dignity435
Iron
- Joined
- Jul 15, 2026
- Posts
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*This is my first post, please bear with me
Intro:
If you're like me and have been diagnosed with IBD, you understand that when you are actively inflamed, your health indicators are horrible. My IBD manifested into acne, funky-looking hair, and weight loss. Thankfully, I managed to overcome this thru a variety of methods (140 lbs to 165; clear skin and hair; and most importantly, 0 IBD SYMPTOMS!!) --> which I will share with you all in another thread.
Intestinal inflammation in those diagnosed with IBD and otherwise are at an increased risk of CAC --> Colitis-Associated-Cancer. With IBD diagnosis rates increasing steadily due to myriad factors, like environmental pollution, microplastics, seed oils, poor lifestyles, etc., we can certainly expect an increase in colorectal cancer diagnosis rates to follow.
"Among patients with ulcerative colitis, the risk of colon cancer has been found to be as high as 2% at 10 years, 8% at 20 years, and 18% at 30 years after initial diagnosis."
The development of CAC in patients suffering from IBD is a strong example of an association between (1) intestinal inflammation and (2) carcinogenesis.
OUR GOAL IS TO MINIMIZE THE FORMER AND THE LATTER!
Now, if you have IBD or are at risk of colon cancer, it is NOT over. I promise. I will break down a fascinating study:
Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-Inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model
Part 1: Understanding the processes
To understand the study, you must grasp a few key ideas:
The human digestive tract holds "hPepT1" --> a 'delivery system' specialized protein that works to absorb nutrition from your digestive tract and into your bloodstream.
Here's where it gets interesting:
hPepT1 EXPRESSION in intestinal epithelial cells (the cells that protect organs) is positively associated with inflammatory bowel disease. Specifically, colon tumor samples exhibited increased 'staining' relative to both normal and benign tissues. This suggests that the upregulation of PepT1 can, and probably should, be targeted as a treatment for CAC.
How?
KPV!
E.g.: Overexpression of hPept1 during IBD; low levels of expression in a healthy colon
Now, what this study set out to accomplish was to induce CAC in mice via inflammatory means, measure the relationship between tumor growth/size and PepT1 levels, and then discover how KPV impacts these measures
PART 2: FINDINGS
(1) Tumor Growth is Increased in Mice that Overexpress PepT1 in Intestinal Epithelial Cells
(2) Overexpression of hPepT1 Deregulates Proliferation and Apoptosis (programmed cell death)
*****(3) KPV Prevents Intestinal Inflammation and Tumorigenesis During Colitis-Associated Carcinogenesis in a PepT1-Dependent Manner*****
Recall: CAC is caused by INFLAMMATION and CARCINOGENESIS
**If KPV minimizes both, then logically, CAC risk must be minimized as well.
CRUCIAL CAVEAT for GENETICALLY caused colorectal cancer:
Mice with cancer caused by genetic means were given KPV:
(1) Inflammation did indeed decrease; but
(2) There was no change in tumor growth/size
This suggests that colon cancer caused by genetics can not inherently be prevented by KPV. But the study noted that 'genetic colon carcinoma models only represent 2-5% of all colon cancers.' Statistically, this means that the risk of colon cancer caused by genetics is pretty low (for the common person...)
I suggest that if you are at risk of genetic colon cancer, you should microdose aspirin; however, if you have IBD, please be cautious, as it is known to cause stomach bleeding. Personally, I am doing a bit of research on Ray Peat's opinion on aspirin and stomach bleeding before I take any pill.
Also, get regular colonoscopies. This is easily the single greatest means to prevent and treat any benign polyps or tumors before they spread and eventually kill you. Don't ruin your life because of ignorance.
Also, I suggest taking a genetic test to see if you have Lynch Syndrome or some inherent risk of colon cancer. If you are not at any risk, there is no need to take aspirin for the purpose of cancer risk reduction.
I will be taking my genetic test in the next month or two.
Thoughts? Opinions? Any other Peptides I should research for inflammation and/or cancer? Thanks for reading.
Intro:
If you're like me and have been diagnosed with IBD, you understand that when you are actively inflamed, your health indicators are horrible. My IBD manifested into acne, funky-looking hair, and weight loss. Thankfully, I managed to overcome this thru a variety of methods (140 lbs to 165; clear skin and hair; and most importantly, 0 IBD SYMPTOMS!!) --> which I will share with you all in another thread.
Intestinal inflammation in those diagnosed with IBD and otherwise are at an increased risk of CAC --> Colitis-Associated-Cancer. With IBD diagnosis rates increasing steadily due to myriad factors, like environmental pollution, microplastics, seed oils, poor lifestyles, etc., we can certainly expect an increase in colorectal cancer diagnosis rates to follow.
"Among patients with ulcerative colitis, the risk of colon cancer has been found to be as high as 2% at 10 years, 8% at 20 years, and 18% at 30 years after initial diagnosis."
The development of CAC in patients suffering from IBD is a strong example of an association between (1) intestinal inflammation and (2) carcinogenesis.
OUR GOAL IS TO MINIMIZE THE FORMER AND THE LATTER!
Now, if you have IBD or are at risk of colon cancer, it is NOT over. I promise. I will break down a fascinating study:
Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-Inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model
Part 1: Understanding the processes
To understand the study, you must grasp a few key ideas:
The human digestive tract holds "hPepT1" --> a 'delivery system' specialized protein that works to absorb nutrition from your digestive tract and into your bloodstream.
Here's where it gets interesting:
hPepT1 EXPRESSION in intestinal epithelial cells (the cells that protect organs) is positively associated with inflammatory bowel disease. Specifically, colon tumor samples exhibited increased 'staining' relative to both normal and benign tissues. This suggests that the upregulation of PepT1 can, and probably should, be targeted as a treatment for CAC.
How?
KPV!
E.g.: Overexpression of hPept1 during IBD; low levels of expression in a healthy colon
Now, what this study set out to accomplish was to induce CAC in mice via inflammatory means, measure the relationship between tumor growth/size and PepT1 levels, and then discover how KPV impacts these measures
PART 2: FINDINGS
(1) Tumor Growth is Increased in Mice that Overexpress PepT1 in Intestinal Epithelial Cells
(2) Overexpression of hPepT1 Deregulates Proliferation and Apoptosis (programmed cell death)
*****(3) KPV Prevents Intestinal Inflammation and Tumorigenesis During Colitis-Associated Carcinogenesis in a PepT1-Dependent Manner*****
Recall: CAC is caused by INFLAMMATION and CARCINOGENESIS
**If KPV minimizes both, then logically, CAC risk must be minimized as well.
CRUCIAL CAVEAT for GENETICALLY caused colorectal cancer:
Mice with cancer caused by genetic means were given KPV:
(1) Inflammation did indeed decrease; but
(2) There was no change in tumor growth/size
This suggests that colon cancer caused by genetics can not inherently be prevented by KPV. But the study noted that 'genetic colon carcinoma models only represent 2-5% of all colon cancers.' Statistically, this means that the risk of colon cancer caused by genetics is pretty low (for the common person...)
I suggest that if you are at risk of genetic colon cancer, you should microdose aspirin; however, if you have IBD, please be cautious, as it is known to cause stomach bleeding. Personally, I am doing a bit of research on Ray Peat's opinion on aspirin and stomach bleeding before I take any pill.
Also, get regular colonoscopies. This is easily the single greatest means to prevent and treat any benign polyps or tumors before they spread and eventually kill you. Don't ruin your life because of ignorance.
Also, I suggest taking a genetic test to see if you have Lynch Syndrome or some inherent risk of colon cancer. If you are not at any risk, there is no need to take aspirin for the purpose of cancer risk reduction.
I will be taking my genetic test in the next month or two.
Thoughts? Opinions? Any other Peptides I should research for inflammation and/or cancer? Thanks for reading.
