Serious Erdafitinib vs. TYRA-300 (15 Viewers)

[unauthorized]

Found a source for both. But TYRA-300 i way more expensive for the same period of usage

some guy on the internet tells me that tyra is better in all regards

But based on published data:

• Erdafitinib: FGFR3 IC50 = 3.0 nM (enzymatic assay)
• TYRA-300: FGFR3 IC50 = 11 nM (Ba/F3 cells)

By this metric, Erdafitinib appears significantly more potent, am i wrong? I understand TYRA-300 has better selectivity (FGFR3 vs. FGFR1/2/4), which translates to fewer off-target toxicities (hyperphosphatemia, etc.).
Question: For the sole goal of maximizing height by inhibiting FGFR3, why would I pay 10x more for a less potent, "safer" drug? What am I missing? Would you still pay for the safety profile if you didn't care about it? Like i don't really want to mess up my metabolic processes related to phosphorus and potentially go blind, is it really that serious, like is risks really that high if i will run erda approximately 1 year straight? or should i just buy TYRA?

 

[Judenbänker]

Tyra.

Doubt you got a legit source though lmao

 

[Hauptmann]

Erda is shit

 

[unauthorized]

Tyra.

Doubt you got a legit source though lmao

apperently legit, 99% purity

But why you're picking TYRA over Erda, can you briefly explain?

 

[Judenbänker]

Erdafitinib: FGFR3 IC50 = 3.0 nM (enzymatic assay)
TYRA-300: FGFR3 IC50 = 11 nM (Ba/F3 cells)

why are you comparing in vitro to in vivo?
obviously erda will have more potency there...
erdas in vivo potency is around 13nM while tyras in vitro potency is 1,6nM so tyra clears in both cases with proper comparison
(9-11 vs 13 / 1,6 vs 3)

 

[Judenbänker]

apperently legit, 99% purity

whats the price
bro found some tiktok vendor lmao
best source i know of is 7k+ for like 10g bro

But why you're picking TYRA over Erda, can you briefly explain?

I did earlier.
It mogs erda in every single aspect

 

[unauthorized]

whats the price
bro found some tiktok vendor lmao
best source i know of is 7k+ for like 10g bro

I did earlier.
It mogs erda in every single aspect

1g is 1,4k

 

[Judenbänker]

1g is 1,4k

ok fair could be better but yeah
where u buying still tho

 

[unauthorized]

reliable guy on telegram does reselling from his vendor

 

[TrueIncel333]

Found a source for both. But TYRA-300 i way more expensive for the same period of usage

some guy on the internet tells me that tyra is better in all regards

But based on published data:

• Erdafitinib: FGFR3 IC50 = 3.0 nM (enzymatic assay)
• TYRA-300: FGFR3 IC50 = 11 nM (Ba/F3 cells)

By this metric, Erdafitinib appears significantly more potent, am i wrong? I understand TYRA-300 has better selectivity (FGFR3 vs. FGFR1/2/4), which translates to fewer off-target toxicities (hyperphosphatemia, etc.).
Question: For the sole goal of maximizing height by inhibiting FGFR3, why would I pay 10x more for a less potent, "safer" drug? What am I missing? Would you still pay for the safety profile if you didn't care about it? Like i don't really want to mess up my metabolic processes related to phosphorus and potentially go blind, is it really that serious, like is risks really that high if i will run erda approximately 1 year straight? or should i just buy TYRA?

What’s the source?