Serious importance of blocking the mineralocorticoid receptor when using certain roids - MUST READ (1 Viewer)

[atrophicpyra]

so certain roids have anticatabolic effects through altered cortisol signaling indirectly via gene expression
however glucucorticoid isnt the only receptor cortisol goes in it also goes into a receptor called the mineralocorticoid receptor which is highly expressed in kidneys and the brain and in other tissues
now there is an enzyme called 11β-HSD2 which converts cortisol into a weaker, cortisone in the kdineys, this is a protection mechanism that is in place to prevent the cortisol from reaching the receptor and breaking the electrolye ratio in ur body since mr has MUCH HIGHER receptor affinity to cortisol than regular gr
however what this means is that there is gonna be a high local concentration of cortisol in places where there is no 11β-HSD2 aka the brain which is pretty damaging increasing oxidative stress markers etc,
what can we do? well we can take direct MR blockers like Eplerenone to prevent high local concentrations of mr in the brain and other tissues without 11β-HSD2
btw this is ESSENTIAL if ur taking a glucucorticoid receptor antagonist like mifepristone (i have talked abt this in another thread) since there will be so little cortisol binding to the gr however there is still cortisol in the blood even getting upregulated by the adrenal glands due to receptor blockade which is gonna get accumulated in the mr in high concentrations.

Syna Dexter NorthAfricanRopemaxxer muissocool

 

[User123]

Not a single molecule understood

 

[atrophicpyra]

Not a single molecule understood

what do u not understand i lowk rushed this so it might not make sense

 

[FoidSlayer]

Every molecule understood

 

[SinisterTRADition]

I Didn’t read punk

 

[sensitive sapphire]

Half the molecules understood

 

[atrophicpyra]

Half the molecules understood

conclusion, take eplerenone when taking tren or anavar or any other gr antagonist roid

 

[muissocool]

Thanks for the tag

 

[sensitive sapphire]

conclusion, take eplerenone when taking tren or anavar or any other gr antagonist roid

It was a joke bro i didnt even read it

 

[atrophicpyra]

Thanks for the tag

np niggaaa

 

[atrophicpyra]

It was a joke bro i didnt even read it

read it nigger

 

[NorthAfricanRopemaxxer]

so certain roids have anticatabolic effects through altered cortisol signaling indirectly via gene expression
however glucucorticoid isnt the only receptor cortisol goes in it also goes into a receptor called the mineralocorticoid receptor which is highly expressed in kidneys and the brain and in other tissues
now there is an enzyme called 11β-HSD2 which converts cortisol into a weaker, cortisone in the kdineys, this is a protection mechanism that is in place to prevent the cortisol from reaching the receptor and breaking the electrolye ratio in ur body since mr has MUCH HIGHER receptor affinity to cortisol than regular gr
however what this means is that there is gonna be a high local concentration of cortisol in places where there is no 11β-HSD2 aka the brain which is pretty damaging increasing oxidative stress markers etc,
what can we do? well we can take direct MR blockers like Eplerenone to prevent high local concentrations of mr in the brain and other tissues without 11β-HSD2
btw this is ESSENTIAL if ur taking a glucucorticoid receptor antagonist like mifepristone (i have talked abt this in another thread) since there will be so little cortisol binding to the gr however there is still cortisol in the blood even getting upregulated by the adrenal glands due to receptor blockade which is gonna get accumulated in the mr in high concentrations.
View attachment 48983

Syna Dexter NorthAfricanRopemaxxer muissocool

Mirin brah quite a good explanation