GunnerW
JFL
- Joined
- Jan 15, 2026
- Posts
- 39
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- 41
First off we’re going to be talking about the two main reasons that really kill people running high doses of gear.
The first is LV Left Ventricular increase which mainly means the wall of the left ventricle gets thicker. This makes it harder for the heart to fill and pump blood efficiently. Heart cells have androgen receptors so when you have excess androgens they bind to the heart cells making them bigger while also promoting fibrosis which increases the chance of abnormal heart rhythms.
The second main reason is HDL being lowered and LDL climbing higher. We can see even at doses around 300 mg a week of testosterone HDL C fell about 21 percent which drastically lowers the amount of extra cholesterol being carried away from the arteries to the liver. When HDL drops more cholesterol can stay stuck in vessel walls and form plaque. Should I make a full thread with how to mitigate sides and cycle design?
The first is LV Left Ventricular increase which mainly means the wall of the left ventricle gets thicker. This makes it harder for the heart to fill and pump blood efficiently. Heart cells have androgen receptors so when you have excess androgens they bind to the heart cells making them bigger while also promoting fibrosis which increases the chance of abnormal heart rhythms.
The second main reason is HDL being lowered and LDL climbing higher. We can see even at doses around 300 mg a week of testosterone HDL C fell about 21 percent which drastically lowers the amount of extra cholesterol being carried away from the arteries to the liver. When HDL drops more cholesterol can stay stuck in vessel walls and form plaque. Should I make a full thread with how to mitigate sides and cycle design?

