BP from water retention, gyn0, significant liver strain, lethargy.
YK-11
YK-11
is a myostatin inhibitor, setting it apart from traditional SARMs . Myostatin acts as a natural limiter of muscle growth. By inhibiting myostatin, YK-11 may allow for increased muscle growth beyond what typical androgen receptor activation provides . It is still in early stages of scientific exploration .
5 mg/day to start ( to test tolerance), then up to 10-15 mg/day if needed .
Cycle length: 4-8 weeks, then take a break thats equal to cycle length .

Side effects :
Testosterone suppression
Liver stress
Joint or tendon pain
Hair loss or acne from hormonal changes
Mood fluctuations
HCG (Human Chorionic Gonadotropin)

Acts like LH and stimulate Leydig cells to produce testosterone. Preserves testicular size when exogenous testosterone shuts down natural production. Medical uses: hypogonadism, undescended balls, female ovulation induction. Cycle support: 250-500 IU subcutanously 2-3 times weekly. PCT: 1000-2000 IU every other day for 3-4 weeks, then switch to a SERM.
Side effects: increased estrogen (possible gyn0), high long-term doses may "burn out" Leydig cells.







Growth Peptides

HGH (Somatropin)
Targets GHR, activates the JAK2-STAT5 pathway in your liver and boosts IGF-1. Before 1985 it was extracted from cadaver pituitary glands. FDA-approved for GH deficiency, Turner syndrome, kidney problems, HIV wasting. 3-6 IU (0.66-2 mg) subcutaneously daily for 3-6 months. Dont exceed 10 IU for a prolonged period.


Side effects: acromegaly, carpal tunnel, insulin resistance, water retention and pain in your joints

MK-677 (Ibutamoren)
Oral ghrelin

receptor agonist (GHSR-1a). It imitates ghrelin to release GH and IGF-1 continuously (not in pulses). Developed by Merck for GH deficiency and frailty. Raises IGF-1 by 60-80% without injections. . 10-25 mg orally at night on an empty stomach. Run for 6-12 months, Side effects: increased hunger, water retention (puffy face and numb hands), insulin resistance (raised fasting glucose), lethargy, mild prolactin/cortisol increase. Avoid if your diabetic.
GHRP-2 (Growth Hormone Releasing Peptide-2)Synthetic GHSR agonist that stimulates GH release. Has very low oral availability (0.30-1.0%) and a short half-life: half an hour . Medical uses studied: increasing growth velocity in children, increasing appetite, weight gain , normalizing IGF-1 in critical illness . Off-label: 100-300 mcg subcutaneously 1-3 times daily.
Side effects: transient increase in appetite and cortisol .
GHRP-6
Synthetic GHSR agonist similar to GHRP-2. Oral availability is very low (0.30%) with a half-life of 0.30 hours . Studied medical uses: restoration of GH secretion in obesity, increased time in stage 2 sleep . Off-label: 100-300 mcg subcutaneously 1-3 times daily.
Side effects: transient increase in cortisol .

GHK-Cu


Peptide bonded to copper. Helps collagen and acts as an antioxidant, found in blood in 1973. Levels can drop from ~200 ng/mL at age 20 to around 80 ng/mL by age 60. Clinical use: wound healing, skin improvement. Off-label: 2-5 mg subcutaneously 2-3 times weekly for 8-12 weeks.

Side effects: redness or metallic taste .



Ipamorelin-

Targets GHSR to release GH without spiking cortisol or prolactin. Dropped because oral delivery fails, 200-300 mcg subcutaneously 2-3 times daily, or 400-600 mcg at night. Cycles: 12-16 weeks then 4 weeks off.
Side effects: mild headache or flushing. No hunger increase, no cortisol spike.
(Tesamorelin)

DPP-4-resistant GHRH analog. Releases GH in pulsed manner, increases IGF-1, reduces visceral fat. FDA-approved for HIV lipodystrophy. Off-label: 1-2 mg daily for 12-24 weeks.

Side effects: injection site problems, joint aches, swelling, high blood sugar.


CJC-1295 with DAC

GHRH analog that binds to albumin (half life is 6-8 days). Double-edged sword, hard to stop if problems arise. 1-2 mg subcutaneously twice weekly, often stacked with a GHRP like ipamorelin. Cycles: 6-12 months.
Side effects: injection pain, carpal tunnel, insulin resistance.
GHSR-1a agonist just like GHRP-2. Oral availability is also very low (0.30%) with a half-life of .30 hours . Studied medical uses: restoration of GH secretion in obesity, increased time in stage 2 sleep , 100-300 mcg 1-3 times daily.
Hexarelin

Hexarelin is a GHSR-1a agonist that releases GH, prolactin, cortisol and increases hunger. It has some heart protection benefits via PI3K-Akt, in heart cells,It was tested for GH deficiency and heart problems. Off-label people use it for muscle or fat tweaks.

Dosing is 200-400 micrograms which is under the skin 2-3 times a day. You do this for 4-6 weeks then you stop it for 4 weeks to avoid your body getting too used to it.
The thing is, you might feel really hungry, your cortisol levels will go up your prolactin levels will go up your body could get used to it. You could feel some tingles or numbness.

Peptides for Repairing and Regenerating

BPC-157

works by increasing VEGF , FGF2 and eNOS so new blood vessels can grow. It also affects oxide and prostaglandins. The weird thing is they found it by accident when they were studying stomach juices. At first it helped fix stomach ulcers in rats then it helped with liver problems that were caused by drinking and it even helped with nerve damage all in the same animals.
In settings it is being looked at for inflammatory bowel disease and tendonitis.. People also like to use it off-label to help heal injuries, especially for tendons and ligaments.

The dosing for BPC-157 is 250-500 micrograms subcutaneously 1-2 times a day. If you are really hurt you can do 500-1000 micrograms, 2-3 times a day. You do this for 4-12 weeks.
The side effects are not that bad. You might get a headache. There is a risk of tumors but there isnt proof.

TB-500, also known as Thymosin Beta-4

works by binding to G-actin, which helps cells move around and create blood vessels and it also reduces inflammation. When you cut yourself TB-4 helps fix the cut.
In settings it is being looked at for wound care and heart repair, used to help muscles, tendons and ligaments recover, start with a dose of 5-10 milligrams subcutaneously or intramuscularly twice a week for 4-6 weeks. Then you reduce the dose to 2-5 milligrams, twice a week for maintenance.

The side effects arent usually a problem, Sometimes you might feel tired or get a headache.


Insulin Resistance | HGH, MK-677, Tesamorelin | Berberine 500 mg with carbs (max 1500 mg/day), or Metformin 500-1000 mg/day | Fasting glucose, HbA1c,
Chromium picolinate 200-400 mcg/day, R-ALA 300-600 mg/day
Water Retention | HGH, Test (E2), Tren | More potassium (avocados, KCl), dandelion root 500-1000 mg, furosemide and/or telmisartan 20-40 mg | Blood pressure, daily weight
High Prolactin | Tren, Deca, hexarelin | P-5-P 100-200 mg/day or Cabergoline 0.25 mg twice a week (Rx) | Serum prolactin (<15 ng/mL)
Hematocrit Up | Testosterone, Tren | Donate blood if Hct over 52%, stay hydrated, aspirin 81 mg if Hct over 54% | CBC every 3 months
GI Upset | GLP-1 agonists | 500-1000 mg ginger root, split your weekly dose into two shots
Low HDL | AAS (esp. Tren), GH | Citrus Bergamot 500-1000 mg, Omega-3 4 g daily | Lipid panel, ApoB
Blood Pressure Rising | Fluid retention, AAS | Telmisartan 20-80 mg/day, add amlodipine 5-10 mg if needed | Home BP (goal under 130/80)
Gyn0 | Aromatizing AAS, HCG | Anastrozole 0.25-0.5 mg every three days, Tamoxifen 10-20 mg daily | Serum E2, clinical check, Raloxifene 60 mg/day (for existing gyn0 reduction)
HPTA Suppression | All AAS, especially 19-nors | PCT: HCG 1000-2000 IU EOD ×3 weeks → Clomid 50 mg + Tamoxifene 20 mg ×4 weeks | LH, FSH, total T (check 4 weeks after PCT)
skimmed it, will read fully tn. Mirin
 
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  • #3
there should be some anti tanning agents aswell easily available as well man 💔
 

quertzlynx

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  • #4
mirin
 

greysell

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  • #5

Razi

Lame guy • gone spiritmaxxing
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  • #6
Very nice will def be a good read
 

Peace

𝙖𝙣𝙙 𝙇𝙤𝙫𝙚
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  • #7
mirin hard :kim:
 

GeneticLotteryLoser

rooftop koreans tuff asf
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  • #8
mirin
 

greysell

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  • #9
Retatrutide

Retatrutide is made by Eli Lilly, its a triple agonist that targets GLP-1, GIP glucagon at the same time. GLP-1 helps you feel full and it suppresses your appetite. GIP is very important for how your body uses insulin. Glucagon is usually known for raising blood sugar but also helps burn calories. Lilly scientists changed the 39-amino acid chain so glucagon does not raise blood sugar like it normally would, but Instead, GLP-1 and GIP keep everything in check, In trials, people with obesity lost up to 24% of their body weight on 12 mg weekly, their fat dropped by about 35-40%, start at 0.5-1 mg subcutaneously weekly, jump up by 2 mg every month u`ntil reaching 12 mg per week.
Side effects: nausea, vomiting, diarrhea, injection site problems, tiredness, slight heart rate increase.




Tirzepatide

Another Eli Lilly drug, It targets GLP-1 and GIP with a stronger effect on GIP. Stays in the body for 5 days. Nigga’s thought GIP wasnt important, but Lilly found it works really well when paired with GLP-1 , FDA-approved for type 2 diabetes and obesity, people lost up to 22.5% of their weight in trials. start at 2.5 mg for a month then increase in steps: 5, 7.5, 10, 12.5, and finally 15 mg if tolerated.

Melanotan 1 & 2

Melanotan I –Targets MC1 to increase melanin production . Clears quickly with a half-life of 1-2 hours. Originally designed to prevent skin cancer. FDA approved for EPP, which helps people tolerate sunlight. Used for sunless tanning: start 0.5-1 mg for 10-14 days, then maintenance twice weekly.
Melanotan II – Targets MC1, M C3, and MC4 for tanning, appetite suppression, and increased sexual response. Very effective for ED in Phase II trials, leading to bremelanotide (Vyleesi) for women, 0.25 mg test dose, then 0.5-1 mg daily to start, then 0.5-1 mg twice weekly. Do not exceed 1 mg per dose, no need to go over 0.3mg.

Side effects for both: nausea, flushing, spontaneous boners and decreased hunger, high doses increase risk of rhabdomyolysis and acute kidney injury.
]

Anabolic Androgenic Steroids
Testosterone (Propionate , Enanthate, Cypionate, Undecanoate)


Targets androgen receptors. Converts to estradiol and DHT. Discovered in 1935 and won a Nobel prize. Medical uses: hypogonadism, delayed puberty, anemias and more,
200-600 mg a week (beginners), up to 1000 mg/week . Cycles are 8-20 weeks.


Side Effects: increased red blood cells, gyn0 (from estradiol), acne, hair loss, lower HDL and HPTA shutdown.


Trenbolone (Acetate and Enanthate)
Three times as potent as testosterone, doesnt convert to estrogen, blocks progesterone receptors and increases prolactin. Made in the 1960s for cattle, acetate 50-100 mg
daily, enanthate 200-400 mg 1-2 times weekly. Cycles: max 8-12 weeks.

Side effects: insomnia, night sweats, aggression, low HDL, high blood pressure, kidney problems and high prolactin.

Oxandrolone (Anavar)
DHT derived oral, mild and boosts strength without heavy mass, increases collagen synthesis and burns abdominal fat, No estrogen conversion. Developed in 1964 for muscle-wasting. Medical uses: weight gain after surgery or trauma and osteoporosis, 20-50 mg/day for men (split dose), women 5-10 mg/day. Cycles: 6-8 weeks.
Side effects: severely lowers HDL, mild liver stress, back pumps, HPTA suppression.
Fluoxymesterone (Halotestin)
Testosterone derivative, doesnt aromatize. Increases aggression, strength, and red blood cells without water weight or much mass. Medical uses: hypogonadism, delayed puberty and breast cancer, 10-30 mg/day (split), max 6 weeks. Beginners: 10 mg.
Side Effects: very hepatotoxic, crushes HDL, extreme aggression/mood swings, severe back pumps, full HPTA suppression. Use only short-term before competing.
Methasterone (Superdrol)

DHT-derived oral (2a,17a-dimethyl). Gives dry lean mass without water retention, designer steroid, 10-20 mg/day, max 4 weeks. First-time: 10 mg. Never exceed 35 mg.

Side effects: severe appetite suppression, extreme lethargy (many quit by week 3), liver enzymes soar, HDL lowers, no estrogen conversion, complete HPTA suppression within 10 days.
Oxymetholone (Anadrol / A-50)

DHT-derived oral. Works via ERK signaling and increased erythropoietin (EPO). Rapid mass and strength gains (water, glycogen, then tissue). Medical uses: anemia, HIV wasting. 25-50 mg/day (beginners), 50-100 mg/day (advanced). Cycles: 4-6 weeks.

Side effects: estrogen-like sides (water retention, high BP, possibly gyn0) even without conversion, hepatotoxic, HDL, back pumps, headaches.
Dianabol / Dbol
Testosterone with 17alpha alkylation. Aromatizes heavily into methyl-estradiol (potent estrogen). No US FDA approval (withdrawn). 15-30 mg/day and 30-50 mg/day (advanced). Cycles: 4-6 weeks

Side effects: high BP from water retention, gyn0, significant liver strain, lethargy.
YK-11
YK-11
is a myostatin inhibitor, setting it apart from traditional SARMs . Myostatin acts as a natural limiter of muscle growth. By inhibiting myostatin, YK-11 may allow for increased muscle growth beyond what typical androgen receptor activation provides . It is still in early stages of scientific exploration .
5 mg/day to start ( to test tolerance), then up to 10-15 mg/day if needed .
Cycle length: 4-8 weeks, then take a break thats equal to cycle length .

Side effects :
Testosterone suppression
Liver stress
Joint or tendon pain
Hair loss or acne from hormonal changes
Mood fluctuations
HCG (Human Chorionic Gonadotropin)

Acts like LH and stimulate Leydig cells to produce testosterone. Preserves testicular size when exogenous testosterone shuts down natural production. Medical uses: hypogonadism, undescended balls, female ovulation induction. Cycle support: 250-500 IU subcutanously 2-3 times weekly. PCT: 1000-2000 IU every other day for 3-4 weeks, then switch to a SERM.
Side effects: increased estrogen (possible gyn0), high long-term doses may "burn out" Leydig cells.







Growth Peptides

HGH (Somatropin)
Targets GHR, activates the JAK2-STAT5 pathway in your liver and boosts IGF-1. Before 1985 it was extracted from cadaver pituitary glands. FDA-approved for GH deficiency, Turner syndrome, kidney problems, HIV wasting. 3-6 IU (0.66-2 mg) subcutaneously daily for 3-6 months. Dont exceed 10 IU for a prolonged period.


Side effects: acromegaly, carpal tunnel, insulin resistance, water retention and pain in your joints

MK-677 (Ibutamoren)
Oral ghrelin

receptor agonist (GHSR-1a). It imitates ghrelin to release GH and IGF-1 continuously (not in pulses). Developed by Merck for GH deficiency and frailty. Raises IGF-1 by 60-80% without injections. . 10-25 mg orally at night on an empty stomach. Run for 6-12 months, Side effects: increased hunger, water retention (puffy face and numb hands), insulin resistance (raised fasting glucose), lethargy, mild prolactin/cortisol increase. Avoid if your diabetic.
GHRP-2 (Growth Hormone Releasing Peptide-2)Synthetic GHSR agonist that stimulates GH release. Has very low oral availability (0.30-1.0%) and a short half-life: half an hour . Medical uses studied: increasing growth velocity in children, increasing appetite, weight gain , normalizing IGF-1 in critical illness . Off-label: 100-300 mcg subcutaneously 1-3 times daily.
Side effects: transient increase in appetite and cortisol .
GHRP-6
Synthetic GHSR agonist similar to GHRP-2. Oral availability is very low (0.30%) with a half-life of 0.30 hours . Studied medical uses: restoration of GH secretion in obesity, increased time in stage 2 sleep . Off-label: 100-300 mcg subcutaneously 1-3 times daily.
Side effects: transient increase in cortisol .

GHK-Cu


Peptide bonded to copper. Helps collagen and acts as an antioxidant, found in blood in 1973. Levels can drop from ~200 ng/mL at age 20 to around 80 ng/mL by age 60. Clinical use: wound healing, skin improvement. Off-label: 2-5 mg subcutaneously 2-3 times weekly for 8-12 weeks.

Side effects: redness or metallic taste .



Ipamorelin-

Targets GHSR to release GH without spiking cortisol or prolactin. Dropped because oral delivery fails, 200-300 mcg subcutaneously 2-3 times daily, or 400-600 mcg at night. Cycles: 12-16 weeks then 4 weeks off.
Side effects: mild headache or flushing. No hunger increase, no cortisol spike.
(Tesamorelin)

DPP-4-resistant GHRH analog. Releases GH in pulsed manner, increases IGF-1, reduces visceral fat. FDA-approved for HIV lipodystrophy. Off-label: 1-2 mg daily for 12-24 weeks.

Side effects: injection site problems, joint aches, swelling, high blood sugar.


CJC-1295 with DAC

GHRH analog that binds to albumin (half life is 6-8 days). Double-edged sword, hard to stop if problems arise. 1-2 mg subcutaneously twice weekly, often stacked with a GHRP like ipamorelin. Cycles: 6-12 months.
Side effects: injection pain, carpal tunnel, insulin resistance.
GHSR-1a agonist just like GHRP-2. Oral availability is also very low (0.30%) with a half-life of .30 hours . Studied medical uses: restoration of GH secretion in obesity, increased time in stage 2 sleep , 100-300 mcg 1-3 times daily.
Hexarelin

Hexarelin is a GHSR-1a agonist that releases GH, prolactin, cortisol and increases hunger. It has some heart protection benefits via PI3K-Akt, in heart cells,It was tested for GH deficiency and heart problems. Off-label people use it for muscle or fat tweaks.

Dosing is 200-400 micrograms which is under the skin 2-3 times a day. You do this for 4-6 weeks then you stop it for 4 weeks to avoid your body getting too used to it.
The thing is, you might feel really hungry, your cortisol levels will go up your prolactin levels will go up your body could get used to it. You could feel some tingles or numbness.

Peptides for Repairing and Regenerating

BPC-157

works by increasing VEGF , FGF2 and eNOS so new blood vessels can grow. It also affects oxide and prostaglandins. The weird thing is they found it by accident when they were studying stomach juices. At first it helped fix stomach ulcers in rats then it helped with liver problems that were caused by drinking and it even helped with nerve damage all in the same animals.
In settings it is being looked at for inflammatory bowel disease and tendonitis.. People also like to use it off-label to help heal injuries, especially for tendons and ligaments.

The dosing for BPC-157 is 250-500 micrograms subcutaneously 1-2 times a day. If you are really hurt you can do 500-1000 micrograms, 2-3 times a day. You do this for 4-12 weeks.
The side effects are not that bad. You might get a headache. There is a risk of tumors but there isnt proof.

TB-500, also known as Thymosin Beta-4

works by binding to G-actin, which helps cells move around and create blood vessels and it also reduces inflammation. When you cut yourself TB-4 helps fix the cut.
In settings it is being looked at for wound care and heart repair, used to help muscles, tendons and ligaments recover, start with a dose of 5-10 milligrams subcutaneously or intramuscularly twice a week for 4-6 weeks. Then you reduce the dose to 2-5 milligrams, twice a week for maintenance.

The side effects arent usually a problem, Sometimes you might feel tired or get a headache.


Insulin Resistance | HGH, MK-677, Tesamorelin | Berberine 500 mg with carbs (max 1500 mg/day), or Metformin 500-1000 mg/day | Fasting glucose, HbA1c,
Chromium picolinate 200-400 mcg/day, R-ALA 300-600 mg/day
Water Retention | HGH, Test (E2), Tren | More potassium (avocados, KCl), dandelion root 500-1000 mg, furosemide and/or telmisartan 20-40 mg | Blood pressure, daily weight
High Prolactin | Tren, Deca, hexarelin | P-5-P 100-200 mg/day or Cabergoline 0.25 mg twice a week (Rx) | Serum prolactin (<15 ng/mL)
Hematocrit Up | Testosterone, Tren | Donate blood if Hct over 52%, stay hydrated, aspirin 81 mg if Hct over 54% | CBC every 3 months
GI Upset | GLP-1 agonists | 500-1000 mg ginger root, split your weekly dose into two shots
Low HDL | AAS (esp. Tren), GH | Citrus Bergamot 500-1000 mg, Omega-3 4 g daily | Lipid panel, ApoB
Blood Pressure Rising | Fluid retention, AAS | Telmisartan 20-80 mg/day, add amlodipine 5-10 mg if needed | Home BP (goal under 130/80)
Gyn0 | Aromatizing AAS, HCG | Anastrozole 0.25-0.5 mg every three days, Tamoxifen 10-20 mg daily | Serum E2, clinical check, Raloxifene 60 mg/day (for existing gyn0 reduction)
HPTA Suppression | All AAS, especially 19-nors | PCT: HCG 1000-2000 IU EOD ×3 weeks → Clomid 50 mg + Tamoxifene 20 mg ×4 weeks | LH, FSH, total T (check 4 weeks after PCT)
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Mirin the effort. Any thoughts on masterone propionate?
 

greysell

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