birthdefect
pray to the purple powder
- Joined
- Jan 7, 2026
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this is gonna be a very fast thread unlike the other ones where i rambled on for too long since i just heard about this.
only talking about this cus these are literally impossible to source rn, just sharing science. PCO371 and EB631 are both research chemicals act as oral agonists of the pthrp1 receptor, the same one teriparatide and abaloparatide act on. they both have actually had human trials, with PCO371 being a little ethically questionable but thats ok. they both are (or were) in trial for osteoporosis and hypoparathyroidism.
for anyone wondering, pth/pthrp analogues arent effective for longitudinal growth because they promote bone formation (might actually be counter productive), rather they keep proliferating chondrocytes young, preventing them from hypertrophying. this is done through the ihh pthrp feedback loop, and they arent the only compounds that modulate this feedback loop
just wanted to share this cool shit
tagging people from my other post
Biomaxx
oldfag
VelocityAnt¹
BastiHgH
only talking about this cus these are literally impossible to source rn, just sharing science. PCO371 and EB631 are both research chemicals act as oral agonists of the pthrp1 receptor, the same one teriparatide and abaloparatide act on. they both have actually had human trials, with PCO371 being a little ethically questionable but thats ok. they both are (or were) in trial for osteoporosis and hypoparathyroidism.
for anyone wondering, pth/pthrp analogues arent effective for longitudinal growth because they promote bone formation (might actually be counter productive), rather they keep proliferating chondrocytes young, preventing them from hypertrophying. this is done through the ihh pthrp feedback loop, and they arent the only compounds that modulate this feedback loop
just wanted to share this cool shit
tagging people from my other post

