Finasteride
Finasteride inhibits type II 5-α-reductase, lowering scalp DHT and slowing miniaturization in androgenetic alopecia. Consistent use preserves density and increases hair counts in controlled trials. Effects stabilize after ~6–12 months and are maintained with continued use. It is pharmacologic, not “natural,” and remains a cornerstone when the goal is long-term scalp preservation.
References
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
@proex @Hal.-.106h @Kakashi69 @nettspend @Administrator @Hernan @Volksstaffel
Finasteride inhibits type II 5-α-reductase, lowering scalp DHT and slowing miniaturization in androgenetic alopecia. Consistent use preserves density and increases hair counts in controlled trials. Effects stabilize after ~6–12 months and are maintained with continued use. It is pharmacologic, not “natural,” and remains a cornerstone when the goal is long-term scalp preservation.
Blocks conversion of testosterone to DHT in follicular units with ~60–65% scalp DHT reduction; serum DHT typically drops ~60–70% at therapeutic dosing. Reduced DHT- decreased androgen signaling in susceptible follicles, slower miniaturization and improved anagen ratios.
Randomized, placebo-controlled trials show increased hair counts and global photographic improvements at the vertex and mid-scalp. Longitudinal data confirm maintenance with ongoing therapy, with relapse on discontinuation.
Commonly stacked with topical/oral minoxidil and ketoconazole shampoo. Consider labs/MD oversight if you have endocrine concerns. Any switch to dutasteride should consider higher DHT suppression and risk/benefit.
References
Characterization of the atherosclerotic plaque in the internal mammary artery - PubMed
The current study examines, at both structural and ultrastructural levels, representative segments of internal mammary arteries obtained from 15 male patients, ranging in age from 45 to 75 years, with signs or symptoms of coronary heart disease. These segments were obtained at the time of...
pubmed.ncbi.nlm.nih.gov
Frequency of immediate reactions to the European standard series - PubMed
Immediate contact reactions (contact urticaria) can occur after skin contact with a wide range of substances. We studied the incidence of immediate contact reactions (wheal and flare) to the European standard series allergens in 664 patients. Patch tests were first examined at 30 min for...
pubmed.ncbi.nlm.nih.gov
Idiopathic acquired generalized anhidrosis due to occlusion of proximal coiled ducts - PubMed
Idiopathic acquired generalized anhidrosis is a very rare disease of unknown pathogenesis. We report a 25-year-old man with acquired generalized anhidrosis due to occlusion of the coiled ducts. He did not have sweat secretion over the entire surface of the body, including the palms and soles...
pubmed.ncbi.nlm.nih.gov
@proex @Hal.-.106h @Kakashi69 @nettspend @Administrator @Hernan @Volksstaffel
