Intro
Imo 90% of this forum could get laid if they were low inhib and put themself out there. It may sound cringe but the normie saying ‘just be confident bro’ is sorta right. That’s why low inhibition drugs are in my top 5 best looksmaxes.
Pregabalin
How it works/ biology
Pregabalin works by binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels, which reduces the release of excitatory neurotransmitters like glutamate, substance-P, and norepinephrine in the brain and spinal cord. This action calms the overactive neuronal pathways in anxiety.
Benefits
It's very orally bioavailable (around 90%, less affected by food etc).
Individual studies have shown a significant reduction in both the psychological and somatic symptoms of anxiety.
The study shows it cures 90% of anxiety
Looksmax.gg
Does pregabalin offer potential as a first-line therapy for generalized anxiety ...
However anecdotally the buzz/ high from pregab isn’t quite as good as something like alcohol
In addition it is quite liver friendly and has low liver toxicity
National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPregabalin - LiverTox
Due to its low amount of side effects it’s a good stacking drug as well
Side effects
A common side effect to pregablin is bloat/ water retention and weight , however this can be easily counter by a diuretic like furesomide or Epleronone and a glp 1 antagonist
Mayo Clinichttps://www.mayoclinic.orgPregabalin (oral route) - Side effects & dosage
Another is dizziness and drowsiness which isn’t too bad of a side effect and should probably be ignored
Drugs.comhttps://www.drugs.comDoes Lyrica (pregabalin) make you sleepy?
Could cause erectile dysfunction if you’re abusing it
https://pubmed.ncbi.nlm.nih.gov/30001248/#:~:text=Discontinuation of PGB resulted in,Young Adult
Dosage
Pregab takes about 1-3 hours to kick in and lasts for 5-7 hours.
You should take around 150-300 mg.
The long term use- it doesn’t really downregulate receptors compared to something like Phenibut but it still is quite addictive, that’s why you should only take it once or twice a week and lower doses.
Conclusion
In conclusion Pregablin is an all round good low inhib drug as it has small amount of side effects and its effectiveness. However should not be overused due to its withdrawal symptoms and should instead be used a maximum of 2 times a week.
Alcohol
How it works/ biology
Alcohol can provide temporary anxiety relief by affecting GABA and glutamate neurotransmitters, which calm the brain and slow its functions
Benefits
It makes you less anxious, however your fear won’t reduce. So it’s not as good as pregab
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcohol selectively reduces anxiety but not fear: Startle response during ...
It’s also very socially acceptable and you can even be encouraged to do it in public
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSocial and Cultural Contexts of Alcohol Use
It’s a diuretic, it’s a mild diuretic which can reduce water retention.
https://www.nidirect.gov.uk/article...text=There is no immediate way,Types of drink
Side effects
Reduces your gym gains
Looksmax.gg
Excessive alcohol use leads to liver toxicity
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcoholic Liver Disease: Pathogenesis and Current ...
Another is dizziness and drowsiness and getting drunk which can be a lookism in some cases
Alcoholism and Vertigo - Rehab Recovery
Long term use can cause erectile dysfunction
https://www.numan.com/erectile-dysf...ffects of alcohol,on your journey to recovery.
Dosage
Alcohol takes about 10 minutes to kick in and lasts for 12 hours
You should take around 6 standard units
The long term use- it initial alcohol consumption enhances inhibitory effects, but prolonged exposure leads to a decrease in receptor density or sensitivity. Similarly, alcohol consumption can lead to the down regulation of dopamine receptors which is linked to the development of alcohol use disorder. It’s quite addictive so I’d recommend using it as a one off like once a month.
Conclusion
In conclusion alcohol is a decent drug to lower inhibition however due to its side effects mainly the liver toxicity I’d recommend doing it infrequently especially if you’re roiding
Baclofen
How it works/ biology
Baclofen works for anxiety primarily by activating the brain's GABA-B receptors, which results in a calming effect on the central nervous system.
Benefits
It’s very bioavailable
In addition it’s been proven to make you less anxious
https://www.sciencedirect.com/science/article/abs/pii/S0924977X21001449
In addition anecdotal evidence has shown that the high/ buzz is similar to alcohol.
It’s also not liver toxic
Baclofen - LiverTox - NCBI Bookshelf
Side effects
It’s got extreme drowsiness effect that’s why you have to take something like caffeine pills to stay awake.
Mayo Clinichttps://www.mayoclinic.orgBaclofen (oral route) - Side effects & dosage
It also has a similar effect to being drunk so it could be awkward explaining why you’re acting this way to friends etc if you use it in the daytimes and not nights out.
Some people may experience erectile dysfunction
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSexual Dysfunction Associated With Intrathecal Baclofen Use: A Report ...
Dosage
Baclofen takes 1-2 hours to kick in and lasts for 2-4 hours
You should take 50 mg
The long term use- far less down-regulation and addiction potential compared with the other two compounds, you could potentially take it everyday if you wanted however I’d not recommend due to the side effect of acting drunk.
However it’s easy to overdose so keep the dosage on below 50 mg
In addition it’s got a weird synergy with pregab and they work reportedly insanely well together. However this is just anecdotal evidence and not being properly studied yet.
Conclusion
A good low inhib drug especially when combined with pregab. It would be a ‘safer’ alcohol alternative is used by its self. However I don’t recommend using unless on nights out due to it’s short time duration and adverse side effects
Propranolol
How it works/ biology
Propranolol is a non selective beta blocker that works by blocking the effects of adrenaline and noradrenaline on the heart and other organs, preventing them from binding to beta-1 and beta-2 adrenergic receptors. By blocking these receptors, propranolol slows the heart rate, decreases the force of heart contractions, and relaxes blood vessels, which lowers blood pressure and the heart's workload, leading to a reduction in the physical symptoms of the "fight-or-flight" response
Benefits
Extremely good at lowering anxiety
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govPropranolol for the treatment of anxiety disorders: Systematic review and ...
Very low liver toxicity
National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPropranolol - LiverTox
Side effects
headaches
Propranolol (oral route) - Side effects & dosage - Mayo Clinic
Dizziness
Propranolol (oral route) - Side effects & dosage - Mayo Clinic
cause erectile dysfunction (ED) in some men, although the relationship isn't always confirmed and may be dose-dependent, with higher doses potentially increasing risk
Looksmax.gg
Decreases blood pressure
Propranolol (oral route) - Side effects & dosage - Mayo Clinic
Dosage
Propranolol takes 1-2 hours to kick in and lasts for 8-12 hours
You should take 40 mg daily but take it in two doses (20mg x2) e.g. one in the morning other at lunch. For bets effect
The long term use-
it’s not addictive
Propranolol (Inderal) - MentalHealth.com
Because it doesn't interact with the brain's reward system, which is the primary mechanism behind addiction. Instead of creating pleasurable or euphoric feelings that drugs like cocaine or heroin do
Conclusion
If you have any signs of high inhib you should take propranolol twice a day unless you have low blood pressure and it’s a no brainer. It’s probably one of the most underrated looksmaxxing drug.
Phenibut
How it works/ biology
It’s a drug that reduces anxiety by acting as a depressant on the central nervous system. It is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is the brain's main inhibitory chemical. By mimicking and enhancing GABA's effects, phenibut decreases the overall excitability of nerve cells in the brain, inducing a sense of calm
Benefits
Improves mood
Phenibut: A Guide to History, Side Effects & Risk of Addiction
Works well in tandem with other low inhib drugs to extend the duration of their effects
Phenibut - Wikipedia
Side effects
Bad bioavailability
Wiley Online Libraryhttps://onlinelibrary.wiley.comPhenibut: A drug with one too many “buts”
Liver damage
https://balancerehabclinic.com/phen...endence: In the long,when not taking the drug.
Extreme withdrawal symptoms - most extreme on the list
Looksmax.gg
Dosage
Phenibut takes 1-2 hour to kick in and lasts for 15-24 hours
You should take 1-3 g
The long term use- Phenibut is biologically extremely addictive because it modifies key neural pathways, primarily by acting as a strong agonist for the inhibitory GABA-B receptors and blocking voltage-gated calcium channels (VGCCs). This neurochemical interference leads to physical dependence, rapid tolerance, and severe withdrawal symptoms upon cessation.
https://pmc.ncbi.nlm.nih.gov/articl...butyric acid) is,nausea/vomiting, and tremors.
Conclusion
Phenibut could’ve been very good because of its stacking abilite. However due to how toxic and addictive it is you should stay as far away from it as possible
Xanax
How it works/ biology
It works by binding to the benzodiazepine derivatives site on the GABA A receptor to enhance the affinity of channel opening by the agonist gamma-Aminobutyric acid (GABA), which leads to central nervous system depression
Benefits
Good bioavailability
Alprazolam - StatPearls - NCBI Bookshelf
Very good for anxiety (duh), it’s also the most powerful drug on the list
National Institutes of Health (NIH) | (.gov)https://pubmed.ncbi.nlm.nih.govAlprazolam in the treatment of generalized anxiety and panic ...
Side effects
Harmful to the liver (not as much as alcohol though)
https://www.ncbi.nlm.nih.gov/books/...monly associated,their lack of hepatic injury.
Can’t be stacked as it makes it dependence greater
https://blackbearrehab.com/substanc...ties, unconsciousness and unintentional death.
Drowsiness and fatigue and similar (but less severe effects as being drunk)
https://www.healthline.com/health/d... is a mild side,some people may have diarrhea.
Erectile dysfunction is possible
https://www.healthline.com/health/d... is a mild side,some people may have diarrhea.
Dosage
Xanax takes just under an hour to kick in and lasts for 8 hours
You should take 0.5-1.0 mg
The long term use- downregulation and desensitization ofGABA-A receptors with chronic use, where the brain reduces the number of available receptors to compensate for the drug's presence. This adaptive process contributes to the development of tolerance, where higher doses are needed for the same effect, and is a key mechanism in benzodiazepine
Conclusion
Although Xanax probably is the most effective drug to lower inhibition in this thread it’s downsides like how it’s highly addictive vastly outweighs the slight upsides that is why I wouldn’t recommend Xanax
Conclusion
You should take propranolol twice a day (2x 20 mg) in addition to a combination of 150-300 mg of Pregabalin with 50 mg Baclofen before a big event but only a maximum of twice a week. If you can’t get anything else and are stuck with only being able to use alcohol you should use it but try to do so as infrequently as possible
Imo 90% of this forum could get laid if they were low inhib and put themself out there. It may sound cringe but the normie saying ‘just be confident bro’ is sorta right. That’s why low inhibition drugs are in my top 5 best looksmaxes.
Pregabalin
How it works/ biology
Pregabalin works by binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels, which reduces the release of excitatory neurotransmitters like glutamate, substance-P, and norepinephrine in the brain and spinal cord. This action calms the overactive neuronal pathways in anxiety.
Benefits
It's very orally bioavailable (around 90%, less affected by food etc).
Individual studies have shown a significant reduction in both the psychological and somatic symptoms of anxiety.
The study shows it cures 90% of anxiety
Looksmax.gg
Does pregabalin offer potential as a first-line therapy for generalized anxiety ...
However anecdotally the buzz/ high from pregab isn’t quite as good as something like alcohol
In addition it is quite liver friendly and has low liver toxicity
National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPregabalin - LiverTox
Due to its low amount of side effects it’s a good stacking drug as well
Side effects
A common side effect to pregablin is bloat/ water retention and weight , however this can be easily counter by a diuretic like furesomide or Epleronone and a glp 1 antagonist
Mayo Clinichttps://www.mayoclinic.orgPregabalin (oral route) - Side effects & dosage
Another is dizziness and drowsiness which isn’t too bad of a side effect and should probably be ignored
Drugs.comhttps://www.drugs.comDoes Lyrica (pregabalin) make you sleepy?
Could cause erectile dysfunction if you’re abusing it
https://pubmed.ncbi.nlm.nih.gov/30001248/#:~:text=Discontinuation of PGB resulted in,Young Adult
Dosage
Pregab takes about 1-3 hours to kick in and lasts for 5-7 hours.
You should take around 150-300 mg.
The long term use- it doesn’t really downregulate receptors compared to something like Phenibut but it still is quite addictive, that’s why you should only take it once or twice a week and lower doses.
Conclusion
In conclusion Pregablin is an all round good low inhib drug as it has small amount of side effects and its effectiveness. However should not be overused due to its withdrawal symptoms and should instead be used a maximum of 2 times a week.
Alcohol
How it works/ biology
Alcohol can provide temporary anxiety relief by affecting GABA and glutamate neurotransmitters, which calm the brain and slow its functions
Benefits
It makes you less anxious, however your fear won’t reduce. So it’s not as good as pregab
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcohol selectively reduces anxiety but not fear: Startle response during ...
It’s also very socially acceptable and you can even be encouraged to do it in public
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSocial and Cultural Contexts of Alcohol Use
It’s a diuretic, it’s a mild diuretic which can reduce water retention.
https://www.nidirect.gov.uk/article...text=There is no immediate way,Types of drink
Side effects
Reduces your gym gains
Looksmax.gg
Excessive alcohol use leads to liver toxicity
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcoholic Liver Disease: Pathogenesis and Current ...
Another is dizziness and drowsiness and getting drunk which can be a lookism in some cases
Alcoholism and Vertigo - Rehab Recovery
Long term use can cause erectile dysfunction
https://www.numan.com/erectile-dysf...ffects of alcohol,on your journey to recovery.
Dosage
Alcohol takes about 10 minutes to kick in and lasts for 12 hours
You should take around 6 standard units
The long term use- it initial alcohol consumption enhances inhibitory effects, but prolonged exposure leads to a decrease in receptor density or sensitivity. Similarly, alcohol consumption can lead to the down regulation of dopamine receptors which is linked to the development of alcohol use disorder. It’s quite addictive so I’d recommend using it as a one off like once a month.
Conclusion
In conclusion alcohol is a decent drug to lower inhibition however due to its side effects mainly the liver toxicity I’d recommend doing it infrequently especially if you’re roiding
Baclofen
How it works/ biology
Baclofen works for anxiety primarily by activating the brain's GABA-B receptors, which results in a calming effect on the central nervous system.
Benefits
It’s very bioavailable
In addition it’s been proven to make you less anxious
https://www.sciencedirect.com/science/article/abs/pii/S0924977X21001449
In addition anecdotal evidence has shown that the high/ buzz is similar to alcohol.
It’s also not liver toxic
Baclofen - LiverTox - NCBI Bookshelf
Side effects
It’s got extreme drowsiness effect that’s why you have to take something like caffeine pills to stay awake.
Mayo Clinichttps://www.mayoclinic.orgBaclofen (oral route) - Side effects & dosage
It also has a similar effect to being drunk so it could be awkward explaining why you’re acting this way to friends etc if you use it in the daytimes and not nights out.
Some people may experience erectile dysfunction
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSexual Dysfunction Associated With Intrathecal Baclofen Use: A Report ...
Dosage
Baclofen takes 1-2 hours to kick in and lasts for 2-4 hours
You should take 50 mg
The long term use- far less down-regulation and addiction potential compared with the other two compounds, you could potentially take it everyday if you wanted however I’d not recommend due to the side effect of acting drunk.
However it’s easy to overdose so keep the dosage on below 50 mg
In addition it’s got a weird synergy with pregab and they work reportedly insanely well together. However this is just anecdotal evidence and not being properly studied yet.
Conclusion
A good low inhib drug especially when combined with pregab. It would be a ‘safer’ alcohol alternative is used by its self. However I don’t recommend using unless on nights out due to it’s short time duration and adverse side effects
Propranolol
How it works/ biology
Propranolol is a non selective beta blocker that works by blocking the effects of adrenaline and noradrenaline on the heart and other organs, preventing them from binding to beta-1 and beta-2 adrenergic receptors. By blocking these receptors, propranolol slows the heart rate, decreases the force of heart contractions, and relaxes blood vessels, which lowers blood pressure and the heart's workload, leading to a reduction in the physical symptoms of the "fight-or-flight" response
Benefits
Extremely good at lowering anxiety
National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govPropranolol for the treatment of anxiety disorders: Systematic review and ...
Very low liver toxicity
National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPropranolol - LiverTox
Side effects
headaches
Propranolol (oral route) - Side effects & dosage - Mayo Clinic
Dizziness
Propranolol (oral route) - Side effects & dosage - Mayo Clinic
cause erectile dysfunction (ED) in some men, although the relationship isn't always confirmed and may be dose-dependent, with higher doses potentially increasing risk
Looksmax.gg
Decreases blood pressure
Propranolol (oral route) - Side effects & dosage - Mayo Clinic
Dosage
Propranolol takes 1-2 hours to kick in and lasts for 8-12 hours
You should take 40 mg daily but take it in two doses (20mg x2) e.g. one in the morning other at lunch. For bets effect
The long term use-
it’s not addictive
Propranolol (Inderal) - MentalHealth.com
Because it doesn't interact with the brain's reward system, which is the primary mechanism behind addiction. Instead of creating pleasurable or euphoric feelings that drugs like cocaine or heroin do
Conclusion
If you have any signs of high inhib you should take propranolol twice a day unless you have low blood pressure and it’s a no brainer. It’s probably one of the most underrated looksmaxxing drug.
Phenibut
How it works/ biology
It’s a drug that reduces anxiety by acting as a depressant on the central nervous system. It is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is the brain's main inhibitory chemical. By mimicking and enhancing GABA's effects, phenibut decreases the overall excitability of nerve cells in the brain, inducing a sense of calm
Benefits
Improves mood
Phenibut: A Guide to History, Side Effects & Risk of Addiction
Works well in tandem with other low inhib drugs to extend the duration of their effects
Phenibut - Wikipedia
Side effects
Bad bioavailability
Wiley Online Libraryhttps://onlinelibrary.wiley.comPhenibut: A drug with one too many “buts”
Liver damage
https://balancerehabclinic.com/phen...endence: In the long,when not taking the drug.
Extreme withdrawal symptoms - most extreme on the list
Looksmax.gg
Dosage
Phenibut takes 1-2 hour to kick in and lasts for 15-24 hours
You should take 1-3 g
The long term use- Phenibut is biologically extremely addictive because it modifies key neural pathways, primarily by acting as a strong agonist for the inhibitory GABA-B receptors and blocking voltage-gated calcium channels (VGCCs). This neurochemical interference leads to physical dependence, rapid tolerance, and severe withdrawal symptoms upon cessation.
https://pmc.ncbi.nlm.nih.gov/articl...butyric acid) is,nausea/vomiting, and tremors.
Conclusion
Phenibut could’ve been very good because of its stacking abilite. However due to how toxic and addictive it is you should stay as far away from it as possible
Xanax
How it works/ biology
It works by binding to the benzodiazepine derivatives site on the GABA A receptor to enhance the affinity of channel opening by the agonist gamma-Aminobutyric acid (GABA), which leads to central nervous system depression
Benefits
Good bioavailability
Alprazolam - StatPearls - NCBI Bookshelf
Very good for anxiety (duh), it’s also the most powerful drug on the list
National Institutes of Health (NIH) | (.gov)https://pubmed.ncbi.nlm.nih.govAlprazolam in the treatment of generalized anxiety and panic ...
Side effects
Harmful to the liver (not as much as alcohol though)
https://www.ncbi.nlm.nih.gov/books/...monly associated,their lack of hepatic injury.
Can’t be stacked as it makes it dependence greater
https://blackbearrehab.com/substanc...ties, unconsciousness and unintentional death.
Drowsiness and fatigue and similar (but less severe effects as being drunk)
https://www.healthline.com/health/d... is a mild side,some people may have diarrhea.
Erectile dysfunction is possible
https://www.healthline.com/health/d... is a mild side,some people may have diarrhea.
Dosage
Xanax takes just under an hour to kick in and lasts for 8 hours
You should take 0.5-1.0 mg
The long term use- downregulation and desensitization ofGABA-A receptors with chronic use, where the brain reduces the number of available receptors to compensate for the drug's presence. This adaptive process contributes to the development of tolerance, where higher doses are needed for the same effect, and is a key mechanism in benzodiazepine
Conclusion
Although Xanax probably is the most effective drug to lower inhibition in this thread it’s downsides like how it’s highly addictive vastly outweighs the slight upsides that is why I wouldn’t recommend Xanax
Conclusion
You should take propranolol twice a day (2x 20 mg) in addition to a combination of 150-300 mg of Pregabalin with 50 mg Baclofen before a big event but only a maximum of twice a week. If you can’t get anything else and are stuck with only being able to use alcohol you should use it but try to do so as infrequently as possible
