Cope Any osteoblast promoting drug is cope (1 Viewer)

[HailSanta]

People who promote osteoporosis drugs are ChatGPT warriors. They know nothing about how or why osteoporosis is relevant. romosozumabs effects are dominated by endosteal modelling/remodelling, not sustained periosteal expansion. all these so called “bone mass drugs” are the same way. this is due to periosteal expansion MAINLY BEING EPIGENETIC and there being no way of specifically targeting the areas you want. no, you cannot locally inject as you would need a crazy low half life and a crazy high effect, that doesn’t even consider that periosteal cells are very slow. I could list 50 other reasons why this take makes 0 sense but this alone is enough

 

[bob08674]

organ failure speedrun

 

[futureslayer51]

People who promote osteoporosis drugs are ChatGPT warriors. They know nothing about how or why osteoporosis is relevant. romosozumabs effects are dominated by endosteal modelling/remodelling, not sustained periosteal expansion. all these so called “bone mass drugs” are the same way. this is due to periosteal expansion MAINLY BEING EPIGENETIC and there being no way of specifically targeting the areas you want. no, you cannot locally inject as you would need a crazy low half life and a crazy high effect, that doesn’t even consider that periosteal cells are very slow. I could list 50 other reasons why this take makes 0 sense but this alone is enough

People who promote osteoporosis drugs are ChatGPT warriors. They know nothing about how or why osteoporosis is relevant. romosozumabs effects are dominated by endosteal modelling/remodelling, not sustained periosteal expansion. all these so called “bone mass drugs” are the same way. this is due to periosteal expansion MAINLY BEING EPIGENETIC and there being no way of specifically targeting the areas you want. no, you cannot locally inject as you would need a crazy low half life and a crazy high effect, that doesn’t even consider that periosteal cells are very slow. I could list 50 other reasons why this take makes 0 sense but this alone is enough

first non shitpost

 

[Mirilow]

People who promote osteoporosis drugs are ChatGPT warriors. They know nothing about how or why osteoporosis is relevant. romosozumabs effects are dominated by endosteal modelling/remodelling, not sustained periosteal expansion. all these so called “bone mass drugs” are the same way. this is due to periosteal expansion MAINLY BEING EPIGENETIC and there being no way of specifically targeting the areas you want. no, you cannot locally inject as you would need a crazy low half life and a crazy high effect, that doesn’t even consider that periosteal cells are very slow. I could list 50 other reasons why this take makes 0 sense but this alone is enough

Good

 

[futureslayer51]

Good

nigga stops repping me just because im gonna get 2k rep before him

 

[HailSanta]

People who promote osteoporosis drugs are ChatGPT warriors. They know nothing about how or why osteoporosis is relevant. romosozumabs effects are dominated by endosteal modelling/remodelling, not sustained periosteal expansion. all these so called “bone mass drugs” are the same way. this is due to periosteal expansion MAINLY BEING EPIGENETIC and there being no way of specifically targeting the areas you want. no, you cannot locally inject as you would need a crazy low half life and a crazy high effect, that doesn’t even consider that periosteal cells are very slow. I could list 50 other reasons why this take makes 0 sense but this alone is enough

Biomaxx is there any argument?

 

[Godveil Heir]

Based blackpilled truth

People who promote osteoporosis drugs are ChatGPT warriors. They know nothing about how or why osteoporosis is relevant. romosozumabs effects are dominated by endosteal modelling/remodelling, not sustained periosteal expansion. all these so called “bone mass drugs” are the same way. this is due to periosteal expansion MAINLY BEING EPIGENETIC and there being no way of specifically targeting the areas you want. no, you cannot locally inject as you would need a crazy low half life and a crazy high effect, that doesn’t even consider that periosteal cells are very slow. I could list 50 other reasons why this take makes 0 sense but this alone is enough

 

[HailSanta]

Based blackpilled truth


View attachment 24468

Yo dude can you delete my previous post that i posted on NEWS

 

[bob08674]

nigga stops repping me just because im gonna get 2k rep before him

300 posts and 800 rep in less then 24h

 

[dookiebootybutt59]

biomaxx please say something how am i gonna cope

 

[Mirilow]

nigga stops repping me just because im gonna get 2k rep before him

I just post sum dont check the other shit dont take it personal lol

 

[futureslayer51]

I just post sum dont check the other shit dont take it personal lol

youd better rep me from now on or im gonna get very angwy

 

[Biomaxx]

Biomaxx is there any argargument

yes, actually. *argument

Calling periosteal expansion “untargetable” is stupid . Sclerostin inhibition influences Wnt signaling in periosteal osteoblasts, and both animal and human data show periosteal apposition over time, (especially with mechanical loading.) Treating all bone drugs as equivalent also misses distinction between antiresorptives, modeling-based anabolics, ext. which act through different mechanisms.

 

[dookiebootybutt59]

yes, actually. *argument

Calling periosteal expansion “untargetable” is stupid . Sclerostin inhibition influences Wnt signaling in periosteal osteoblasts, and both animal and human data show periosteal apposition over time, (especially with mechanical loading.) Treating all bone drugs as equivalent also misses distinction between antiresorptives, modeling-based anabolics, ext. which act through different mechanisms.

yes daddy clock himm

 

[Biomaxx]

yes, actually. *argument

Calling periosteal expansion “untargetable” is stupid . Sclerostin inhibition influences Wnt signaling in periosteal osteoblasts, and both animal and human data show periosteal apposition over time, (especially with mechanical loading.) Treating all bone drugs as equivalent also misses distinction between antiresorptives, modeling-based anabolics, ext. which act through different mechanisms.

Can u also ping me back in an hour so I can come back when not high

 

[HailSanta]

yes, actually. *argument

Calling periosteal expansion “untargetable” is stupid . Sclerostin inhibition influences Wnt signaling in periosteal osteoblasts, and both animal and human data show periosteal apposition over time, (especially with mechanical loading.) Treating all bone drugs as equivalent also misses distinction between antiresorptives, modeling-based anabolics, ext. which act through different mechanisms.

Ofc there are exceptions but am referring to the majority

 

[Biomaxx]

Ofc there are exceptions but am referring to the majority

Decent take, ill let you off

 

[HailSanta]

Can u also ping me back in an hour so I can come back when not high

I will be sleeping bby also repping once in a while isn’t bad Good high

 

[Persona]

Lol