[Recession]

The typical methods for reversing hair loss such as minoxidil do work but it can be harmful to you whether topical affecting irritation of the scalp or oral affecting cardiovascular health by lowering blood pressure

However there's a natural method not talked about enough and that is
Peppercorn

Peppercorn contains piperine which studies show can suppress adipogenesis (fat‑cell formation) in hair‑stem cells
Basically it inhibited the process by which hair‑stem cells differentiate into fat cells, via downregulating a transcription factor (PPARγ) involved in adipogenesis
https://link.springer.com/article/10.1186/s13765-024-00889-4

Now how to apply it

Take 2 tablespoons of black and white peppercorn and grind it till it becomes a powder

Then mix it with 90ml of rainwater which you have collected
Rainwater is preferred since it is pure and free of minerals, chlorine, and chemicals that might irritate the scalp
Now apply it to the scalp and wait 30 minutes before washing out

The pepper exfoliates the scalp which stimulates follicles
This process is similar to the process of micro needling

Possible irritation may occur so its best to do this every 3 days


Conclusion
Whilst minoxidil will probably work more effectively this is a great solution for anyone wanting to go down a natural route
However studies show that the effectiveness is not far off minoxidil revealing had a success rate of 63% in treatment of hair loss compared to minoxidil's success rate of 70%
https://pubmed.ncbi.nlm.nih.gov/35318791/
Therefore I do believe this method to be beneficial to many

 

[Finitumest]

The first study is mostly an asummption cause the findings of the piperine study are mechanistic, not clinical.

Researchers observed was that piperine:

-reduces lipid accumulation,
-influences PPARy(Peroxisome Proliferator-Activated Receptor Gamma) and
-supresses adipogénesis in vitro (meaning the supression of the process trough which cells become fat cells in test tubes,culturedcells, or other environments outside a living organism)

Reference: “In CD34/CD49f double-positive hair follicle bulge stem cells isolated from mouse vibrissae, piperine inhibited cellular adipogenesis … In human dermal papilla cells, piperine inhibited cellular adipogenesis, as shown by the reduction in ORO staining and the downregulation of PPARγ target genes.”

and then they make a theoretical connection between adipogenesis and hair biology: “Because adipogenesis is associated with the biology of hair follicles, altering adipogenesis may influence hair conditions.”

The ("may influence") tells that connection is speculative and most important altering adipogenesis in isolated cells does not automatically mean:

-hair growth
-hair grows less or any change will occur in a living human scalp. So basically a molecular effect does not equal a clinical effect.

Also rain water is a big no like it contains pollutants, enviromental chemicals... Not really sure

and this:“Effectiveness is not far off minoxidil revealing a success rate of 63% in treatment of hair loss compared to minoxidil's success rate of 70%.” its not a good statement cause in: https://pubmed.ncbi.nlm.nih.gov/35318791/

not only uses pipperine but capsaicin and curcumin so the study actually focuses on alopecia areata, an autoimmune condition. Minoxidl is usually tested for androgenic alopecia(pattern hair loss) these are very different

types of hair loss with different mechanisms so the 63% succes rate in alopecia areata does not mean the same to pattern baldness.

The minoxidil comparision is misleading cause in the study, minoxidil's 70% vs the mixture's 63% cannot be extrapolated to plain pepper. This could lead to the effect being mostly because of capsaicin or curcumin idk honestly..

So there is

No clinical evidence for topical pepper/piperine alone

There is no trial showing peppercorn powder or isolated piperine applied to the scalp achieves any measurable hair regrowth.

Therefore,stating that “pepper is almost as effective as minoxidil” is unsupported and speculative.


Correct me if im wrong.