LifeFuel Explaining mechanosensation along with mechanotransduction in full detail to demonstrate the superiority of bonesmashing (3 Viewers)

[atlanteancel]

Mechanosensation and Mechanotransduction

"the biological process of detecting and transducing mechanical forces- such as touch, sound, gravity, and pressure- into electrical or chemical cellular signals"
The process of converting mechanical forces into electrical signals (mechanotransduction) is possible by mechanoreceptor neurons

mechanoreceptor neuron on bone tissue is called "an osteocyte" ​

When an osteocyte is met with force, the movement of interstitial fluid in the narrow spaces around its cell body and dendritic processes in the lacuno-canalicular network cause the mechanosensitive ion channels to open, leading to rapid influx of ions (mainly Ca2)
The second scenario is that force causes intracellular electrical/ionic changes
The Ca2 influx or electrical change activates intracellular pathways (e.g., ERK/MAPK, Akt, Wnt/β-catenin signaling)

Ca2 influx- the entry of extracellular calcium ions into the cytoplasm through plasma membrane channels

Plasma membrane channels- specialized transmembrane proteins that form hydrophilic pores, allowing passive transport of ions, water, and small polar molecules across the lipid bilayer​

This alters gene expression, notably downregulating sclerostin (SOST) - a key inhibitor of bone formation
To the neighboring osteocyte what this does is- Signals propagate via gap junctions (primarily connexin-43, or Cx43) on the dendritic processes

These allow direct passage of small molecules like Ca2, IP3, or ATP between connected osteocytes

connexin-43/Cx43- responsible for intracellular communication
This creates a coordinated network response across the bone matrix​

To the effector cells on the bones surface, signals reach osteoblasts and osteoclasts
This, (very oversimplified because the process is very detailed and i had trouble finding good research) inhibits osteoclast activity and upregulates osteoblast activity
ERK/MAPK, Akt, Wnt/β-catenin signaling-key intracellular signaling cascades that osteocytes activate (or modulate) after sensing mechanical stimuli like fluid flow shear stress or cytoplasm/interstitial fluid movement

This is the end of my thread, i wish at least one person looks into what i said and considers bonesmashing.
I truly wish to help you.
IF you have any question ask me here or im dm's, i will gladly answer anything

​

 

[atlanteancel]

Any dnring i will consider ignorance

 

[Hyporoxin]

DNR​

 

[fent]

Dnr nigga!

 

[atlanteancel]

Mechanosensation and Mechanotransduction

"the biological process of detecting and transducing mechanical forces- such as touch, sound, gravity, and pressure- into electrical or chemical cellular signals"
The process of converting mechanical forces into electrical signals (mechanotransduction) is possible by mechanoreceptor neurons

mechanoreceptor neuron on bone tissue is called "an osteocyte" ​

When an osteocyte is met with force, the movement of interstitial fluid in the narrow spaces around its cell body and dendritic processes in the lacuno-canalicular network cause the mechanosensitive ion channels to open, leading to rapid influx of ions (mainly Ca2)
The second scenario is that force causes intracellular electrical/ionic changes
The Ca2 influx or electrical change activates intracellular pathways (e.g., ERK/MAPK, Akt, Wnt/β-catenin signaling)

Ca2 influx- the entry of extracellular calcium ions into the cytoplasm through plasma membrane channels

Plasma membrane channels- specialized transmembrane proteins that form hydrophilic pores, allowing passive transport of ions, water, and small polar molecules across the lipid bilayer​

This alters gene expression, notably downregulating sclerostin (SOST) - a key inhibitor of bone formation
To the neighboring osteocyte what this does is- Signals propagate via gap junctions (primarily connexin-43, or Cx43) on the dendritic processes

These allow direct passage of small molecules like Ca2, IP3, or ATP between connected osteocytes

connexin-43/Cx43- responsible for intracellular communication
This creates a coordinated network response across the bone matrix​

To the effector cells on the bones surface, signals reach osteoblasts and osteoclasts
This, (very oversimplified because the process is very detailed and i had trouble finding good research) inhibits osteoclast activity and upregulates osteoblast activity
ERK/MAPK, Akt, Wnt/β-catenin signaling-key intracellular signaling cascades that osteocytes activate (or modulate) after sensing mechanical stimuli like fluid flow shear stress or cytoplasm/interstitial fluid movement

This is the end of my thread, i wish at least one person looks into what i said and considers bonesmashing.
I truly wish to help you.
IF you have any question ask me here or im dm's, i will gladly answer anything

​

dnr faggot, ts shit so fake but im not gonna explain why

 

[Hauptmann]

NZK knew ts already

 

[goyboy.hero]

Mechanosensation and Mechanotransduction

"the biological process of detecting and transducing mechanical forces- such as touch, sound, gravity, and pressure- into electrical or chemical cellular signals"
The process of converting mechanical forces into electrical signals (mechanotransduction) is possible by mechanoreceptor neurons

mechanoreceptor neuron on bone tissue is called "an osteocyte" ​

When an osteocyte is met with force, the movement of interstitial fluid in the narrow spaces around its cell body and dendritic processes in the lacuno-canalicular network cause the mechanosensitive ion channels to open, leading to rapid influx of ions (mainly Ca2)
The second scenario is that force causes intracellular electrical/ionic changes
The Ca2 influx or electrical change activates intracellular pathways (e.g., ERK/MAPK, Akt, Wnt/β-catenin signaling)

Ca2 influx- the entry of extracellular calcium ions into the cytoplasm through plasma membrane channels

Plasma membrane channels- specialized transmembrane proteins that form hydrophilic pores, allowing passive transport of ions, water, and small polar molecules across the lipid bilayer​

This alters gene expression, notably downregulating sclerostin (SOST) - a key inhibitor of bone formation
To the neighboring osteocyte what this does is- Signals propagate via gap junctions (primarily connexin-43, or Cx43) on the dendritic processes

These allow direct passage of small molecules like Ca2, IP3, or ATP between connected osteocytes

connexin-43/Cx43- responsible for intracellular communication
This creates a coordinated network response across the bone matrix​

To the effector cells on the bones surface, signals reach osteoblasts and osteoclasts
This, (very oversimplified because the process is very detailed and i had trouble finding good research) inhibits osteoclast activity and upregulates osteoblast activity
ERK/MAPK, Akt, Wnt/β-catenin signaling-key intracellular signaling cascades that osteocytes activate (or modulate) after sensing mechanical stimuli like fluid flow shear stress or cytoplasm/interstitial fluid movement

This is the end of my thread, i wish at least one person looks into what i said and considers bonesmashing.
I truly wish to help you.
IF you have any question ask me here or im dm's, i will gladly answer anything

​

No

 

[brewtal_cell_pslVSappeal]

More then 3 sentences of text dnr dnr dnr

 

[FatRetard]

Hmm

 

[atlanteancel]

More then 3 sentences of text dnr dnr dnr

fuck you nigga

 

[brewtal_cell_pslVSappeal]

fuck you nigga

Dnr to much text in your reply