[Biomaxx]

Alright. I’ll compress everything into one clean, copy-pasteable text, no files, no UI tricks, no fluff. This is the true state of the art as of ~2025, from boring reality to genuinely exotic pharma.
I’m going to be very explicit about what actually grows bone, what only preserves it, and what is speculative but real.

---

FIRST: A hard truth you need upfront​

There are three fundamentally different goals people confuse:

1. Increase bone mineral density / thickness (osteogenesis)
2. Regenerate or heal bone (injury, defects)
3. Increase bone length / stature (growth plates or distraction)

Only #1 and #2 are realistically achievable without surgery in adults.
#3 is basically impossible once growth plates are fused, outside of distraction osteogenesis.
Everything below is ranked by real anabolic power on bone.

---

TIER 0 — BIOLOGICAL LIMITS (NON-NEGOTIABLE)​

• Long bone lengthening requires open growth plates or surgery
• Adult bone growth = thicker, denser, stronger bone, not longer
• Bone responds to:
  • Mechanical strain
  • Wnt/β-catenin signaling
  • PTH signaling
  • Suppression of sclerostin
  • Adequate mineral + hormonal environment

If a method doesn’t touch one of those, it’s cosmetic noise.

---

TIER 1 — STRONGEST REAL-WORLD BONE-BUILDERS (CLINICAL, PROVEN)​

These are the most powerful non-surgical ways humans have ever grown bone.

---

1. Romosozumab (Anti-Sclerostin Antibody)​

This is the current king.

• Mechanism:
  • Neutralizes sclerostin (SOST) → releases the Wnt brake
  • Simultaneously:
    • ↑ osteoblast activity (bone formation)
    • ↓ osteoclast activity (bone resorption)
• Effect:
  • ~10–13% lumbar spine BMD increase in 12 months
  • Works faster than teriparatide
  • Creates a rare “anabolic window”
• Clinical reality:
  • Approved for osteoporosis
  • Monthly injections
  • Limited to ~12 months due to cardiovascular risk signal
• Important insight:
  • Humans with genetic SOST deficiency have massive bones, facial overgrowth, increased height

This is as close as medicine has gotten to “turning bone growth back on.”

---

2. Teriparatide (PTH 1-34) & Abaloparatide​

Second place, still extremely powerful

• Mechanism:
  • Pulsed PTH signaling → osteoblast activation > osteoclasts
• Effect:
  • 8–10% BMD increases
  • Improves microarchitecture
• Limitations:
  • Less effective in cortical bone than romosozumab
  • Lifetime use capped (~2 years)
• Note:
  • Continuous PTH = bone loss
  • Pulsed PTH = bone gain

These drugs literally re-teach adult bone to form new matrix.

---

TIER 2 — STRONG SUPPORTERS (REQUIRED FOR MAX RESULTS)​

These won’t build bone alone, but without them, Tier 1 underperforms.

---

Mechanical Loading (Non-Negotiable)​

Bone only grows where force demands it.

• High-impact, axial, or torsional load:
  • Squats
  • Deadlifts
  • Jumping
  • Loaded carries
• Mechanism:
  • Mechanical strain ↓ sclerostin locally
  • Activates osteocytes → Wnt signaling
• Key:
  • Swimming & cycling do almost nothing for bone

No force → no signal → no growth.

---

Calcium + Vitamin D (Baseline)​

• Calcium: ~700–1000 mg/day
• Vitamin D: ~1000 IU/day (more if deficient)
• Purpose:
  • Supplies raw material
  • Enables mineralization
• Important:
  • These do not grow bone alone
  • They only allow growth to occur

---

Hormonal Sufficiency​

• Testosterone (men)
• Estrogen (women AND men, in correct balance)
• Thyroid not excessive
• Cortisol not chronically elevated

Bone hates stress hormones and hypogonadism.

---

TIER 3 — NICHE / EMERGING PHARMA (REAL BUT EXPERIMENTAL)​

This is where things get interesting.

---

1. GPR133 (ADGRD1) Agonists — e.g. AP503 (Preclinical)​

• Mechanism:
  • Activates osteoblast-specific GPCR
  • Increases bone formation without suppressing resorption
• Animal data:
  • Increased bone mass
  • Improved strength
• Status:
  • Preclinical / early translational
• Why this matters:
  • First small-molecule osteoanabolic not hormone-based

If this translates to humans, it’s huge.

---

2. iSN40 (Oligodeoxynucleotide Bone Drug)​

• What it is:
  • Short synthetic DNA fragment
• Mechanism:
  • Directly promotes osteoblast differentiation
• Research:
  • Increased bone formation in models
• Significance:
  • Not hormonal
  • Not antibody-based
  • New drug class entirely

Early, but conceptually very strong.

---

3. MSC-Derived Exosomes (Cell-Free Regeneration)​

• What they are:
  • Vesicles secreted by mesenchymal stem cells
• Mechanism:
  • Deliver miRNA + growth signals
  • Promote osteogenesis & angiogenesis
• Used with:
  • Hydrogels
  • Scaffolds
• Status:
  • Animal models
  • Early human research

This is regenerative medicine, not supplementation.

---

4. Smart Scaffolds / 3D-Printed Bone Matrices​

• Used for:
  • Bone defects
  • Skull, jaw, orthopedic injuries
• Features:
  • Mimic native bone stiffness
  • Release growth factors
  • Guide cell differentiation
• Not for:
  • Systemic bone growth
• But:
  • Extremely powerful locally

---

TIER 4 — ELECTRICAL / ULTRASOUND STIMULATION (LIMITED)​

• Low-intensity pulsed ultrasound (LIPUS):
  • Mixed evidence
  • Minor acceleration of fracture healing
• Electrical stimulation:
  • Helps non-unions
  • Weak anabolic effect systemically

These are adjuncts, not growth drivers.

---

TIER 5 — WHAT DOES NOT WORK (IMPORTANT)​

• Supplements claiming “bone growth” (boron, silica, strontium):
  • Marginal at best
• GH alone:
  • Does NOT grow adult bones
• Collagen supplements:
  • Structural support only
• “Growth plate reopening” compounds:
  • Pure fiction

If it doesn’t touch Wnt / PTH / mechanical signaling, it’s cope.

---

THE ACTUAL NO.1 STRATEGY (REALITY)​

If you ask:
“What is the single strongest way humans can grow bone?”
The honest answer is:

Romosozumab + heavy mechanical loading + adequate minerals + proper hormones

Everything else is secondary or experimental.

---

FINAL SYNTHESIS (HIGH-LEVEL TAKEAWAY)​

• Adult humans can grow bone
• They cannot grow longer bones without surgery
• The bone growth switch is:
  • Sclerostin suppression
  • Wnt activation
  • Mechanical strain
• Modern medicine can now override evolutionary brakes
• The future is:
  • Small-molecule osteoanabolics
  • Exosome-based regeneration
  • Gene-level modulation of bone signaling

Bone is not dead tissue.
It’s conservative tissue — and we’re finally learning how to argue with it.
If you want, next we can:

• Rank these specifically for facial bones
• Talk growth plates vs periosteal expansion
• Or design a maximal bone-anabolic stack (theoretical) without crossing into fantasy

 

[Biomaxx]

Alright. I’ll compress everything into one clean, copy-pasteable text, no files, no UI tricks, no fluff. This is the true state of the art as of ~2025, from boring reality to genuinely exotic pharma.
I’m going to be very explicit about what actually grows bone, what only preserves it, and what is speculative but real.

---

FIRST: A hard truth you need upfront​

There are three fundamentally different goals people confuse:

1. Increase bone mineral density / thickness (osteogenesis)
2. Regenerate or heal bone (injury, defects)
3. Increase bone length / stature (growth plates or distraction)

Only #1 and #2 are realistically achievable without surgery in adults.
#3 is basically impossible once growth plates are fused, outside of distraction osteogenesis.
Everything below is ranked by real anabolic power on bone.

---

TIER 0 — BIOLOGICAL LIMITS (NON-NEGOTIABLE)​

• Long bone lengthening requires open growth plates or surgery
• Adult bone growth = thicker, denser, stronger bone, not longer
• Bone responds to:
  • Mechanical strain
  • Wnt/β-catenin signaling
  • PTH signaling
  • Suppression of sclerostin
  • Adequate mineral + hormonal environment

If a method doesn’t touch one of those, it’s cosmetic noise.

---

TIER 1 — STRONGEST REAL-WORLD BONE-BUILDERS (CLINICAL, PROVEN)​

These are the most powerful non-surgical ways humans have ever grown bone.

---

1. Romosozumab (Anti-Sclerostin Antibody)​

This is the current king.

• Mechanism:
  • Neutralizes sclerostin (SOST) → releases the Wnt brake
  • Simultaneously:
    • ↑ osteoblast activity (bone formation)
    • ↓ osteoclast activity (bone resorption)
• Effect:
  • ~10–13% lumbar spine BMD increase in 12 months
  • Works faster than teriparatide
  • Creates a rare “anabolic window”
• Clinical reality:
  • Approved for osteoporosis
  • Monthly injections
  • Limited to ~12 months due to cardiovascular risk signal
• Important insight:
  • Humans with genetic SOST deficiency have massive bones, facial overgrowth, increased height

This is as close as medicine has gotten to “turning bone growth back on.”

---

2. Teriparatide (PTH 1-34) & Abaloparatide​

Second place, still extremely powerful

• Mechanism:
  • Pulsed PTH signaling → osteoblast activation > osteoclasts
• Effect:
  • 8–10% BMD increases
  • Improves microarchitecture
• Limitations:
  • Less effective in cortical bone than romosozumab
  • Lifetime use capped (~2 years)
• Note:
  • Continuous PTH = bone loss
  • Pulsed PTH = bone gain

These drugs literally re-teach adult bone to form new matrix.

---

TIER 2 — STRONG SUPPORTERS (REQUIRED FOR MAX RESULTS)​

These won’t build bone alone, but without them, Tier 1 underperforms.

---

Mechanical Loading (Non-Negotiable)​

Bone only grows where force demands it.

• High-impact, axial, or torsional load:
  • Squats
  • Deadlifts
  • Jumping
  • Loaded carries
• Mechanism:
  • Mechanical strain ↓ sclerostin locally
  • Activates osteocytes → Wnt signaling
• Key:
  • Swimming & cycling do almost nothing for bone

No force → no signal → no growth.

---

Calcium + Vitamin D (Baseline)​

• Calcium: ~700–1000 mg/day
• Vitamin D: ~1000 IU/day (more if deficient)
• Purpose:
  • Supplies raw material
  • Enables mineralization
• Important:
  • These do not grow bone alone
  • They only allow growth to occur

---

Hormonal Sufficiency​

• Testosterone (men)
• Estrogen (women AND men, in correct balance)
• Thyroid not excessive
• Cortisol not chronically elevated

Bone hates stress hormones and hypogonadism.

---

TIER 3 — NICHE / EMERGING PHARMA (REAL BUT EXPERIMENTAL)​

This is where things get interesting.

---

1. GPR133 (ADGRD1) Agonists — e.g. AP503 (Preclinical)​

• Mechanism:
  • Activates osteoblast-specific GPCR
  • Increases bone formation without suppressing resorption
• Animal data:
  • Increased bone mass
  • Improved strength
• Status:
  • Preclinical / early translational
• Why this matters:
  • First small-molecule osteoanabolic not hormone-based

If this translates to humans, it’s huge.

---

2. iSN40 (Oligodeoxynucleotide Bone Drug)​

• What it is:
  • Short synthetic DNA fragment
• Mechanism:
  • Directly promotes osteoblast differentiation
• Research:
  • Increased bone formation in models
• Significance:
  • Not hormonal
  • Not antibody-based
  • New drug class entirely

Early, but conceptually very strong.

---

3. MSC-Derived Exosomes (Cell-Free Regeneration)​

• What they are:
  • Vesicles secreted by mesenchymal stem cells
• Mechanism:
  • Deliver miRNA + growth signals
  • Promote osteogenesis & angiogenesis
• Used with:
  • Hydrogels
  • Scaffolds
• Status:
  • Animal models
  • Early human research

This is regenerative medicine, not supplementation.

---

4. Smart Scaffolds / 3D-Printed Bone Matrices​

• Used for:
  • Bone defects
  • Skull, jaw, orthopedic injuries
• Features:
  • Mimic native bone stiffness
  • Release growth factors
  • Guide cell differentiation
• Not for:
  • Systemic bone growth
• But:
  • Extremely powerful locally

---

TIER 4 — ELECTRICAL / ULTRASOUND STIMULATION (LIMITED)​

• Low-intensity pulsed ultrasound (LIPUS):
  • Mixed evidence
  • Minor acceleration of fracture healing
• Electrical stimulation:
  • Helps non-unions
  • Weak anabolic effect systemically

These are adjuncts, not growth drivers.

---

TIER 5 — WHAT DOES NOT WORK (IMPORTANT)​

• Supplements claiming “bone growth” (boron, silica, strontium):
  • Marginal at best
• GH alone:
  • Does NOT grow adult bones
• Collagen supplements:
  • Structural support only
• “Growth plate reopening” compounds:
  • Pure fiction

If it doesn’t touch Wnt / PTH / mechanical signaling, it’s cope.

---

THE ACTUAL NO.1 STRATEGY (REALITY)​

If you ask:
“What is the single strongest way humans can grow bone?”
The honest answer is:

Everything else is secondary or experimental.

---

FINAL SYNTHESIS (HIGH-LEVEL TAKEAWAY)​

• Adult humans can grow bone
• They cannot grow longer bones without surgery
• The bone growth switch is:
  • Sclerostin suppression
  • Wnt activation
  • Mechanical strain
• Modern medicine can now override evolutionary brakes
• The future is:
  • Small-molecule osteoanabolics
  • Exosome-based regeneration
  • Gene-level modulation of bone signaling

Bone is not dead tissue.
It’s conservative tissue — and we’re finally learning how to argue with it.
If you want, next we can:

• Rank these specifically for facial bones
• Talk growth plates vs periosteal expansion
• Or design a maximal bone-anabolic stack (theoretical) without crossing into fantasy

Dnr for all hopefully js showing yall what it can acc do and how im shocked

 

[Godveil Heir]

 

[Circadex]

Biomax posts gbt slop *confirmed* *heartbreaking*

 

[Mandy]

Sadly,NO ONE is sourcing allat what you listed except abolo and Fuckass vitamin D and calcium. But nice shit anyways,goes really into detail and I mirin hard. Also ultrasound and electric stimulation is just cope.

 

[Mandy]

Sadly,NO ONE is sourcing allat what you listed except abolo and Fuckass vitamin D and calcium. But nice shit anyways,goes really into detail and I mirin hard. Also ultrasound and electric stimulation is just cope.

Wait fuck this AI fuck shit ass nigga autism can I just fuck my brain

 

[Biomaxx]

Sadly,NO ONE is sourcing allat what you listed except abolo and Fuckass vitamin D and calcium. But nice shit anyways,goes really into detail and I mirin hard. Also ultrasound and electric stimulation is just cope.

No way this nga read that. Dnr from me

 

[Circadex]

Wait fuck this AI fuck shit ass nigga autism can I just fuck my brain

it's not too late to delete your post

 

[Biomaxx]

Wait fuck this AI fuck shit ass nigga autism can I just fuck my brain

Omd bruh

 

[Biomaxx]

it's not too late to delete your post

Please dont that was so funny

 

[Circadex]

Please dont that was so funny

Biomaxx turns GBT and mandy is now retarded, and possibly illiterate

 

[Biomaxx]

Alright. I’ll compress everything into one clean, copy-pasteable text, no files, no UI tricks, no fluff. This is the true state of the art as of ~2025, from boring reality to genuinely exotic pharma.
I’m going to be very explicit about what actually grows bone, what only preserves it, and what is speculative but real.

---

FIRST: A hard truth you need upfront​

There are three fundamentally different goals people confuse:

1. Increase bone mineral density / thickness (osteogenesis)
2. Regenerate or heal bone (injury, defects)
3. Increase bone length / stature (growth plates or distraction)

Only #1 and #2 are realistically achievable without surgery in adults.
#3 is basically impossible once growth plates are fused, outside of distraction osteogenesis.
Everything below is ranked by real anabolic power on bone.

---

TIER 0 — BIOLOGICAL LIMITS (NON-NEGOTIABLE)​

• Long bone lengthening requires open growth plates or surgery
• Adult bone growth = thicker, denser, stronger bone, not longer
• Bone responds to:
  • Mechanical strain
  • Wnt/β-catenin signaling
  • PTH signaling
  • Suppression of sclerostin
  • Adequate mineral + hormonal environment

If a method doesn’t touch one of those, it’s cosmetic noise.

---

TIER 1 — STRONGEST REAL-WORLD BONE-BUILDERS (CLINICAL, PROVEN)​

These are the most powerful non-surgical ways humans have ever grown bone.

---

1. Romosozumab (Anti-Sclerostin Antibody)​

This is the current king.

• Mechanism:
  • Neutralizes sclerostin (SOST) → releases the Wnt brake
  • Simultaneously:
    • ↑ osteoblast activity (bone formation)
    • ↓ osteoclast activity (bone resorption)
• Effect:
  • ~10–13% lumbar spine BMD increase in 12 months
  • Works faster than teriparatide
  • Creates a rare “anabolic window”
• Clinical reality:
  • Approved for osteoporosis
  • Monthly injections
  • Limited to ~12 months due to cardiovascular risk signal
• Important insight:
  • Humans with genetic SOST deficiency have massive bones, facial overgrowth, increased height

This is as close as medicine has gotten to “turning bone growth back on.”

---

2. Teriparatide (PTH 1-34) & Abaloparatide​

Second place, still extremely powerful

• Mechanism:
  • Pulsed PTH signaling → osteoblast activation > osteoclasts
• Effect:
  • 8–10% BMD increases
  • Improves microarchitecture
• Limitations:
  • Less effective in cortical bone than romosozumab
  • Lifetime use capped (~2 years)
• Note:
  • Continuous PTH = bone loss
  • Pulsed PTH = bone gain

These drugs literally re-teach adult bone to form new matrix.

---

TIER 2 — STRONG SUPPORTERS (REQUIRED FOR MAX RESULTS)​

These won’t build bone alone, but without them, Tier 1 underperforms.

---

Mechanical Loading (Non-Negotiable)​

Bone only grows where force demands it.

• High-impact, axial, or torsional load:
  • Squats
  • Deadlifts
  • Jumping
  • Loaded carries
• Mechanism:
  • Mechanical strain ↓ sclerostin locally
  • Activates osteocytes → Wnt signaling
• Key:
  • Swimming & cycling do almost nothing for bone

No force → no signal → no growth.

---

Calcium + Vitamin D (Baseline)​

• Calcium: ~700–1000 mg/day
• Vitamin D: ~1000 IU/day (more if deficient)
• Purpose:
  • Supplies raw material
  • Enables mineralization
• Important:
  • These do not grow bone alone
  • They only allow growth to occur

---

Hormonal Sufficiency​

• Testosterone (men)
• Estrogen (women AND men, in correct balance)
• Thyroid not excessive
• Cortisol not chronically elevated

Bone hates stress hormones and hypogonadism.

---

TIER 3 — NICHE / EMERGING PHARMA (REAL BUT EXPERIMENTAL)​

This is where things get interesting.

---

1. GPR133 (ADGRD1) Agonists — e.g. AP503 (Preclinical)​

• Mechanism:
  • Activates osteoblast-specific GPCR
  • Increases bone formation without suppressing resorption
• Animal data:
  • Increased bone mass
  • Improved strength
• Status:
  • Preclinical / early translational
• Why this matters:
  • First small-molecule osteoanabolic not hormone-based

If this translates to humans, it’s huge.

---

2. iSN40 (Oligodeoxynucleotide Bone Drug)​

• What it is:
  • Short synthetic DNA fragment
• Mechanism:
  • Directly promotes osteoblast differentiation
• Research:
  • Increased bone formation in models
• Significance:
  • Not hormonal
  • Not antibody-based
  • New drug class entirely

Early, but conceptually very strong.

---

3. MSC-Derived Exosomes (Cell-Free Regeneration)​

• What they are:
  • Vesicles secreted by mesenchymal stem cells
• Mechanism:
  • Deliver miRNA + growth signals
  • Promote osteogenesis & angiogenesis
• Used with:
  • Hydrogels
  • Scaffolds
• Status:
  • Animal models
  • Early human research

This is regenerative medicine, not supplementation.

---

4. Smart Scaffolds / 3D-Printed Bone Matrices​

• Used for:
  • Bone defects
  • Skull, jaw, orthopedic injuries
• Features:
  • Mimic native bone stiffness
  • Release growth factors
  • Guide cell differentiation
• Not for:
  • Systemic bone growth
• But:
  • Extremely powerful locally

---

TIER 4 — ELECTRICAL / ULTRASOUND STIMULATION (LIMITED)​

• Low-intensity pulsed ultrasound (LIPUS):
  • Mixed evidence
  • Minor acceleration of fracture healing
• Electrical stimulation:
  • Helps non-unions
  • Weak anabolic effect systemically

These are adjuncts, not growth drivers.

---

TIER 5 — WHAT DOES NOT WORK (IMPORTANT)​

• Supplements claiming “bone growth” (boron, silica, strontium):
  • Marginal at best
• GH alone:
  • Does NOT grow adult bones
• Collagen supplements:
  • Structural support only
• “Growth plate reopening” compounds:
  • Pure fiction

If it doesn’t touch Wnt / PTH / mechanical signaling, it’s cope.

---

THE ACTUAL NO.1 STRATEGY (REALITY)​

If you ask:
“What is the single strongest way humans can grow bone?”
The honest answer is:

Everything else is secondary or experimental.

---

FINAL SYNTHESIS (HIGH-LEVEL TAKEAWAY)​

• Adult humans can grow bone
• They cannot grow longer bones without surgery
• The bone growth switch is:
  • Sclerostin suppression
  • Wnt activation
  • Mechanical strain
• Modern medicine can now override evolutionary brakes
• The future is:
  • Small-molecule osteoanabolics
  • Exosome-based regeneration
  • Gene-level modulation of bone signaling

Bone is not dead tissue.
It’s conservative tissue — and we’re finally learning how to argue with it.
If you want, next we can:

• Rank these specifically for facial bones
• Talk growth plates vs periosteal expansion
• Or design a maximal bone-anabolic stack (theoretical) without crossing into fantasy

Honestly shocked by the detail on this holy

 

[Biomaxx]

Biomaxx turns GBT and mandy is now retarded, and possibly illiterate

.gg downfall

 

[Mandy]

Biomax posts gbt slop *confirmed* *heartbreaking*

Shit is really heartbreaking, .gg downfall confirmed. Ye ye,how do you know I just mixed up the same words as you? Rest in peace Ray Peat

 

[Biomaxx]

Shit is really heartbreaking, .gg downfall confirmed. Ye ye,how do you know I just mixed up the same words as you? Rest in peace Ray Peat
View attachment 16948View attachment 16949View attachment 16950View attachment 16951View attachment 16952

The downward spiral of mandy, nga is losing his mind

 

[Circadex]

Shit is really heartbreaking, .gg downfall confirmed. Ye ye,how do you know I just mixed up the same words as you? Rest in peace Ray Peat
View attachment 16948View attachment 16949View attachment 16950View attachment 16951View attachment 16952

Were you in the hog triad edit?

 

[Mandy]

Were you in the hog triad edit?

Not exactly sure what you’re talking about

 

[Circadex]

Not exactly sure what you’re talking about

Tyler made some edit a while ago and im pretty sure you were in it. I recognise you from somewhere

 

[Mandy]

Tyler made some edit a while ago and im pretty sure you were in it. I recognise you from somewhere

Can you send it? I mean I don’t remembering being a edit but who’s this doppelganger

 

[Circadex]

Can you send it? I mean I don’t remembering being a edit but who’s this doppelganger

didn't download it i think

 

[Z1gler7]

Alright. I’ll compress everything into one clean, copy-pasteable text, no files, no UI tricks, no fluff. This is the true state of the art as of ~2025, from boring reality to genuinely exotic pharma.
I’m going to be very explicit about what actually grows bone, what only preserves it, and what is speculative but real.

---

FIRST: A hard truth you need upfront​

There are three fundamentally different goals people confuse:

1. Increase bone mineral density / thickness (osteogenesis)
2. Regenerate or heal bone (injury, defects)
3. Increase bone length / stature (growth plates or distraction)

Only #1 and #2 are realistically achievable without surgery in adults.
#3 is basically impossible once growth plates are fused, outside of distraction osteogenesis.
Everything below is ranked by real anabolic power on bone.

---

TIER 0 — BIOLOGICAL LIMITS (NON-NEGOTIABLE)​

• Long bone lengthening requires open growth plates or surgery
• Adult bone growth = thicker, denser, stronger bone, not longer
• Bone responds to:
  • Mechanical strain
  • Wnt/β-catenin signaling
  • PTH signaling
  • Suppression of sclerostin
  • Adequate mineral + hormonal environment

If a method doesn’t touch one of those, it’s cosmetic noise.

---

TIER 1 — STRONGEST REAL-WORLD BONE-BUILDERS (CLINICAL, PROVEN)​

These are the most powerful non-surgical ways humans have ever grown bone.

---

1. Romosozumab (Anti-Sclerostin Antibody)​

This is the current king.

• Mechanism:
  • Neutralizes sclerostin (SOST) → releases the Wnt brake
  • Simultaneously:
    • ↑ osteoblast activity (bone formation)
    • ↓ osteoclast activity (bone resorption)
• Effect:
  • ~10–13% lumbar spine BMD increase in 12 months
  • Works faster than teriparatide
  • Creates a rare “anabolic window”
• Clinical reality:
  • Approved for osteoporosis
  • Monthly injections
  • Limited to ~12 months due to cardiovascular risk signal
• Important insight:
  • Humans with genetic SOST deficiency have massive bones, facial overgrowth, increased height

This is as close as medicine has gotten to “turning bone growth back on.”

---

2. Teriparatide (PTH 1-34) & Abaloparatide​

Second place, still extremely powerful

• Mechanism:
  • Pulsed PTH signaling → osteoblast activation > osteoclasts
• Effect:
  • 8–10% BMD increases
  • Improves microarchitecture
• Limitations:
  • Less effective in cortical bone than romosozumab
  • Lifetime use capped (~2 years)
• Note:
  • Continuous PTH = bone loss
  • Pulsed PTH = bone gain

These drugs literally re-teach adult bone to form new matrix.

---

TIER 2 — STRONG SUPPORTERS (REQUIRED FOR MAX RESULTS)​

These won’t build bone alone, but without them, Tier 1 underperforms.

---

Mechanical Loading (Non-Negotiable)​

Bone only grows where force demands it.

• High-impact, axial, or torsional load:
  • Squats
  • Deadlifts
  • Jumping
  • Loaded carries
• Mechanism:
  • Mechanical strain ↓ sclerostin locally
  • Activates osteocytes → Wnt signaling
• Key:
  • Swimming & cycling do almost nothing for bone

No force → no signal → no growth.

---

Calcium + Vitamin D (Baseline)​

• Calcium: ~700–1000 mg/day
• Vitamin D: ~1000 IU/day (more if deficient)
• Purpose:
  • Supplies raw material
  • Enables mineralization
• Important:
  • These do not grow bone alone
  • They only allow growth to occur

---

Hormonal Sufficiency​

• Testosterone (men)
• Estrogen (women AND men, in correct balance)
• Thyroid not excessive
• Cortisol not chronically elevated

Bone hates stress hormones and hypogonadism.

---

TIER 3 — NICHE / EMERGING PHARMA (REAL BUT EXPERIMENTAL)​

This is where things get interesting.

---

1. GPR133 (ADGRD1) Agonists — e.g. AP503 (Preclinical)​

• Mechanism:
  • Activates osteoblast-specific GPCR
  • Increases bone formation without suppressing resorption
• Animal data:
  • Increased bone mass
  • Improved strength
• Status:
  • Preclinical / early translational
• Why this matters:
  • First small-molecule osteoanabolic not hormone-based

If this translates to humans, it’s huge.

---

2. iSN40 (Oligodeoxynucleotide Bone Drug)​

• What it is:
  • Short synthetic DNA fragment
• Mechanism:
  • Directly promotes osteoblast differentiation
• Research:
  • Increased bone formation in models
• Significance:
  • Not hormonal
  • Not antibody-based
  • New drug class entirely

Early, but conceptually very strong.

---

3. MSC-Derived Exosomes (Cell-Free Regeneration)​

• What they are:
  • Vesicles secreted by mesenchymal stem cells
• Mechanism:
  • Deliver miRNA + growth signals
  • Promote osteogenesis & angiogenesis
• Used with:
  • Hydrogels
  • Scaffolds
• Status:
  • Animal models
  • Early human research

This is regenerative medicine, not supplementation.

---

4. Smart Scaffolds / 3D-Printed Bone Matrices​

• Used for:
  • Bone defects
  • Skull, jaw, orthopedic injuries
• Features:
  • Mimic native bone stiffness
  • Release growth factors
  • Guide cell differentiation
• Not for:
  • Systemic bone growth
• But:
  • Extremely powerful locally

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TIER 4 — ELECTRICAL / ULTRASOUND STIMULATION (LIMITED)​

• Low-intensity pulsed ultrasound (LIPUS):
  • Mixed evidence
  • Minor acceleration of fracture healing
• Electrical stimulation:
  • Helps non-unions
  • Weak anabolic effect systemically

These are adjuncts, not growth drivers.

---

TIER 5 — WHAT DOES NOT WORK (IMPORTANT)​

• Supplements claiming “bone growth” (boron, silica, strontium):
  • Marginal at best
• GH alone:
  • Does NOT grow adult bones
• Collagen supplements:
  • Structural support only
• “Growth plate reopening” compounds:
  • Pure fiction

If it doesn’t touch Wnt / PTH / mechanical signaling, it’s cope.

---

THE ACTUAL NO.1 STRATEGY (REALITY)​

If you ask:
“What is the single strongest way humans can grow bone?”
The honest answer is:

Everything else is secondary or experimental.

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FINAL SYNTHESIS (HIGH-LEVEL TAKEAWAY)​

• Adult humans can grow bone
• They cannot grow longer bones without surgery
• The bone growth switch is:
  • Sclerostin suppression
  • Wnt activation
  • Mechanical strain
• Modern medicine can now override evolutionary brakes
• The future is:
  • Small-molecule osteoanabolics
  • Exosome-based regeneration
  • Gene-level modulation of bone signaling

Bone is not dead tissue.
It’s conservative tissue — and we’re finally learning how to argue with it.
If you want, next we can:

• Rank these specifically for facial bones
• Talk growth plates vs periosteal expansion
• Or design a maximal bone-anabolic stack (theoretical) without crossing into fantasy

dnr

 

[Circadex]

mood​

 

[mat]

What would the dosage for Romosozumab be per month?

 

[Biomaxx]

What would the dosage for Romosozumab be per month?

Nga multiply by 30 what