since im Jewish they won't give me other colors, its sad
Blackpill Do I ascend or rope? (3 Viewers)
Blackpill
Do I ascend or rope?
- Thread starter medialcanthusropefuel
- Start date
saw some guy doing 15 iu on tiktok
Definetly trolling
he's 6ft underground now, rotten
andrey smaevs 120IU dosage is calling...
he pinned it on video bro View: https://www.tiktok.com/@heonhgh/video/7602094724219948318?lang=en-GB&q=moidy&t=1771194448807
Fuck hes gone
lmao no one in his comments even telling him
Since when peptides and gear became hardmaxx
i love you niggaOh and btw, presented by the beautifulbirthdefect :
Z x weight(KGS) / 7 x 3 = daily gh iu dose
Z = any number between 0.24-0.47Just a range to choose. Test will be good(and prolly better in a stand alone comp ig) and cheaper. Eitherway u should do a solid stack.
THE HGH FORMULA
thank you for sharing this knowledge with the needy goyim
will be copying this formatting so i can use it elsewhere
mirin intellect
idk if he specified his weight since i dnrd, but 13 iu is perfectly ok depending on weight
aforementioned formula that
VelocityAnt¹ posted would give you 14.1 iu daily max dose for a goy that weighed 70kg
congrats OP has acromegaly and insulin resistance nowmirin intellect
idk if he specified his weight since i dnrd, but 13 iu is perfectly ok depending on weight
aforementioned formula that
neither occurs from +2.0 igf1 z score, which is the actual goal
prior formula is derived from dosing from the nih overview on gh dosing, which includes dosing practises on idiopathic short stature patients
disqualified
clinical gh dosing in teens w deficiency is 0.16-0.23/mg/kg/week, occasionally up to 0.3mg/kg/week
for 70kg teen, using 0.3mg/kg/week we get 9 ish IU/day
that is already upper end therapeutic dosing for a diagnosed pathology
13 iu means 0.43 mg/kg/week and that too for a deficient teen and not a normal one with normal gh axis
GH has direct anti insulin effects independent of IGF1
increases hepatic gluconeogenesis
decreases peripheral glucose uptake
increases lipolysis which elevates FFA and worsens insulin signaling
suppresses insulin receptor substrate pathways
my claim of acro was an exaggeration. but chronic supraphysiologic GH alone induces insulin resistance even when IGF1 is "within range". GH is not metabolically benign
And since GH stimulates systemic cell proliferation via IGF1,
long term elevated IGF1 has epidemiological associations with increased risk of certain malignancies
and about that formula, it assumes
linear GH -> IGF-1 response (false)
uniform hepatic sensitivity (false)
identical clearance rates (false)
stable endogenous GH suppression (false)
identical pubertal hormonal environments (false)
IGF1 response to GH varies massively between individuals,
two people can take the same IU dose and have completely different IGF1 levels.
thats why endocrinologists titrate based on serial IGF1 labs, glucose tolerance, lipids, thyroid status etc. and not a formula on some incel forum
with deficiency you're right, but this isnt about deficiency
its about being short without an underlying cause, aka idiopathic short stature, which is dosed at the rate i provided
in clinical settings, insulin resistance and diabetes isnt usually a problem, but in severe cases afaik metformin is used
you are correct about people having super different responses to gh, which is why i always specify in actual conversations that they should focus on the z score and not the actual iu dose. the formula is intentionally simple and just uses standard guidelines
wdym it has anti insulin effects independent of igf1? isnt that a given considering igf1 is literally insulin like in its metabolic action?
Yes ISS dosings can go up to .44mg/kg/week iirc
but,
ISS is still treated under pediatric endocrinology supervision, patients are monitored every 3 to6 months, IGF1 is kept within age adjusted reference range, glucose metabolism is monitored, therapy is stopped if adverse effects occur
13 IU is .43mg/kg/wk
this is at upper end of ISS protocol, dnd those protocols are not casual enhancement regimens but are carefully monitored.
so the issue isn’t whether 0.43 mg/kg/week exists in literature, it is whether a 16y old self administering 13 IU daily without confirmed ISS diagnosis, without endocrine monitoring (a proper one, i doubt OP even knows what a lipid profile is) is medically equivalent to supervised ISS treatment (it isnt)
in pediatric ISS therapy mild insulin resistance is common, fasting insulin often rises, glucose tolerance may worsen slightly, most cases remain compensated
Because doses are controlled, duration is limited, monitoring occurs and patients are screened
That doesnt mean supraphysiologic GH is metabolically benign
metformin is sometimes used, yes, but thats managing a side effect and npt a proof of harmlessness
this is closer to clinical reasoning imo
the GH IGF1 response curve is nonlinear and saturable
some individuals require low doses to reach +2 Z. others overshoot easily
but
maintaining someone chronically at +2 Z score is near the upper physiologic boundary
it increases mitogenic signaling via IGF1 receptor
activates PI3K/Akt and MAPK pathways
promotes cell proliferation and antiapoptotic signaling
i may have missed points but whatever, it's a bad day
for the ears grow ur hair a lil so it covers them
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