Forskolin to delay plate closure theory? (1 Viewer)

[EqBeliever]

Quick theory dump before anyone asks how it works :

Forskolin spikes cAMP hard by hitting adenylate cyclase directly. PTHrP (the thing that keeps plates open) works the exact same way: Gs → cAMP → blocks chondrocyte hypertrophy → delays maturation/closure.

Source 1
Source 2 ​

Cell studies show forskolin:

• Kills collagen X expression (hypertrophy marker)
• Keeps chondrocytes proliferative instead of blowing up into bone
• Mimics PTHrP's anti-hypertrophy effect
• 

In vivo rats: oral Coleus extract (forskolin source) made femurs longer in growing ones, better bone modeling, no early fusion reported.

Rat source 1
Rat source 2​

So theoretically at 16 (plates probably still open), ~50 mg pure forskolin could mildly mimic PTHrP systemically → slow hypertrophy a bit → maybe buy a few extra months of growth before E2 seals it.

Other perks from adult studies: small BF drop, lean gain, free T up, bone mass increase.

But.... :

• 0 human studies on height/plates in teens (or anyone)
• Oral absorption sucks, probably barely reaches growth plates
• High dose untested in puberty – could fuck BP, heart rate, stomach, hormones
• T bump might raise E2 → faster closure risk lol
• 
  ​

 

[Razi]

Another mentioning of forskolin
Dnr tho I only came here from the title

 

[EqBeliever]

Another mentioning of forskolin
Dnr tho I only came here from the title

Foreskin demon strikes once again

 

[Requiem]

Quick theory dump before anyone asks how it works :

Forskolin spikes cAMP hard by hitting adenylate cyclase directly. PTHrP (the thing that keeps plates open) works the exact same way: Gs → cAMP → blocks chondrocyte hypertrophy → delays maturation/closure.

Source 1
Source 2 ​

Cell studies show forskolin:

• Kills collagen X expression (hypertrophy marker)
• Keeps chondrocytes proliferative instead of blowing up into bone
• Mimics PTHrP's anti-hypertrophy effect
• 

In vivo rats: oral Coleus extract (forskolin source) made femurs longer in growing ones, better bone modeling, no early fusion reported.

Rat source 1
Rat source 2​

So theoretically at 16 (plates probably still open), ~50 mg pure forskolin could mildly mimic PTHrP systemically → slow hypertrophy a bit → maybe buy a few extra months of growth before E2 seals it.

Other perks from adult studies: small BF drop, lean gain, free T up, bone mass increase.

But.... :

• 0 human studies on height/plates in teens (or anyone)
• Oral absorption sucks, probably barely reaches growth plates
• High dose untested in puberty – could fuck BP, heart rate, stomach, hormones
• T bump might raise E2 → faster closure risk lol
• ​

Havent heard from u in a while nigga

 

[Requiem]

Another mentioning of forskolin
Dnr tho I only came here from the title

how can you dnr such a small thread is ur dopamine that high

 

[Razi]

how can you dnr such a small thread is ur dopamine that high

10+ hours a day of doomscrolling for years def did something to my brain

 

[Requiem]

10+ hours a day of doomscrolling for years def did something to my brain

make it 11

 

[koalaboy999]

Quick theory dump before anyone asks how it works :

Forskolin spikes cAMP hard by hitting adenylate cyclase directly. PTHrP (the thing that keeps plates open) works the exact same way: Gs → cAMP → blocks chondrocyte hypertrophy → delays maturation/closure.

Source 1
Source 2 ​

Cell studies show forskolin:

• Kills collagen X expression (hypertrophy marker)
• Keeps chondrocytes proliferative instead of blowing up into bone
• Mimics PTHrP's anti-hypertrophy effect
• 

In vivo rats: oral Coleus extract (forskolin source) made femurs longer in growing ones, better bone modeling, no early fusion reported.

Rat source 1
Rat source 2​

So theoretically at 16 (plates probably still open), ~50 mg pure forskolin could mildly mimic PTHrP systemically → slow hypertrophy a bit → maybe buy a few extra months of growth before E2 seals it.

Other perks from adult studies: small BF drop, lean gain, free T up, bone mass increase.

But.... :

• 0 human studies on height/plates in teens (or anyone)
• Oral absorption sucks, probably barely reaches growth plates
• High dose untested in puberty – could fuck BP, heart rate, stomach, hormones
• T bump might raise E2 → faster closure risk lol
• ​

nigher

 

[Razi]

make it 11

Yeh I added + for a reason

 

[Circadex]

just take AI

 

[EqBeliever]

just take AI

too lazy to do bloodwork every 6 weeks and i dont wanna fuck up ma iq

 

[Requiem]

Yeh I added + for a reason

yeah but saying 11 plus instead of 10 plus means you def get 11 hours and with 10 plus its a probability

 

[Razi]

too lazy to do bloodwork every 6 weeks and i dont wanna fuck up ma iq

Iq over ascending
Clavicular theyre following your ways

 

[Razi]

yeah but saying 11 plus instead of 10 plus means you def get 11 hours and with 10 plus its a probability

Mirin 8 inches just ruined my experience on this thread

 

[EqBeliever]

Iq over ascending
Clavicular theyre following your ways

this is not the "Clav" way i just prioritize my intelegence over something that i can even be 100 percent sure will ascend me

 

[Razi]

this is not the "Clav" way i just prioritize my intelegence over something that i can even be 100 percent sure will ascend me

I’m playing bro

 

[EqBeliever]

I’m playing bro

all good

 

[Razi]

all good

Yeh it better be all good or I will wipe you off the face of the earth

 

[Requiem]

Mirin 8 inches just ruined my experience on this thread

thanks but im only 5ft9 barefoot so

 

[EqBeliever]

nigher

what is this avi

 

[Razi]

thanks but im only 5ft9 barefoot so

Alright so 1:1 I height mog you and you dick mog me so we good

 

[EqBeliever]

Yeh it better be all good or I will wipe you off the face of the earth

insert flight scared gif*

 

[Razi]

insert flight scared gif*

Yeh I’m imagining this
Lolzers

 

[Requiem]

Alright so 1:1 I height mog you and you dick mog me so we good

how big are you down

 

[Razi]

how big are you down

⁵