Hey baby,after being temp banned Mandy decides to use it’s brain to work again!
So insulin, a topic no one likes to talk about. Mandy dislikes people fearing people for multiple reasons, but let’s get started with the basics
What is insulin?
This is pretty obvious but to get deeper. Insulin is a hormone that is doubled chained by 2 peptide chains,the A chain has 21 amino acids meanwhile the other peptide chain has 30. These both links are connected with 2 disulfide chains. It makes it a special and unique molecule structurally because usually hormones have 3 disulfide chains. Also insulin has a unusual and unique biosynthesis pathway:
1.Preproinsulin (triggered by peptide signal) -> 2.Preinsulin (2 disulfide chains and chains form) -> Insulin+C peptide (release from secretory granules) -> Full form systemic insulin.
Mechanisms of insulin.
Now naturally this synthesis occurs when your body picks up an intake of carbohydrates or protein, or generally both at the same time. During consumption synthesis of the hormone and it’s early release eventually has its onset,and it’s full unset is once the total glucose concentration from the consumption of it peaks. Pancreatic ẞ cells sense the increase in glucose GLUT2->ATP (agonism)->K channel closure-> influx in Ca2+ which leads to the essential insulin release.
View attachment IMG_2616.webp
What this would lead to is insulin would immediately get a demand signal from the Insulin receptor (IR) which already autophosphorylates upon binding.thid reaction causes mobilization of also IRS-1 and IRS-2.
This is where insulin’s main anabolic level comes in,the recruitment of both IR-1 and IR-2 causes a mass influx in PI3K which then contributes to PIP formation which essentially creates your final growth factor Akt which leads to further downstream effects. Akt is basically the central point of lots of downstream effects.
In terms of storing glycogen,GLUT4 which is triggered by Akt cause the GLUT4 vesicles to move to the membrane of the cell. Once it’s included into the membrane glucose floods that cell,glucose uptake into muscle increased 7~ folds in the matter of minutes due to this mechanism leading to the eventual “feeding” of glucose and storange of glycogen. Akt inhibits GSK-3 which triggered glycogen synthesis. Glycogen of a column of glucose connected by water,1g of glycogen holds about 3-4g of water.
Another nice thing about insulin is that it’s very anti catabolic,that’s why whenever someone says “I’m keto while cutting” Mandy finds them extremely stupid. What insulin does nicely is increases the activity the Amino acid transporter, indirectly keeps MTOR upregulated and prevents the general amino acid breakdown. When you want to get rid of fat the stupidest thing you could do is possibly go on no carbs, you are literally wasting muscle mass. Imsulin activates MTORC1 therefore increasing transition initiation and also increasing ribosomal activity. It also supresses proteolysis via inhibition of unibuitin-proteason pathway and simple autophagy.
Ever why eating carbs before a workout is ideal without the classic better efficiency of ATP? Mineral uptake,via ATPase and K+ and Na+ which support better motor nerve contraction,not by glucose oxidation but by Insulin itself. People like to say a low glycemic state is metabolically healthy,pretty false when you think of the elevated cortisol,poor thyroid conversion elevated free fatty acids.
Pretty fair to say that in conclusion,insulin is hella anabolic.
Fearmongering:Should you be scared of exogenous insulin?
A clear answer is absolutely not at all.
What do most people fear of insulin? HYPOGLYCEMIA. Now in terms Mandy,JFL if you’re scared of being hypoglycemic. People who get hypoglycemic while using insulin don’t know what the fuck they’re doing at all. First we have to fatal hypoglycemia cases.
Who dies from hypoglycemia? People who use an insulin pen and people who use a short acting insulin. Why does this play a difference? So you don’t make the same mistake! Many people die from simply misclicking their insulin pen,they misclick it to hundreds of IU’s unnoticed and them the person glucose depletes all at once and you’re instantly dead. What can you learn from that? Don’t use an insulin pen!, use a vial! With a vial you’ll have a more cleared and known dosage,you need precision to dose up which makes it better,IU per IU,you’ll know and unless you’re just a rock you can’t mess that up.
Also we talked about short acting insulins,that’s not what you need and that’s not what I recommend. What I do recommend is Lantus insulin,Insulin gargaline. If you saw my posts and advice before,you’ll constantly see me talk about “lantus insulin” so what is it? It’s a long acting insulin,unlike the short acting ones you only have to administer it only once a day compared to before every meal with a short acting one. What this offers is an almost non existent peak (no sudden or rapid hypoglycemia) and stable levels. Just once a day 30 minutes to 1 hour breakfast and then you’re ready for the day. Also you don’t need to worry about timing at all.
1x daily,in the morning,empty stomach,subcutaneous. When taken with GH,15-25IU is ideal.
Fuck,lots of work into this so I hope my effort gets appreciation so give reps thanks babes.
If you want advice personally
Tags:
Biomaxx
justnemat
Also A Admincel give me contributor Saar
So insulin, a topic no one likes to talk about. Mandy dislikes people fearing people for multiple reasons, but let’s get started with the basics
What is insulin?
This is pretty obvious but to get deeper. Insulin is a hormone that is doubled chained by 2 peptide chains,the A chain has 21 amino acids meanwhile the other peptide chain has 30. These both links are connected with 2 disulfide chains. It makes it a special and unique molecule structurally because usually hormones have 3 disulfide chains. Also insulin has a unusual and unique biosynthesis pathway:
1.Preproinsulin (triggered by peptide signal) -> 2.Preinsulin (2 disulfide chains and chains form) -> Insulin+C peptide (release from secretory granules) -> Full form systemic insulin.
Mechanisms of insulin.
Now naturally this synthesis occurs when your body picks up an intake of carbohydrates or protein, or generally both at the same time. During consumption synthesis of the hormone and it’s early release eventually has its onset,and it’s full unset is once the total glucose concentration from the consumption of it peaks. Pancreatic ẞ cells sense the increase in glucose GLUT2->ATP (agonism)->K channel closure-> influx in Ca2+ which leads to the essential insulin release.
View attachment IMG_2616.webp
What this would lead to is insulin would immediately get a demand signal from the Insulin receptor (IR) which already autophosphorylates upon binding.thid reaction causes mobilization of also IRS-1 and IRS-2.
This is where insulin’s main anabolic level comes in,the recruitment of both IR-1 and IR-2 causes a mass influx in PI3K which then contributes to PIP formation which essentially creates your final growth factor Akt which leads to further downstream effects. Akt is basically the central point of lots of downstream effects.
In terms of storing glycogen,GLUT4 which is triggered by Akt cause the GLUT4 vesicles to move to the membrane of the cell. Once it’s included into the membrane glucose floods that cell,glucose uptake into muscle increased 7~ folds in the matter of minutes due to this mechanism leading to the eventual “feeding” of glucose and storange of glycogen. Akt inhibits GSK-3 which triggered glycogen synthesis. Glycogen of a column of glucose connected by water,1g of glycogen holds about 3-4g of water.
Another nice thing about insulin is that it’s very anti catabolic,that’s why whenever someone says “I’m keto while cutting” Mandy finds them extremely stupid. What insulin does nicely is increases the activity the Amino acid transporter, indirectly keeps MTOR upregulated and prevents the general amino acid breakdown. When you want to get rid of fat the stupidest thing you could do is possibly go on no carbs, you are literally wasting muscle mass. Imsulin activates MTORC1 therefore increasing transition initiation and also increasing ribosomal activity. It also supresses proteolysis via inhibition of unibuitin-proteason pathway and simple autophagy.
Ever why eating carbs before a workout is ideal without the classic better efficiency of ATP? Mineral uptake,via ATPase and K+ and Na+ which support better motor nerve contraction,not by glucose oxidation but by Insulin itself. People like to say a low glycemic state is metabolically healthy,pretty false when you think of the elevated cortisol,poor thyroid conversion elevated free fatty acids.
Pretty fair to say that in conclusion,insulin is hella anabolic.
Fearmongering:Should you be scared of exogenous insulin?
A clear answer is absolutely not at all.
What do most people fear of insulin? HYPOGLYCEMIA. Now in terms Mandy,JFL if you’re scared of being hypoglycemic. People who get hypoglycemic while using insulin don’t know what the fuck they’re doing at all. First we have to fatal hypoglycemia cases.
Who dies from hypoglycemia? People who use an insulin pen and people who use a short acting insulin. Why does this play a difference? So you don’t make the same mistake! Many people die from simply misclicking their insulin pen,they misclick it to hundreds of IU’s unnoticed and them the person glucose depletes all at once and you’re instantly dead. What can you learn from that? Don’t use an insulin pen!, use a vial! With a vial you’ll have a more cleared and known dosage,you need precision to dose up which makes it better,IU per IU,you’ll know and unless you’re just a rock you can’t mess that up.
Also we talked about short acting insulins,that’s not what you need and that’s not what I recommend. What I do recommend is Lantus insulin,Insulin gargaline. If you saw my posts and advice before,you’ll constantly see me talk about “lantus insulin” so what is it? It’s a long acting insulin,unlike the short acting ones you only have to administer it only once a day compared to before every meal with a short acting one. What this offers is an almost non existent peak (no sudden or rapid hypoglycemia) and stable levels. Just once a day 30 minutes to 1 hour breakfast and then you’re ready for the day. Also you don’t need to worry about timing at all.
1x daily,in the morning,empty stomach,subcutaneous. When taken with GH,15-25IU is ideal.
Fuck,lots of work into this so I hope my effort gets appreciation so give reps thanks babes.
If you want advice personally
Tags:
Biomaxx
justnemat Also A Admincel give me contributor Saar
