What is retatrutide?
retatrutide is a "Triple g" investigational weight loss drug in its later trialing stage being developed by eli lilly. (The people who made zepbound/mounjaro)
ELI5: it's eli lillys end result when they keep adding shit onto ozempic and hope for the best (And it's worked amazingly so far)
How does retatrutide work? retatrutide works by targeting 3 receptors: Glp-1, GIP & glucagon. These receptors all work together to provide a synergistic combination resulting in superior weightloss to any drug on the market.
ELI5: it's eli lillys end result when they keep adding shit onto ozempic and hope for the best (And it's worked amazingly so far)
How does retatrutide work? retatrutide works by targeting 3 receptors: Glp-1, GIP & glucagon. These receptors all work together to provide a synergistic combination resulting in superior weightloss to any drug on the market.
Now, what do the receptors actually do?
Well, glp-1: GLP-1 (Glucagon-like peptide-1)
Works by doing the following:
1. Slows digestion. It slows down the emptying of the gut to keep you feeling fuller, for longer.
2. Sends signals to your brain that are responsible for appetite; reducing appetite.
3. Stimulates insulin production; increases insulin when blood sugar is high, and lowers blood sugar via reducing glucose
(This is actually a very sought after a effect, since most fatcels with have prediabetes)
GIP (glucose-dependent insulinotropic polypeptide)
1. Pretty much the same mechanisms as GLP-1 but by targeting different areas to get the effects. Also has slight effects on gastric acid secretetion
2. Just some extras: regulates lipid and glucose metabolism in tissues such as the liver, can promote slight bone mineral density benefits, helps with GI effects.
glucagon receptor:
1. Via binding to it's receptor, glucagon increases energy expenditure, making you burn more calories.
2. increases lipid metabolism (Using fat as energy)
(I'd add some more but honestly, nothing relevant i thought needed adding)
Now, what can you expect to see from retatrutide in terms of results?
I'll attach a weightloss graph & some results down below ⬇
As we can see from this image, dosing past 8mg is effectively useless and not economical, which brings me onto my next point:
The dosing ⬇
Typically, the dosing of retatrutide is something many get wrong, and unfortunately pay the price. Typically by pure misery for a week or more. I cannot stress it enough when it comes to any GLP-1 medication; do not be impatient with dosing. if you think it's a good idea to start at anything over 2mg, you're retarded. And your toilet will suffer just as you will.
The most common retatrutide dosing would go something like this:
(This would be for 25-30%+ bf individuals)
1mg for 2 weeks
2mg for 2 weeks
4mg for 2/4 weeks
6mg for 2/4 weeks
8mg indefinitely.
(You can go higher than 8mg, but only do so if the effects on 8mg maintenance start to wear off. If for some reason you haven't reached your goal by the time you escalate to 12mg, I'd introduce cagrilintide & dial the retatrutide down to 6mg.)
If you're just looking for a slight cutting aid, escalate like i said & stop at 4mg. Why you may ask? well, the glucagon receptor only seems to kick in at dosages 4mg and up. Which is responsible for increased energy expenditure and lipids.
The most common retatrutide dosing would go something like this:
(This would be for 25-30%+ bf individuals)
1mg for 2 weeks
2mg for 2 weeks
4mg for 2/4 weeks
6mg for 2/4 weeks
8mg indefinitely.
(You can go higher than 8mg, but only do so if the effects on 8mg maintenance start to wear off. If for some reason you haven't reached your goal by the time you escalate to 12mg, I'd introduce cagrilintide & dial the retatrutide down to 6mg.)
If you're just looking for a slight cutting aid, escalate like i said & stop at 4mg. Why you may ask? well, the glucagon receptor only seems to kick in at dosages 4mg and up. Which is responsible for increased energy expenditure and lipids.
SIDE EFFECTS
The typical GI side effects of GLP-1 based medications; nausea, vomiting, diarrhea, and constipation. Other side effects may include: headaches, increased skin-sensitivity, fatigue, and increased heart rate. Though, most of these can be avoided by basic electrolyte & vitamin supplementation.
If you experience anything serious, stop injecting and go to the doctors. And be honest; no-one can help you if you're not honest.
If you experience anything serious, stop injecting and go to the doctors. And be honest; no-one can help you if you're not honest.
How to not feel like shit, and risk serious long-term complications. ⬇
Since retatrutide reduces food intake significantly, you'll have to sufficiently supplement everything you'll be missing.
Take a good multi-vitamin & electrolyte supplement.
Here are some i recommend ⬇
Reconstitution & injection technique.
Go check out this guide: "How to reconstitute your peptide" by
Biomaxx. It's a simple, beginner-friendly guide about reconstitution & pinning; it's a must if you're considering retatrutide.
Biomaxx. It's a simple, beginner-friendly guide about reconstitution & pinning; it's a must if you're considering retatrutide.
Sourcing and such ⬇
sourcing retatrutide, or just peptides in general, is something most newcomers will struggle with. And most likely raped by jews *cough* Monica...
So I'll attach a valid pricing example & website to help you not get scammed. ⬇
Note: 1 box equals 10 vials.
This website, GLP-1 forum, is amazing for sourcing all types of peptides.
It's vendors section is highly regulated, and the community is extremely helpful.
⬇
GLP-1 forum link:
Anyways, that's basically it. Been putting this off for ages now, thought I'd finish it. Hope it helps you.
So I'll attach a valid pricing example & website to help you not get scammed. ⬇
Note: 1 box equals 10 vials.
This website, GLP-1 forum, is amazing for sourcing all types of peptides.
It's vendors section is highly regulated, and the community is extremely helpful.
⬇
GLP-1 forum link:
Anyways, that's basically it. Been putting this off for ages now, thought I'd finish it. Hope it helps you.
