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Theory possible oral pth/pthrp analogues? (short thread)

birthdefect

pray to the purple powder
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this is gonna be a very fast thread unlike the other ones where i rambled on for too long since i just heard about this.

only talking about this cus these are literally impossible to source rn, just sharing science. PCO371 and EB631 are both research chemicals act as oral agonists of the pthrp1 receptor, the same one teriparatide and abaloparatide act on. they both have actually had human trials, with PCO371 being a little ethically questionable but thats ok. they both are (or were) in trial for osteoporosis and hypoparathyroidism.

for anyone wondering, pth/pthrp analogues arent effective for longitudinal growth because they promote bone formation (might actually be counter productive), rather they keep proliferating chondrocytes young, preventing them from hypertrophying. this is done through the ihh pthrp feedback loop, and they arent the only compounds that modulate this feedback loop

just wanted to share this cool shit

tagging people from my other post
Biomaxx Biomaxx oldfag oldfag VelocityAnt¹ VelocityAnt¹ BastiHgH BastiHgH
 

cp_

Iron
Joined
Dec 9, 2025
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this is gonna be a very fast thread unlike the other ones where i rambled on for too long since i just heard about this.

only talking about this cus these are literally impossible to source rn, just sharing science. PCO371 and EB631 are both research chemicals act as oral agonists of the pthrp1 receptor, the same one teriparatide and abaloparatide act on. they both have actually had human trials, with PCO371 being a little ethically questionable but thats ok. they both are (or were) in trial for osteoporosis and hypoparathyroidism.

for anyone wondering, pth/pthrp analogues arent effective for longitudinal growth because they promote bone formation (might actually be counter productive), rather they keep proliferating chondrocytes young, preventing them from hypertrophying. this is done through the ihh pthrp feedback loop, and they arent the only compounds that modulate this feedback loop

just wanted to share this cool shit

tagging people from my other post
Biomaxx Biomaxx oldfag oldfag VelocityAnt¹ VelocityAnt¹ BastiHgH BastiHgH
dnr since your avi distracting me from reading it
 

cp_

Iron
Joined
Dec 9, 2025
Posts
500
Reputation
536
this is gonna be a very fast thread unlike the other ones where i rambled on for too long since i just heard about this.

only talking about this cus these are literally impossible to source rn, just sharing science. PCO371 and EB631 are both research chemicals act as oral agonists of the pthrp1 receptor, the same one teriparatide and abaloparatide act on. they both have actually had human trials, with PCO371 being a little ethically questionable but thats ok. they both are (or were) in trial for osteoporosis and hypoparathyroidism.

for anyone wondering, pth/pthrp analogues arent effective for longitudinal growth because they promote bone formation (might actually be counter productive), rather they keep proliferating chondrocytes young, preventing them from hypertrophying. this is done through the ihh pthrp feedback loop, and they arent the only compounds that modulate this feedback loop

just wanted to share this cool shit

tagging people from my other post
Biomaxx Biomaxx oldfag oldfag VelocityAnt¹ VelocityAnt¹ BastiHgH BastiHgH
good thread anyways
 

Biomaxx

Ldaring or pinning
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this is gonna be a very fast thread unlike the other ones where i rambled on for too long since i just heard about this.

only talking about this cus these are literally impossible to source rn, just sharing science. PCO371 and EB631 are both research chemicals act as oral agonists of the pthrp1 receptor, the same one teriparatide and abaloparatide act on. they both have actually had human trials, with PCO371 being a little ethically questionable but thats ok. they both are (or were) in trial for osteoporosis and hypoparathyroidism.

for anyone wondering, pth/pthrp analogues arent effective for longitudinal growth because they promote bone formation (might actually be counter productive), rather they keep proliferating chondrocytes young, preventing them from hypertrophying. this is done through the ihh pthrp feedback loop, and they arent the only compounds that modulate this feedback loop

just wanted to share this cool shit

tagging people from my other post
Biomaxx Biomaxx oldfag oldfag VelocityAnt¹ VelocityAnt¹ BastiHgH BastiHgH

this is gonna be a very fast thread unlike the other ones where i rambled on for too long since i just heard about this.

only talking about this cus these are literally impossible to source rn, just sharing science. PCO371 and EB631 are both research chemicals act as oral agonists of the pthrp1 receptor, the same one teriparatide and abaloparatide act on. they both have actually had human trials, with PCO371 being a little ethically questionable but thats ok. they both are (or were) in trial for osteoporosis and hypoparathyroidism.

for anyone wondering, pth/pthrp analogues arent effective for longitudinal growth because they promote bone formation (might actually be counter productive), rather they keep proliferating chondrocytes young, preventing them from hypertrophying. this is done through the ihh pthrp feedback loop, and they arent the only compounds that modulate this feedback loop

just wanted to share this cool shit

tagging people from my other post
Biomaxx Biomaxx oldfag oldfag VelocityAnt¹ VelocityAnt¹ BastiHgH BastiHgH
Buuuuuumppppp
Thread 'PTH ANALOGS (very advanced and my thread to prove im not a dumb fuck)' https://looksmax.gg/threads/pth-ana...d-my-thread-to-prove-im-not-a-dumb-fuck.9202/
 

birthdefect

pray to the purple powder
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