19382: Declassified (1 Viewer)

[antifoidaction]

do you have a source for ky-19382 as a cnp/npr agent?

 

[MirinZygos]

KY-19382
There has been some controversy over me posting this, and I want to clarify that under no circumstances will any compound sources and dosage advice be discussed. This is purely mechanistic and for high iq users only.

KY-19382 has been on the rise recently and whilst it is still a relatively unknown compound, im going to explain it to yall

pathway breakdown
KY-19382 runs through the CNP-NPR-B axis, this has effects downstream, dampening MAPK. This causes slower bone resorption and osteoclastogenesis, creating the ideal environment for osteoblast.

To pair with this it increaseses calcium and phosphate absorption and phosphate retention, this along with its CREB activation (bmp-2 signalling and osteocalcin expression) directly upregulates osteoblast.

-----------

The same cnp axis I mentioned is active in epiphyseal chondrocyte, so what does this mean for the growth plates?
delayed differentiation, hypertrophy and ossification.

this happens through 3 pathways-
PKG-11
FGF23
NPR-C/IHH

PKG-11
CNP binding indirectly activates cGMP surges which directly leads to heavy PKG-11 upregulation.

PKG-II phosphorylates
(SOX9,VASP,ROCK) suppress the chondrocyte transformation into a hypertrophic stage, alter cell adhesion and delay differentiation

FGF23
NPR-B directly suppresses FGF23
Lower FGF23=lower FGFR3
FGFR3 is fairly popular im sure you know how it works but ill give a lil analogy

Think of FGFR3 like border control
And growth signals are like the immigrants trying to cross the border (growth plates )
Less border control (FGFR3)
more immigrants (growth signals)

This allows more growth and also delays differentiation and ossification

NPR-C/IHH
KY-19382 reduces NPR-C count, NPR-C is what clears CNP. So less NPR-C means a longer CNP half life and stronger binding affinity. This CNP effect also modulates the IHH-PTHRP feedback loop.

IHH drives PTHRP to suppress differentiation and keep chondrocytes proliferating. CNP basically reinforces this.

--------------------------

KY-19382 upregualtes cGMP
cGMP upregulation causes increased blood flow to metabolically active tissue, this means there is a large increase in nutrition delivery, so more calcium, phosphates and amino acids to support bone remodeling. More nutrient delivery to osteoblast/clast. Also enhanced recovery in soft tissue

cGMP also modulates collagen synthesis. PKG activation in fibroblasts upregulates type I and type II collagen through CREB and SP1 activation, while increasing oxidase activity for better cross linking. This means denser bone, stronger connective tissue, and improved skin quality and faster hair growth.

------------

Fun fact- KY-19382 can make your eyes appear purple during usage

Sorry birthdefect and Fram3Let I hope I didnt leak too much

Ik this is a big change from my usual tone but I thought id prove my knowledge and more of my threads will be like this.

There really isnt alot of studies on this compound, im going of self taught and knowledge gathered from many others and some subscription ai research.

View attachment 37607
View attachment 37608
​

Spoiler: T@gs

determinism bob08674 Razi Synapzyzz realhmtn Ogre_cel O ogre carbon acromegalic djdnr.gg Primalwontsaveme hideandseek Mandy nineteen fgfr3 tmpll FoidSlayer 6ft1Cheat Circadex

​

Until next time
biomaxx

https://pmc.ncbi.nlm.nih.gov/articles/PMC8251890/

Could’ve included this aswell

 

[Biomaxx]

do you have a source for ky-19382 as a cnp/npr agent?

Did u not read the first fucking paragraph

 

[Biomaxx]

https://pmc.ncbi.nlm.nih.gov/articles/PMC8251890/

Could’ve included this aswell

Tysm , added

 

[antifoidaction]

Did u not read the first fucking paragraph

i mean a study

 

[tmpll]

KY-19382
There has been some controversy over me posting this, and I want to clarify that under no circumstances will any compound sources and dosage advice be discussed. This is purely mechanistic and for high iq users only.

KY-19382 has been on the rise recently and whilst it is still a relatively unknown compound, im going to explain it to yall

pathway breakdown
KY-19382 runs through the CNP-NPR-B axis, this has effects downstream, dampening MAPK. This causes slower bone resorption and osteoclastogenesis, creating the ideal environment for osteoblast.

To pair with this it increaseses calcium and phosphate absorption and phosphate retention, this along with its CREB activation (bmp-2 signalling and osteocalcin expression) directly upregulates osteoblast.

-----------

The same cnp axis I mentioned is active in epiphyseal chondrocyte, so what does this mean for the growth plates?
delayed differentiation, hypertrophy and ossification.

this happens through 3 pathways-
PKG-11
FGF23
NPR-C/IHH

PKG-11
CNP binding indirectly activates cGMP surges which directly leads to heavy PKG-11 upregulation.

PKG-II phosphorylates
(SOX9,VASP,ROCK) suppress the chondrocyte transformation into a hypertrophic stage, alter cell adhesion and delay differentiation

FGF23
NPR-B directly suppresses FGF23
Lower FGF23=lower FGFR3
FGFR3 is fairly popular im sure you know how it works but ill give a lil analogy

Think of FGFR3 like border control
And growth signals are like the immigrants trying to cross the border (growth plates )
Less border control (FGFR3)
more immigrants (growth signals)

This allows more growth and also delays differentiation and ossification

NPR-C/IHH
KY-19382 reduces NPR-C count, NPR-C is what clears CNP. So less NPR-C means a longer CNP half life and stronger binding affinity. This CNP effect also modulates the IHH-PTHRP feedback loop.

IHH drives PTHRP to suppress differentiation and keep chondrocytes proliferating. CNP basically reinforces this.

--------------------------

KY-19382 upregualtes cGMP
cGMP upregulation causes increased blood flow to metabolically active tissue, this means there is a large increase in nutrition delivery, so more calcium, phosphates and amino acids to support bone remodeling. More nutrient delivery to osteoblast/clast. Also enhanced recovery in soft tissue

cGMP also modulates collagen synthesis. PKG activation in fibroblasts upregulates type I and type II collagen through CREB and SP1 activation, while increasing oxidase activity for better cross linking. This means denser bone, stronger connective tissue, and improved skin quality and faster hair growth.

------------

Fun fact- KY-19382 can make your eyes appear purple during usage

Sorry birthdefect and Fram3Let I hope I didnt leak too much

Ik this is a big change from my usual tone but I thought id prove my knowledge and more of my threads will be like this.

There really isnt alot of studies on this compound, im going of self taught and knowledge gathered from many others and some subscription ai research.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8251890/ -from MirinZygos Ty

View attachment 37607
View attachment 37608
​

Spoiler: T@gs

determinism bob08674 Razi Synapzyzz realhmtn Ogre_cel O ogre carbon acromegalic djdnr.gg Primalwontsaveme hideandseek Mandy nineteen fgfr3 tmpll FoidSlayer 6ft1Cheat Circadex
Mirin

​

Until next time
biomaxx

dnr ill read later seems interesting because i saw Lewis talking abt purple eyes

 

[Biomaxx]

KY-19382
There has been some controversy over me posting this, and I want to clarify that under no circumstances will any compound sources and dosage advice be discussed. This is purely mechanistic and for high iq users only.

KY-19382 has been on the rise recently and whilst it is still a relatively unknown compound, im going to explain it to yall

pathway breakdown
KY-19382 runs through the CNP-NPR-B axis, this has effects downstream, dampening MAPK. This causes slower bone resorption and osteoclastogenesis, creating the ideal environment for osteoblast.

To pair with this it increaseses calcium and phosphate absorption and phosphate retention, this along with its CREB activation (bmp-2 signalling and osteocalcin expression) directly upregulates osteoblast.

-----------

The same cnp axis I mentioned is active in epiphyseal chondrocyte, so what does this mean for the growth plates?
delayed differentiation, hypertrophy and ossification.

this happens through 3 pathways-
PKG-11
FGF23
NPR-C/IHH

PKG-11
CNP binding indirectly activates cGMP surges which directly leads to heavy PKG-11 upregulation.

PKG-II phosphorylates
(SOX9,VASP,ROCK) suppress the chondrocyte transformation into a hypertrophic stage, alter cell adhesion and delay differentiation

FGF23
NPR-B directly suppresses FGF23
Lower FGF23=lower FGFR3
FGFR3 is fairly popular im sure you know how it works but ill give a lil analogy

Think of FGFR3 like border control
And growth signals are like the immigrants trying to cross the border (growth plates )
Less border control (FGFR3)
more immigrants (growth signals)

This allows more growth and also delays differentiation and ossification

NPR-C/IHH
KY-19382 reduces NPR-C count, NPR-C is what clears CNP. So less NPR-C means a longer CNP half life and stronger binding affinity. This CNP effect also modulates the IHH-PTHRP feedback loop.

IHH drives PTHRP to suppress differentiation and keep chondrocytes proliferating. CNP basically reinforces this.

--------------------------

KY-19382 upregualtes cGMP
cGMP upregulation causes increased blood flow to metabolically active tissue, this means there is a large increase in nutrition delivery, so more calcium, phosphates and amino acids to support bone remodeling. More nutrient delivery to osteoblast/clast. Also enhanced recovery in soft tissue

cGMP also modulates collagen synthesis. PKG activation in fibroblasts upregulates type I and type II collagen through CREB and SP1 activation, while increasing oxidase activity for better cross linking. This means denser bone, stronger connective tissue, and improved skin quality and faster hair growth.

------------

Fun fact- KY-19382 can make your eyes appear purple during usage

Sorry birthdefect and Fram3Let I hope I didnt leak too much

Ik this is a big change from my usual tone but I thought id prove my knowledge and more of my threads will be like this.

There really isnt alot of studies on this compound, im going of self taught and knowledge gathered from many others and some subscription ai research.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8251890/ -from MirinZygos Ty

View attachment 37607
View attachment 37608
​

Spoiler: T@gs

determinism bob08674 Razi Synapzyzz realhmtn Ogre_cel O ogre carbon acromegalic djdnr.gg Primalwontsaveme hideandseek Mandy nineteen fgfr3 tmpll FoidSlayer 6ft1Cheat Circadex
Mirin

​

Until next time
biomaxx

Status- bumped

 

[acromegalic]

Just made me experience the Dunning-Kreuger effect first hand. Holy shit I have so much to learn. From what I gather, this molecule improves nutrient delivery to the chondrocytes while simultaneously preventing ossification? Seems to have a lot of potential. Love the analogy you used btw

Mirin hard, bump.

 

[birthdefect]

KY-19382
There has been some controversy over me posting this, and I want to clarify that under no circumstances will any compound sources and dosage advice be discussed. This is purely mechanistic and for high iq users only.

KY-19382 has been on the rise recently and whilst it is still a relatively unknown compound, im going to explain it to yall

pathway breakdown
KY-19382 runs through the CNP-NPR-B axis, this has effects downstream, dampening MAPK. This causes slower bone resorption and osteoclastogenesis, creating the ideal environment for osteoblast.

To pair with this it increaseses calcium and phosphate absorption and phosphate retention, this along with its CREB activation (bmp-2 signalling and osteocalcin expression) directly upregulates osteoblast.

-----------

The same cnp axis I mentioned is active in epiphyseal chondrocyte, so what does this mean for the growth plates?
delayed differentiation, hypertrophy and ossification.

this happens through 3 pathways-
PKG-11
FGF23
NPR-C/IHH

PKG-11
CNP binding indirectly activates cGMP surges which directly leads to heavy PKG-11 upregulation.

PKG-II phosphorylates
(SOX9,VASP,ROCK) suppress the chondrocyte transformation into a hypertrophic stage, alter cell adhesion and delay differentiation

FGF23
NPR-B directly suppresses FGF23
Lower FGF23=lower FGFR3
FGFR3 is fairly popular im sure you know how it works but ill give a lil analogy

Think of FGFR3 like border control
And growth signals are like the immigrants trying to cross the border (growth plates )
Less border control (FGFR3)
more immigrants (growth signals)

This allows more growth and also delays differentiation and ossification

NPR-C/IHH
KY-19382 reduces NPR-C count, NPR-C is what clears CNP. So less NPR-C means a longer CNP half life and stronger binding affinity. This CNP effect also modulates the IHH-PTHRP feedback loop.

IHH drives PTHRP to suppress differentiation and keep chondrocytes proliferating. CNP basically reinforces this.

--------------------------

KY-19382 upregualtes cGMP
cGMP upregulation causes increased blood flow to metabolically active tissue, this means there is a large increase in nutrition delivery, so more calcium, phosphates and amino acids to support bone remodeling. More nutrient delivery to osteoblast/clast. Also enhanced recovery in soft tissue

cGMP also modulates collagen synthesis. PKG activation in fibroblasts upregulates type I and type II collagen through CREB and SP1 activation, while increasing oxidase activity for better cross linking. This means denser bone, stronger connective tissue, and improved skin quality and faster hair growth.

------------

Fun fact- KY-19382 can make your eyes appear purple during usage

Sorry birthdefect and Fram3Let I hope I didnt leak too much

Ik this is a big change from my usual tone but I thought id prove my knowledge and more of my threads will be like this.

There really isnt alot of studies on this compound, im going of self taught and knowledge gathered from many others and some subscription ai research.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8251890/ -from MirinZygos Ty

View attachment 37607
View attachment 37608
​

Spoiler: T@gs

determinism bob08674 Razi Synapzyzz realhmtn Ogre_cel O ogre carbon acromegalic djdnr.gg Primalwontsaveme hideandseek Mandy nineteen fgfr3 tmpll FoidSlayer 6ft1Cheat Circadex
Mirin

​

Until next time
biomaxx

YO NIGGA WTF
did you use the wrong compoudn? not a single molecule is true
ky has literally nothing to do with cnp bro you gotta delete this deadass

and wdym it can make your eyes appear purple
i think i said that to you as a joke cus i wanted my eyes to turn purple, that shit is not happening tho sadly
broooo nigga this looks like it was written for a different compound, probably the biggest biomax blunder of all time

 

[birthdefect]

https://pmc.ncbi.nlm.nih.gov/articles/PMC8251890/

Could’ve included this aswell

jfl even in this article it mentions the real moa which i wrote about in my thread
cxxc5 - dvl inhibition and gsk3b inhibition

 

[birthdefect]

Just made me experience the Dunning-Kreuger effect first hand. Holy shit I have so much to learn. From what I gather, this molecule improves nutrient delivery to the chondrocytes while simultaneously preventing ossification? Seems to have a lot of potential. Love the analogy you used btw

Mirin hard, bump.

nooooo nigga actual cnp modulation does that
https://looksmax.gg/threads/potential-for-ky19382-on-longitudinal-growth.18179/
read this for more info, tho it is unformatted garbage
imagine i wrote properly formatted threads

 

[Biomaxx]

YO NIGGA WTF
did you use the wrong compoudn? not a single molecule is true
ky has literally nothing to do with cnp bro you gotta delete this deadass

and wdym it can make your eyes appear purple
i think i said that to you as a joke cus i wanted my eyes to turn purple, that shit is not happening tho sadly
broooo nigga this looks like it was written for a different compound, probably the biggest biomax blunder of all time

Nigga what ? Are u fr ?

 

[Biomaxx]

YO NIGGA WTF
did you use the wrong compoudn? not a single molecule is true
ky has literally nothing to do with cnp bro you gotta delete this deadass

and wdym it can make your eyes appear purple
i think i said that to you as a joke cus i wanted my eyes to turn purple, that shit is not happening tho sadly
broooo nigga this looks like it was written for a different compound, probably the biggest biomax blunder of all time

Shit, I js fucking stemmed of pathways. Fuck bro

 

[Biomaxx]

Shit, I js fucking stemmed of pathways. Fuck bro

carbon can u delete this thread please it is misinformation.

 

[Biomaxx]

Crazy shit man, I pretty much got its effects down is js used to completely wrong pathway ? I need to stop writing threads high fml

 

[birthdefect]

Shit, I js fucking stemmed of pathways. Fuck bro

wdym stemmed of?
can you elab on what happened, genuinely curious

 

[birthdefect]

Crazy shit man, I pretty much got its effects down is js used to completely wrong pathway ? I need to stop writing threads high fml

nah like literally nothing is correct
idk if a compound like this even exists

 

[Biomaxx]

wdym stemmed of?
can you elab on what happened, genuinely curious

I acc do not know, it think I js started writing on cnp . Fml, sober day 1

 

[Biomaxx]

Machiavellian Synapzyzz dior

Please delete, threads is misinformation
Ill post a rewrite tonight

 

[birthdefect]

I acc do not know, it think I js started writing on cnp . Fml, sober day 1

alr gl nigga

Machiavellian Synapzyzz dior

Please delete, threads is misinformation
Ill post a rewrite tonight

if you want you can use my thread as an encyclopedia, afaik everything in there is true

 

[MirinZygos]

YO NIGGA WTF
did you use the wrong compoudn? not a single molecule is true
ky has literally nothing to do with cnp bro you gotta delete this deadass

and wdym it can make your eyes appear purple
i think i said that to you as a joke cus i wanted my eyes to turn purple, that shit is not happening tho sadly
broooo nigga this looks like it was written for a different compound, probably the biggest biomax blunder of all time

Fr I was confused the whole time reading the thread because I could’ve sworn it was used for hair growth and not bones

 

[MirinZygos]

jfl even in this article it mentions the real moa which i wrote about in my thread
cxxc5 - dvl inhibition and gsk3b inhibition

Icl I didn’t read the whole article I just saw it before and said he would’ve talked about it

 

[birthdefect]

Fr I was confused the whole time reading the thread because I could’ve sworn it was used for hair growth and not bones

for both actually, cxxc5 is highly expressed in both hair and the growth plate

Icl I didn’t read the whole article I just saw it before and said he would’ve talked about it

this isnt the first time ive seen on here where people will link sources that they just dont read
whats going on here

 

[bob08674]

KY-19382
There has been some controversy over me posting this, and I want to clarify that under no circumstances will any compound sources and dosage advice be discussed. This is purely mechanistic and for high iq users only.

KY-19382 has been on the rise recently and whilst it is still a relatively unknown compound, im going to explain it to yall

pathway breakdown
KY-19382 runs through the CNP-NPR-B axis, this has effects downstream, dampening MAPK. This causes slower bone resorption and osteoclastogenesis, creating the ideal environment for osteoblast.

To pair with this it increaseses calcium and phosphate absorption and phosphate retention, this along with its CREB activation (bmp-2 signalling and osteocalcin expression) directly upregulates osteoblast.

-----------

The same cnp axis I mentioned is active in epiphyseal chondrocyte, so what does this mean for the growth plates?
delayed differentiation, hypertrophy and ossification.

this happens through 3 pathways-
PKG-11
FGF23
NPR-C/IHH

PKG-11
CNP binding indirectly activates cGMP surges which directly leads to heavy PKG-11 upregulation.

PKG-II phosphorylates
(SOX9,VASP,ROCK) suppress the chondrocyte transformation into a hypertrophic stage, alter cell adhesion and delay differentiation

FGF23
NPR-B directly suppresses FGF23
Lower FGF23=lower FGFR3
FGFR3 is fairly popular im sure you know how it works but ill give a lil analogy

Think of FGFR3 like border control
And growth signals are like the immigrants trying to cross the border (growth plates )
Less border control (FGFR3)
more immigrants (growth signals)

This allows more growth and also delays differentiation and ossification

NPR-C/IHH
KY-19382 reduces NPR-C count, NPR-C is what clears CNP. So less NPR-C means a longer CNP half life and stronger binding affinity. This CNP effect also modulates the IHH-PTHRP feedback loop.

IHH drives PTHRP to suppress differentiation and keep chondrocytes proliferating. CNP basically reinforces this.

--------------------------

KY-19382 upregualtes cGMP
cGMP upregulation causes increased blood flow to metabolically active tissue, this means there is a large increase in nutrition delivery, so more calcium, phosphates and amino acids to support bone remodeling. More nutrient delivery to osteoblast/clast. Also enhanced recovery in soft tissue

cGMP also modulates collagen synthesis. PKG activation in fibroblasts upregulates type I and type II collagen through CREB and SP1 activation, while increasing oxidase activity for better cross linking. This means denser bone, stronger connective tissue, and improved skin quality and faster hair growth.



------------

Fun fact- KY-19382 can make your eyes appear purple during usage

Sorry birthdefect and Fram3Let I hope I didnt leak too much

Ik this is a big change from my usual tone but I thought id prove my knowledge and more of my threads will be like this.

There really isnt alot of studies on this compound, im going of self taught and knowledge gathered from many others and some subscription ai research.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8251890/ -from MirinZygos Ty

View attachment 37607
View attachment 37608
​

Spoiler: T@gs

determinism bob08674 Razi Synapzyzz realhmtn Ogre_cel O ogre carbon acromegalic djdnr.gg Primalwontsaveme hideandseek Mandy nineteen fgfr3 tmpll FoidSlayer 6ft1Cheat Circadex
Mirin

​

Until next time
biomaxx

Think of FGFR3 like border control
And growth signals are like the immigrants trying to cross the border (growth plates )

Thanks for saying this now i understand what youre talking abt
very good thread tho, thx for the tag too​

 

[Tabula Rasa]

KY-19382
There has been some controversy over me posting this, and I want to clarify that under no circumstances will any compound sources and dosage advice be discussed. This is purely mechanistic and for high iq users only.

KY-19382 has been on the rise recently and whilst it is still a relatively unknown compound, im going to explain it to yall

pathway breakdown
KY-19382 runs through the CNP-NPR-B axis, this has effects downstream, dampening MAPK. This causes slower bone resorption and osteoclastogenesis, creating the ideal environment for osteoblast.

To pair with this it increaseses calcium and phosphate absorption and phosphate retention, this along with its CREB activation (bmp-2 signalling and osteocalcin expression) directly upregulates osteoblast.​

Not a single molecule of evidence supports these claims.