Guide Mechanisms behind bonesmashing proving its validity (NOT WATER) (3 Viewers)

[gandeism]

Mechanisms which will be included:

1. Mechanosensing and mechanotransduction
2. Actomyosin cytoskeleton response
3. FAK activation

We'll start going over what these mechanisms actually are and how bonesmashing activates them in order to remodel bone.

Mechanosensing and mechanotransduction

Mechanosensing is the initial detection of physical forces by bone cells, including osteoblasts. Mechanotransduction is the process that converts these mechanical stimuli into biochemical signals inside the cell.

So you're probably wondering what these biochemical signals will do in aiding bone growth... Well, they upregulate key osteogenic transcription factors.

Pathways increase the activity of Runx2 and Osterix (Sp7), which regulate bone formation and osteoblast differentiation. Upregulation in factors like Runx2 and Osterix (Sp7) promotes bone matrix production and mineralization.

Why does that happen? Well, Runx2 upregulates genes like FGFR2 and FGFR3, which increase progenitor cells that Osterix will then mature. (The cycle is so well put together it makes me cum.)

Let's summarise ts: Runx2 makes small progenitor cells and Osterix matures them (ts is for the iqlets who will reply with dnr).

Key mechanosensing pathways in osteoblasts​

These pathways are directly triggered or amplified by mechanical force and contribute to the anabolic (bone-building) side of remodeling:

Ion channels and calcium signaling: Mechanosensitive channels like Piezo1 open in response to shear stress or tension, causing rapid Ca²⁺ influx. This activates downstream effectors such as calmodulin, mTOR, calcineurin/NFATc1, and YAP1, leading to increased osteoprotegerin (OPG) production (which inhibits osteoclasts) and osteoblast activity.

-Downstream effectors are the genes, proteins, or molecules whose expression or activity is directly or indirectly regulated/activated by an upstream factor (in this case, calmodulin, mTOR, calcineurin/NFATc1, and YAP1).
In short the Calcium ion influx increases osteoblast activity and decreases osteoclast activity

Wnt/β-catenin pathway: Mechanical strain or fluid flow stabilizes β-catenin, which translocates to the nucleus and upregulates genes for bone matrix proteins (e.g., collagen I) and osteoblast proliferation/differentiation. This is a key anabolic signal in Wolff’s law adaptation.

β-catenin: dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription

Thats it for mechanosensing and mechanotransduction, There is a lot more to uncover but its tooo machh :(
Actomyosin cytoskeleton response

The actomyosin cytoskeleton is the contractile network inside the cell formed by actin filaments (F-actin) and myosin II motor proteins. It provides structural support, generates intracellular tension (contractility), and plays a central role in mechanotransduction in osteoblasts. (yep, we are back to mechanotransduction)

What it is and how it responds to mechanical force:​

Actin filaments polymerize and bundle into stress fibers.
Myosin II binds to these filaments and uses ATP to generate pulling force, creating prestress (internal tension) in the cell.
Under mechanical loading (strain, fluid shear stress, or impact), the actomyosin network reorganizes: actin filaments align parallel to the direction of force, become thicker/more stable, and increase overall contractility.
Polymerises is the third-person singular present tense verb for the chemical process where small molecules, called monomers, react together to form long, chain-like, or three-dimensional networks known as polymers.
Osteocytes convert mechanical signals into biochemical signals:

Release signaling molecules (e.g., prostaglandins, nitric oxide)
Modulate pathways like Wnt/β-catenin signaling

All those factors result in the activation of osteoblast cells and the down regulation in the activation of osteoclasts

FAK activation (Focal Adhesion Kinase)
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival

How its applied to bonesmashing
FAK acts as a signaling hub controlling:

Cell behavior​

Cell adhesion and spreading
Migration (important in wound healing, cancer)

Survival and growth​

Activates pathways like: PI3K/Akt, MAPK/ERK

Mechanotransduction​

Converts mechanical force → biochemical signals

(It all comes down to mechanotransduction)

Thats it for todays guide, If you want me to elaborate or expand this topic to its full extent make sure to ask me.

Credits to pubmed for giving me a 100% of the information i needed, and for grok.ai improving my grammar

Incel credits go to: EqBeliever and birthdefect for investing in me

 

[gandeism]

Circadex sensitive sapphire I apologise for my previous jester thread it was for good purposes

 

[⠀ ⠀ ⠀ ⠀ ⠀⠀ ⠀ ⠀ ⠀ ⠀⠀ ⠀ ⠀ ⠀]

dnr dnr dnr dnr

 

[sensitive sapphire]

Circadex will you take this or should i?(im still mad at you, fuck u)

 

[gandeism]

Circadex will you take this or should i?(im still mad at you, fuck u)

what??

 

[⠀ ⠀ ⠀ ⠀ ⠀⠀ ⠀ ⠀ ⠀ ⠀⠀ ⠀ ⠀ ⠀]

short ver:
mechanisms

1. Mechanosensing → signals → activates Runx2 & Osterix → bone growth
2. Actomyosin → adapts to force → boosts osteoblasts
3. FAK → converts force → growth signals

core: mechanical force → mechanotransduction → bone formation

 

[gandeism]

short ver:
mechanisms

1. Mechanosensing → signals → activates Runx2 & Osterix → bone growth
2. Actomyosin → adapts to force → boosts osteoblasts
3. FAK → converts force → growth signals

core: mechanical force → mechanotransduction → bone formation

It would be growth signals after runx2 and osterix. But you must mention the difference between those 2 factors because osterix primarily without runx2 wont result in growth

 

[EqBeliever]

Mechanisms which will be included:

1. Mechanosensing and mechanotransduction
2. Actomyosin cytoskeleton response
3. FAK activation

We'll start going over what these mechanisms actually are and how bonesmashing activates them in order to remodel bone.

Mechanosensing and mechanotransduction

Mechanosensing is the initial detection of physical forces by bone cells, including osteoblasts. Mechanotransduction is the process that converts these mechanical stimuli into biochemical signals inside the cell.

So you're probably wondering what these biochemical signals will do in aiding bone growth... Well, they upregulate key osteogenic transcription factors.

Pathways increase the activity of Runx2 and Osterix (Sp7), which regulate bone formation and osteoblast differentiation. Upregulation in factors like Runx2 and Osterix (Sp7) promotes bone matrix production and mineralization.

Why does that happen? Well, Runx2 upregulates genes like FGFR2 and FGFR3, which increase progenitor cells that Osterix will then mature. (The cycle is so well put together it makes me cum.)

Let's summarise ts: Runx2 makes small progenitor cells and Osterix matures them (ts is for the iqlets who will reply with dnr).

Key mechanosensing pathways in osteoblasts​

These pathways are directly triggered or amplified by mechanical force and contribute to the anabolic (bone-building) side of remodeling:

Ion channels and calcium signaling: Mechanosensitive channels like Piezo1 open in response to shear stress or tension, causing rapid Ca²⁺ influx. This activates downstream effectors such as calmodulin, mTOR, calcineurin/NFATc1, and YAP1, leading to increased osteoprotegerin (OPG) production (which inhibits osteoclasts) and osteoblast activity.

View attachment 41181

-Downstream effectors are the genes, proteins, or molecules whose expression or activity is directly or indirectly regulated/activated by an upstream factor (in this case, calmodulin, mTOR, calcineurin/NFATc1, and YAP1).
In short the Calcium ion influx increases osteoblast activity and decreases osteoclast activity

Wnt/β-catenin pathway: Mechanical strain or fluid flow stabilizes β-catenin, which translocates to the nucleus and upregulates genes for bone matrix proteins (e.g., collagen I) and osteoblast proliferation/differentiation. This is a key anabolic signal in Wolff’s law adaptation.

β-catenin: dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription
View attachment 41182

Thats it for mechanosensing and mechanotransduction, There is a lot more to uncover but its tooo machh :(
Actomyosin cytoskeleton response

The actomyosin cytoskeleton is the contractile network inside the cell formed by actin filaments (F-actin) and myosin II motor proteins. It provides structural support, generates intracellular tension (contractility), and plays a central role in mechanotransduction in osteoblasts. (yep, we are back to mechanotransduction)

What it is and how it responds to mechanical force:​

Actin filaments polymerize and bundle into stress fibers.
Myosin II binds to these filaments and uses ATP to generate pulling force, creating prestress (internal tension) in the cell.
Under mechanical loading (strain, fluid shear stress, or impact), the actomyosin network reorganizes: actin filaments align parallel to the direction of force, become thicker/more stable, and increase overall contractility.
Polymerises is the third-person singular present tense verb for the chemical process where small molecules, called monomers, react together to form long, chain-like, or three-dimensional networks known as polymers.
Osteocytes convert mechanical signals into biochemical signals:

Release signaling molecules (e.g., prostaglandins, nitric oxide)
Modulate pathways like Wnt/β-catenin signaling

All those factors result in the activation of osteoblast cells and the down regulation in the activation of osteoclasts

FAK activation (Focal Adhesion Kinase)
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival
View attachment 41186
How its applied to bonesmashing
FAK acts as a signaling hub controlling:

Cell behavior​

Cell adhesion and spreading
Migration (important in wound healing, cancer)

Survival and growth​

Activates pathways like: PI3K/Akt, MAPK/ERK

Mechanotransduction​

Converts mechanical force → biochemical signals

(It all comes down to mechanotransduction)

Thats it for todays guide, If you want me to elaborate or expand this topic to its full extent make sure to ask me.

Credits to pubmed for giving me a 100% of the information i needed, and for grok.ai improving my grammar

Incel credits go to: EqBeliever and birthdefect for investing in me

Glad that i have an high iq friends it was obvious that the first post was retardbait

 

[Tabula Rasa]

Mechanisms which will be included:

1. Mechanosensing and mechanotransduction
2. Actomyosin cytoskeleton response
3. FAK activation

We'll start going over what these mechanisms actually are and how bonesmashing activates them in order to remodel bone.

Mechanosensing and mechanotransduction

Mechanosensing is the initial detection of physical forces by bone cells, including osteoblasts. Mechanotransduction is the process that converts these mechanical stimuli into biochemical signals inside the cell.

So you're probably wondering what these biochemical signals will do in aiding bone growth... Well, they upregulate key osteogenic transcription factors.

Pathways increase the activity of Runx2 and Osterix (Sp7), which regulate bone formation and osteoblast differentiation. Upregulation in factors like Runx2 and Osterix (Sp7) promotes bone matrix production and mineralization.

Why does that happen? Well, Runx2 upregulates genes like FGFR2 and FGFR3, which increase progenitor cells that Osterix will then mature. (The cycle is so well put together it makes me cum.)

Let's summarise ts: Runx2 makes small progenitor cells and Osterix matures them (ts is for the iqlets who will reply with dnr).

Key mechanosensing pathways in osteoblasts​

These pathways are directly triggered or amplified by mechanical force and contribute to the anabolic (bone-building) side of remodeling:

Ion channels and calcium signaling: Mechanosensitive channels like Piezo1 open in response to shear stress or tension, causing rapid Ca²⁺ influx. This activates downstream effectors such as calmodulin, mTOR, calcineurin/NFATc1, and YAP1, leading to increased osteoprotegerin (OPG) production (which inhibits osteoclasts) and osteoblast activity.

View attachment 41181

-Downstream effectors are the genes, proteins, or molecules whose expression or activity is directly or indirectly regulated/activated by an upstream factor (in this case, calmodulin, mTOR, calcineurin/NFATc1, and YAP1).
In short the Calcium ion influx increases osteoblast activity and decreases osteoclast activity

Wnt/β-catenin pathway: Mechanical strain or fluid flow stabilizes β-catenin, which translocates to the nucleus and upregulates genes for bone matrix proteins (e.g., collagen I) and osteoblast proliferation/differentiation. This is a key anabolic signal in Wolff’s law adaptation.

β-catenin: dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription
View attachment 41182

Thats it for mechanosensing and mechanotransduction, There is a lot more to uncover but its tooo machh :(
Actomyosin cytoskeleton response

The actomyosin cytoskeleton is the contractile network inside the cell formed by actin filaments (F-actin) and myosin II motor proteins. It provides structural support, generates intracellular tension (contractility), and plays a central role in mechanotransduction in osteoblasts. (yep, we are back to mechanotransduction)

What it is and how it responds to mechanical force:​

Actin filaments polymerize and bundle into stress fibers.
Myosin II binds to these filaments and uses ATP to generate pulling force, creating prestress (internal tension) in the cell.
Under mechanical loading (strain, fluid shear stress, or impact), the actomyosin network reorganizes: actin filaments align parallel to the direction of force, become thicker/more stable, and increase overall contractility.
Polymerises is the third-person singular present tense verb for the chemical process where small molecules, called monomers, react together to form long, chain-like, or three-dimensional networks known as polymers.
Osteocytes convert mechanical signals into biochemical signals:

Release signaling molecules (e.g., prostaglandins, nitric oxide)
Modulate pathways like Wnt/β-catenin signaling

All those factors result in the activation of osteoblast cells and the down regulation in the activation of osteoclasts

FAK activation (Focal Adhesion Kinase)
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival
View attachment 41186
How its applied to bonesmashing
FAK acts as a signaling hub controlling:

Cell behavior​

Cell adhesion and spreading
Migration (important in wound healing, cancer)

Survival and growth​

Activates pathways like: PI3K/Akt, MAPK/ERK

Mechanotransduction​

Converts mechanical force → biochemical signals

(It all comes down to mechanotransduction)

Thats it for todays guide, If you want me to elaborate or expand this topic to its full extent make sure to ask me.

Credits to pubmed for giving me a 100% of the information i needed, and for grok.ai improving my grammar

Incel credits go to: EqBeliever and birthdefect for investing in me

Good thread, but I think you haven't quite grasped a few things. I'd also appreciate your sources.

 

[gandeism]

Good thread, but I think you haven't quite grasped a few things. I'd also appreciate your sources.

Thank you for the review, as I said 100% of the information put into my thread is from pubmed. It may sound bad but they have done a lot of research on such subjects. Id love if you were to help me grasp what i havent yet to improve my thread and ill make sure to tag you.

 

[Dexter]

wont work tho in a practical sense with a hammer

 

[gandeism]

wont work tho in a practical sense with a hammer

I believe it rather would since its applying stress, signaling molecules, opening pathways.

 

[Dexter]

I believe it rather would since its applying stress, signaling molecules, opening pathways.

I'll get back to you later, im busy rn

 

[gandeism]

I'll get back to you later, im busy rn

Sure, sure. You dont have to really im not trying to rush you.

 

[Tabula Rasa]

Thank you for the review, as I said 100% of the information put into my thread is from pubmed. It may sound bad but they have done a lot of research on such subjects. Id love if you were to help me grasp what i havent yet to improve my thread and ill make sure to tag you.

Your description of the osteoblast-osteoclast balance is incorrect. These pathways do not inhibit osteoclasts, primarily because bone resorption is necessary for the release of growth factors in the bone remodeling process. These pathways increase osteoblasts independently of osteoclasts, resulting in a net anabolic effect. The rest is relatively correct but extremely simplified, you should elaborate on your points and cite the studies you're drawing from. For example, your explanation of the Wnt/β-catenin pathway isn't incorrect, but it's too simplistic, so much so that it misrepresents how it manifests itself.

https://looksmax.gg/threads/mechano...ng-full-science-breakdown-and-theories.25319/

In this thread i explain the whole Wnt/β-catenin pathway and axis.

Can you link me the studies tho?

 

[Certifedsubhuman]

Dnr not a single molecule was read and u prolly didn’t mention the occipital bone smashing technique for iq and frontal lobe bonesmashing for EQ

 

[MedSlayer]

Here we go again

 

[gandeism]

Your description of the osteoblast-osteoclast balance is incorrect. These pathways do not inhibit osteoclasts, primarily because bone resorption is necessary for the release of growth factors in the bone remodeling process. These pathways increase osteoblasts independently of osteoclasts, resulting in a net anabolic effect. The rest is relatively correct but extremely simplified, you should elaborate on your points and cite the studies you're drawing from. For example, your explanation of the Wnt/β-catenin pathway isn't incorrect, but it's too simplistic, so much so that it misrepresents how it manifests itself.

https://looksmax.gg/threads/mechano...ng-full-science-breakdown-and-theories.25319/

In this thread i explain the whole Wnt/β-catenin pathway and axis.

Can you link me the studies tho?

Thank you for your feedback. I'll look into the pathway inhibition of osteoclasts and if you are correct ill tag you and fix my mistake. Also i do understand i oversimplified not just the beta catenin pathway but most of the processes because it would take me way to long and many people would'nt understand. Ill look into your thread, and if you give me a few minutes ill give you all of the pubmed studies i used, Ill dm them to you. Thanks!

 

[gandeism]

Dnr not a single molecule was read and u prolly didn’t mention the occipital bone smashing technique for iq and frontal lobe bonesmashing for EQ

This was funny, thanks

 

[gandeism]

Here we go again

Make sure to not type dnr/dnrd/tldr and tell me what i said wrong! Thanks!

 

[paracelsus]

dnr

what do you recommend is optimal then smashing hard with a hammer or some light tapping bs

 

[gandeism]

dnr

what do you recommend is optimal then smashing hard with a hammer or some light tapping bs

A mixture of smashing with a dense object equally on both sides of the bone if there isnt a mono smashing point, then following it up by fast, mild repeated hits like from a massage gun or knuckles. That would equal to the most stress, and the most pathways opened. Make sure to put a wet cloth over the point of smashing to minimise the friction induced skin damage. Thanks!

 

[EqBeliever]

Dnr not a single molecule was read and u prolly didn’t mention the occipital bone smashing technique for iq and frontal lobe bonesmashing for EQ

Eq like EqBeliever?

 

[EqBeliever]

A mixture of smashing with a dense object equally on both sides of the bone if there isnt a mono smashing point, then following it up by fast, mild repeated hits like from a massage gun or knuckles. That would equal to the most stress, and the most pathways opened. Make sure to put a wet cloth over the point of smashing to minimise the friction induced skin damage. Thanks!

Credit me nigga

 

[gandeism]

Credit me nigga

U threadu jesam, al nisi invento masage gun method niggeru

 

[EqBeliever]

U threadu jesam, al nisi invento masage gun method niggeru

Jesam ja sam the starter of BS with massage gun i vibrator

 

[gandeism]

Jesam ja sam the starter of BS with massage gun i vibrator

vibrator u guzu za pelvis maxanje, REPAJ ME AAAAAH

 

[MedSlayer]

Pathways increase the activity of Runx2 and Osterix (Sp7), which regulate bone formation and osteoblast differentiation. Upregulation in factors like Runx2 and Osterix (Sp7) promotes bone matrix production and mineralization.

30 seconds in and i already see 2 problems
1. Those pathways respond to mechanical loading not random blunt trauma or hitting it over time
2. Those pathways mostly make bones more dense any expansion in bone volume via those pathways are too small to make a visible difference
Will problably dnr the rest

 

[gandeism]

30 seconds in and i already see 2 problems
1. Those pathways respond to mechanical loading not random blunt trauma or hitting it over time
2. Those pathways mostly make bones more dense any expansion in bone volume via those pathways are too small to make a visible difference
Will problably dnr the rest

Mechanical loading, the definition:
Mechanical loading is
the physical stress, forces (such as gravity or muscle contraction), and strain applied to biological tissues (bone, muscle, tendon) or mechanical structures during activity

2. Is just BS, how can cellular mitosis make the bone only denser

 

[Tabula Rasa]

1. Those pathways respond to mechanical loading not random blunt trauma or hitting it over time

I want to know your reasoning behind how you've managed to separate these two things as something exclusive.

2. Those pathways mostly make bones more dense any expansion in bone volume via those pathways are too small to make a visible difference
Will problably dnr the rest

????

 

[gandeism]

I want to know your reasoning behind how you've managed to separate these two things as something exclusive.

????

Finding any BS just to avoid bonesmashing, copemaxx until we die ig JFL

 

[MedSlayer]

Mechanical loading, the definition:
Mechanical loading is
the physical stress, forces (such as gravity or muscle contraction), and strain applied to biological tissues (bone, muscle, tendon) or mechanical structures during activity

2. Is just BS, how can cellular mitosis make the bone only denser

1.Technically yes but its so hard to stimulate bones this way most people who bonesmash either dont use enough force for it to be considered a stimulus or their body interpret it as an injury thus giving the inflammation
2.Wont go too much in detail but basically when cellular mitosis happens your body prefer to increase bone density rather than expanding thus making expansion minimal and not visible

 

[gandeism]

1.Technically yes but its so hard to stimulate bones this way most people who bonesmash either dont use enough force for it to be considered a stimulus or their body interpret it as an injury thus giving the inflammation
2.Wont go too much in detail but basically when cellular mitosis happens your body prefer to increase bone density rather than expanding thus making expansion minimal and not visible

1. Thats your anecdote idgaf
2. Your body does not have such mechanism, it only regulates the mitosis

 

[EqBeliever]

vibrator u guzu za pelvis maxanje, REPAJ ME AAAAAH

will it improve my missaligned pelvis?????

 

[MedSlayer]

1. Thats your anecdote idgaf
2. Your body does not have such mechanism, it only regulates the mitosis

1.Not anecdote look throught the forums everybody who bonesmashed either saw no difference(no stimulus) or they just got inflammation (still doesnt stimulate those pathways)
2. 1.Genetic blueprint
2.Mechanical effiency
3.Energy cost

 

[EqBeliever]

wont work tho in a practical sense with a hammer

then massage gun walks in

 

[gandeism]

1.Not anecdote look throught the forums everybody who bonesmashed either saw no difference(no stimulus) or they just got inflammation (still doesnt stimulate those pathways)
2. 1.Genetic blueprint
2.Mechanical effiency
3.Energy cost

1. now i have your anecdote and the anecdote of the forum members which i do not know if they exist cause you could have made them up

2.thats litteraly just the regulation of cells

 

[MedSlayer]

1. now i have your anecdote and the anecdote of the forum members which i do not know if they exist cause you could have made them up

2.thats litteraly just the regulation of cells

1.

2.Exactly and those cells prefer to improve bone density rather than expansion

 

[gandeism]

1.

2.Exactly and those cells prefer to improve bone density rather than expansion

Did nigga just personify a cell

 

[Circadex]

Mechanisms which will be included:

1. Mechanosensing and mechanotransduction
2. Actomyosin cytoskeleton response
3. FAK activation

We'll start going over what these mechanisms actually are and how bonesmashing activates them in order to remodel bone.

Mechanosensing and mechanotransduction

Mechanosensing is the initial detection of physical forces by bone cells, including osteoblasts. Mechanotransduction is the process that converts these mechanical stimuli into biochemical signals inside the cell.

So you're probably wondering what these biochemical signals will do in aiding bone growth... Well, they upregulate key osteogenic transcription factors.

Pathways increase the activity of Runx2 and Osterix (Sp7), which regulate bone formation and osteoblast differentiation. Upregulation in factors like Runx2 and Osterix (Sp7) promotes bone matrix production and mineralization.

Why does that happen? Well, Runx2 upregulates genes like FGFR2 and FGFR3, which increase progenitor cells that Osterix will then mature. (The cycle is so well put together it makes me cum.)

Let's summarise ts: Runx2 makes small progenitor cells and Osterix matures them (ts is for the iqlets who will reply with dnr).

Key mechanosensing pathways in osteoblasts​

These pathways are directly triggered or amplified by mechanical force and contribute to the anabolic (bone-building) side of remodeling:

Ion channels and calcium signaling: Mechanosensitive channels like Piezo1 open in response to shear stress or tension, causing rapid Ca²⁺ influx. This activates downstream effectors such as calmodulin, mTOR, calcineurin/NFATc1, and YAP1, leading to increased osteoprotegerin (OPG) production (which inhibits osteoclasts) and osteoblast activity.

View attachment 41181

-Downstream effectors are the genes, proteins, or molecules whose expression or activity is directly or indirectly regulated/activated by an upstream factor (in this case, calmodulin, mTOR, calcineurin/NFATc1, and YAP1).
In short the Calcium ion influx increases osteoblast activity and decreases osteoclast activity

Wnt/β-catenin pathway: Mechanical strain or fluid flow stabilizes β-catenin, which translocates to the nucleus and upregulates genes for bone matrix proteins (e.g., collagen I) and osteoblast proliferation/differentiation. This is a key anabolic signal in Wolff’s law adaptation.

β-catenin: dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription
View attachment 41182

Thats it for mechanosensing and mechanotransduction, There is a lot more to uncover but its tooo machh :(
Actomyosin cytoskeleton response

The actomyosin cytoskeleton is the contractile network inside the cell formed by actin filaments (F-actin) and myosin II motor proteins. It provides structural support, generates intracellular tension (contractility), and plays a central role in mechanotransduction in osteoblasts. (yep, we are back to mechanotransduction)

What it is and how it responds to mechanical force:​

Actin filaments polymerize and bundle into stress fibers.
Myosin II binds to these filaments and uses ATP to generate pulling force, creating prestress (internal tension) in the cell.
Under mechanical loading (strain, fluid shear stress, or impact), the actomyosin network reorganizes: actin filaments align parallel to the direction of force, become thicker/more stable, and increase overall contractility.
Polymerises is the third-person singular present tense verb for the chemical process where small molecules, called monomers, react together to form long, chain-like, or three-dimensional networks known as polymers.
Osteocytes convert mechanical signals into biochemical signals:

Release signaling molecules (e.g., prostaglandins, nitric oxide)
Modulate pathways like Wnt/β-catenin signaling

All those factors result in the activation of osteoblast cells and the down regulation in the activation of osteoclasts

FAK activation (Focal Adhesion Kinase)
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival
View attachment 41186
How its applied to bonesmashing
FAK acts as a signaling hub controlling:

Cell behavior​

Cell adhesion and spreading
Migration (important in wound healing, cancer)

Survival and growth​

Activates pathways like: PI3K/Akt, MAPK/ERK

Mechanotransduction​

Converts mechanical force → biochemical signals

(It all comes down to mechanotransduction)

Thats it for todays guide, If you want me to elaborate or expand this topic to its full extent make sure to ask me.

Credits to pubmed for giving me a 100% of the information i needed, and for grok.ai improving my grammar

Incel credits go to: EqBeliever and birthdefect for investing in me

Just shut up about this bonesmashing cope it's ridiculous

it can't enhance your aesthetics, end of.

 

[gandeism]

Just shut up about this bonesmashing cope it's ridiculous

it can't enhance your aesthetics, end of.

yes, it would be nice to shut up... THATS IF THE PROOF WASNT ON THE SIDE OF BONESMASHING. I truly appreciate normies like you denying it, it divides us from your kind.

 

[MedSlayer]

Did nigga just personify a cell

Ad homimen
Let me just finish my exams real quick i will rape your thread so bad

 

[Circadex]

yes, it would be nice to shut up... THATS IF THE PROOF WASNT ON THE SIDE OF BONESMASHING. I truly appreciate normies like you denying it, it divides us from your kind.

Enjoy your asymmetry inducing heterotopic ossification & CTE

 

[gandeism]

Enjoy your asymmetry inducing heterotopic ossification & CTE

first you overestimated bonesmashing by saying the gains will be so massive it will make you assymetrical then you do it again by saying CTE is guaranteed

 

[Tabula Rasa]

Enjoy your asymmetry

So it works for bone augmentation?

 

[gandeism]

Ad homimen
Let me just finish my exams real quick i will rape your thread so bad

Sure sure, let chatgpt cook me up then ill fold your ass

 

[Circadex]

first you overestimated bonesmashing by saying the gains will be so massive it will make you assymetrical then you do it again by saying CTE is guaranteed

So it works for bone augmentation?

What the fuck are you talking about? Are you both retarded?

do you know what I'm talking about

 

[gandeism]

What the fuck are you talking about? Are you both retarded?

do you know what I'm talking about

YOU must not know what you said, make a point

 

[MedSlayer]

Sure sure, let chatgpt cook me up then ill fold your ass

Just prove your a low iq monkey i say one type of sophism and think muhhh chatgpt read some books and devellop your intellect instead of posting some ass threads and saying dumb shit like this

 

[gandeism]

Just prove your a low iq monkey i say one type of sophism and think muhhh chatgpt read some books and devellop your intellect instead of posting some ass threads and saying dumb shit like this

Reject what you dont like, would you believe in god if you saw him in front of you with your own 2 human eyes