[ltbslayerr33]

some people think its dumb some think its good so what are your thoughts?

 

[dexter]

When a bone experiences direct trauma, the subperiosteal capillaries beneath the periosteum rupture which forms an hematoma. This will lift the periosteum (the bone’s outer membrane) away from the cortical bone, triggering inflammation and activating mechotrasduction. Now, mechotransduction is the biological process where mechanical stress converts into cellular signals that stimulate, growth and repair. The cambium layer of the periosteum becomes highly active when detached. Signaling pathways such as Runx2, TGF-B2 and Wnt/B-catenin are upregulated, generating MCSs to differentiate into OSTEOBLASTS. Then, the osteoblasts mineralize the hematoma, which calcifies into new bone tissue, all this to thick the bone making it look way more prominent.

If you hit your face the small blood vessels beneath the periosteum will rupture forming subperiosteal hematoma. But it aint a sign of bone growth cuz it’s simply an inflammatory response. The periosteum is literally js attached to the bone, meaning it only detaches under high impact/near fracture trauma. And when that shit actually happens, the body’s response is driven by cytokine mediated inflammation and not mechanotransduction.

In actual mechanotransduction the osteocytes act as piezoelectric transducers and convert it into biochem signals thru pathways like Wnt/beta catenin, YAP/TAZ and Runx2 (they orchestrate osteoblastogenesis and matrix deposition). These tell mesenchymal stem cells to become osteoblasts which forms new bone in a normal way and not whatever this is. But blunt trauma does NOT create that pattern snd what it does is destroy local microstructure, triggers immune cells and lead to fibrosis (NOT GROWTH)

Any osteoid elaboration that arises is JUST pathologic ossification which is an irregular, fibro osseous callus and NOT a controlled hypertrophic adaptation by bonesmashing.

Blunt trauma (bonesmashing) generates retarded amounts of shear forces that fuck up local microarchitecture which then replace organized strain gradients w necrotic microfoci