[ped.master]

You hear alot on tikok and these typa forums that igfpbs are bad and "make igf1 unusable". But that is simply not the case. For my example I'm going to use igfpb3 (most effective igf1 binder). Igfpb3 essentially carrys the igf to where it need to be, limiting it would cause more free and usable igf1 at once BUT the igf would- not have any direction, likely die out before having any useful effective, attach to cancer cells highly increasing risk. Igfbp keep the igf1 stored in a 'vault' which is then opened by PAPP-A and similar enzymes ( pretty sure but not 100% so correct me if im wrong) when they're at the correct areas. Less igfpb can also cause faster epiphyseal plates fusing in adolescence as it allows more igf to reach the plates. If you take exogenous hgh the body will also increase igfpb and these acid chains (DYOR) and PAPP-A.

As always-
Correct me if im wrong I won't take it harshly
Much love bhais

 

[ped.master]

AI enhanced-
On social media and various online forums, IGF-binding proteins (IGFBPs) are often portrayed as “bad” because they make IGF-1 “unusable.” This interpretation is misleading. Taking IGFBP-3 as an example—the primary and most abundant IGF-1 carrier—it functions not to suppress IGF-1, but to regulate and deliver it safely. IGFBP-3 binds IGF-1 in the circulation, extending its half-life and ensuring that IGF-1 reaches appropriate tissues. Reducing IGFBP levels would indeed increase the proportion of free IGF-1, but this unbound hormone would lack direction, be rapidly degraded, and could more readily stimulate unwanted cell proliferation, increasing oncogenic risk. IGFBPs act as a controlled delivery system: IGF-1 is released locally when specific proteases such as pregnancy-associated plasma protein-A (PAPP-A) cleave the binding proteins in target tissues. Lower IGFBP levels during adolescence could also accelerate epiphyseal-plate fusion by exposing growth plates to excess IGF-1. In states of elevated growth hormone—such as with exogenous GH administration—the liver compensates by producing more IGF-1, IGFBP-3, and the acid-labile subunit (ALS), preserving this balance.

 

[Gigel]

Tales from Tuvalu mud hut

 

[iihatebeckys]

You hear alot on tikok and these typa forums that igfpbs are bad and "make igf1 unusable". But that is simply not the case. For my example I'm going to use igfpb3 (most effective igf1 binder). Igfpb3 essentially carrys the igf to where it need to be, limiting it would cause more free and usable igf1 at once BUT the igf would- not have any direction, likely die out before having any useful effective, attach to cancer cells highly increasing risk. Igfbp keep the igf1 stored in a 'vault' which is then opened by PAPP-A and similar enzymes ( pretty sure but not 100% so correct me if im wrong) when they're at the correct areas. Less igfpb can also cause faster epiphyseal plates fusing in adolescence as it allows more igf to reach the plates. If you take exogenous hgh the body will also increase igfpb and these acid chains (DYOR) and PAPP-A.

As always-
Correct me if im wrong I won't take it harshly
Much love bhais

high iq post