WHAT'S SCLEROSTIN INHIBITION?
Sclerostin inhibition refers to the process of blocking the activity of sclerostin, a protein that negatively regulates bone formation by inhibiting the Wnt signaling pathway. This inhibition can promote bone growth and is being explored as a potential treatment for conditions like osteoporosis and bone metastases in cancer patients.
In summary, It's the process of blocking the activity of sclerostin, Which is a protein that fucks your bone formation up. If you block it, It can promote bone growth.
THE METHOD:
MONOCLONAL ANTIBODIES - This binds to sclerostin, Neutralizing it. When bound, sclerostin can’t inhibit the Wnt receptor (LRP5/6), allowing osteoblasts to keep forming bone.
BEST EXAMLE OF A MONOCLONAL ANTIBODY: Romosozumab
There are plenty of other antibodies, Yet they are still experimental / Not yet on the market. Romosozumab is FDA approved aswell.
Other monoclonal antibodies that aren't yet on the market:
Blosozumab & Setrusumab
Sclerostin inhibition refers to the process of blocking the activity of sclerostin, a protein that negatively regulates bone formation by inhibiting the Wnt signaling pathway. This inhibition can promote bone growth and is being explored as a potential treatment for conditions like osteoporosis and bone metastases in cancer patients.
In summary, It's the process of blocking the activity of sclerostin, Which is a protein that fucks your bone formation up. If you block it, It can promote bone growth.
THE METHOD:
MONOCLONAL ANTIBODIES - This binds to sclerostin, Neutralizing it. When bound, sclerostin can’t inhibit the Wnt receptor (LRP5/6), allowing osteoblasts to keep forming bone.
BEST EXAMLE OF A MONOCLONAL ANTIBODY: Romosozumab
There are plenty of other antibodies, Yet they are still experimental / Not yet on the market. Romosozumab is FDA approved aswell.
Other monoclonal antibodies that aren't yet on the market:
Blosozumab & Setrusumab
