In rats?
Guide Dihydrotestosterone: Why it DOES NOT affect your JAW (Part 2) (2 Viewers)
Guide
Dihydrotestosterone: Why it DOES NOT affect your JAW (Part 2)
- Thread starter Dexter
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MC3T3-E1 cells are murine calvarial osteoblasts, they come from mouse skull not a human jaw. And also murine osteoblasts express 5AR differently than us.
it proves osteoblasts CAN respond to DHT if DHT is PRESENT, but it doesn't say whether DHT is present in human jaw during fetal development. human mandibular osteoblasts in vivo arent exposed to this conc (0.1ng/ml) because they dont express 5AR.
and from what ive read from that article, the researchers added exogenous DHT directly to the culture medium at 0.1ng/ml. this bypasses the entire question of whether human mandibular osteoblasts produce DHT from T.
"could be the in vitro basis for the efficacy of 5α-DHT in the treatment of androgen-deficient male osteoporosis."
osteoporosis is a condition of systemic androgenic deficiency. in a man with no T (hypogonadal), both T and DHT are low. giving exo DHT provides SOME androgenic signal to bone, but this in a way is just a rescue.
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