Looksmax - Men's Self Improvement Forum

Welcome to the ultimate men’s self-improvement community where like-minded individuals come together to level up every aspect of their lives. Whether it’s building confidence, improving your mindset, optimizing health, or mastering aesthetics, this is the place to become the best version of yourself. Join the hood and start your transformation today.
  • Register to unlock full access to the community including active real-time chats, free exclusive courses, and best of the best forum.

GH peptides explained and ranked in depth
Joined
Oct 7, 2025
Posts
1
Reputation
1
What are “GH secretagogous/peptides”?


Growth hormone secretagogues are compounds (peptides or non-peptidic) that stimulate the release of growth hormone from the pituitary, rather than being exogenous GH in of itself.


They commonly act by binding to the growth hormone secretagogue receptor (GHS-R), which is also the receptor for ghrelin, or by acting on the GHRH axis.


Because they stimulate endogenous GH release, they tend to maintain the feedback loops (somatostatin, IGF-1) more naturally than exogenous GH which is safer than exogenous GH. However these are less effective than something like HGH because there is a cap to how much they can stimulate but you can shoot up as much HGH as you want.














TypeExamplesMechanism
GHRH analogs / GHRH-derived peptidesSermorelin, CJC-1295 (with or without DAC), Modified GRF(1-29)These are analogues of GHRH. They stimulate GH release via the GHRH receptor (GHRH-R) on pituitary somatotrophs.
GHRPs (growth hormone releasing peptides)GHRP-1, GHRP-2,, GHRP-3, GHRP-4, GHRP-5 GHRP-6, HexarelinSmall synthetic peptides usually 6-7 amino acids (not making a 67 joke, it's actually 6-7) that act with the GHS-R / ghrelin receptor pathway to stimulate GH release.
Non-peptidic / peptidomimetic secretagoguesIbutamoren (MK-677), Macimorelin, Ipamorelin (though ipamorelin is a peptide)These are small molecules (or peptide mimetics) that stimulate GH release.


When ranking these were the factors I used.


  • Potency (how much they raise GH / IGF-1)

  • Duration / half-life (how long effect lasts)

  • Specificity / side effects (how many off-target effects)

  • Ease of administration (oral vs injectable, frequency)

  • Safety / tolerance / long-term data

  • Use case (fat loss, anti-aging, muscle gain, etc.)







Ipamorelin with Cjc-1295 (no DAC)Often favored for having fewer side effects (less impact on cortisol, prolactin) while still stimulating GH. Still short half-life, requires frequent dosing, limited long-term human trials.
CJC-1295 (with DAC)Long-acting GHRH analog. Provides more sustained GH elevation with fewer peaks and troughs. [oai_citation:8‡TRTMD
Sermorelin / Modified GRF(1-29)One of the better-known GHRH analogs, reasonably safe, decent track record. Modified GRF(1-29) improves half-life over native GHRH fragment.







GHRP-6Classic, well-studied GHRP. Solid GH release in many studies. Tends to increase appetite (ghrelin effect), possible cortisol / prolactin rise, insensitivity over time
GHRP-2Some consider it more potent than GHRP-6 with possibly fewer side effects. Same issues: short half-life, frequent dosing, limited data
HexarelinVery strong GH releaser More side effects (cardiac / prolactin / desensitization) in some reports
 

0psl75iq

I am a normal person
Joined
Oct 5, 2025
Posts
73
Reputation
112
DNR but bumping anyways
 

yuxun

Iron
Joined
Oct 7, 2025
Posts
37
Reputation
29
What are “GH secretagogous/peptides”?


Growth hormone secretagogues are compounds (peptides or non-peptidic) that stimulate the release of growth hormone from the pituitary, rather than being exogenous GH in of itself.


They commonly act by binding to the growth hormone secretagogue receptor (GHS-R), which is also the receptor for ghrelin, or by acting on the GHRH axis.


Because they stimulate endogenous GH release, they tend to maintain the feedback loops (somatostatin, IGF-1) more naturally than exogenous GH which is safer than exogenous GH. However these are less effective than something like HGH because there is a cap to how much they can stimulate but you can shoot up as much HGH as you want.














TypeExamplesMechanism
GHRH analogs / GHRH-derived peptidesSermorelin, CJC-1295 (with or without DAC), Modified GRF(1-29)These are analogues of GHRH. They stimulate GH release via the GHRH receptor (GHRH-R) on pituitary somatotrophs.
GHRPs (growth hormone releasing peptides)GHRP-1, GHRP-2,, GHRP-3, GHRP-4, GHRP-5 GHRP-6, HexarelinSmall synthetic peptides usually 6-7 amino acids (not making a 67 joke, it's actually 6-7) that act with the GHS-R / ghrelin receptor pathway to stimulate GH release.
Non-peptidic / peptidomimetic secretagoguesIbutamoren (MK-677), Macimorelin, Ipamorelin (though ipamorelin is a peptide)These are small molecules (or peptide mimetics) that stimulate GH release.


When ranking these were the factors I used.


  • Potency (how much they raise GH / IGF-1)

  • Duration / half-life (how long effect lasts)

  • Specificity / side effects (how many off-target effects)

  • Ease of administration (oral vs injectable, frequency)

  • Safety / tolerance / long-term data

  • Use case (fat loss, anti-aging, muscle gain, etc.)







Ipamorelin with Cjc-1295 (no DAC)Often favored for having fewer side effects (less impact on cortisol, prolactin) while still stimulating GH. Still short half-life, requires frequent dosing, limited long-term human trials.
CJC-1295 (with DAC)Long-acting GHRH analog. Provides more sustained GH elevation with fewer peaks and troughs. [oai_citation:8‡TRTMD
Sermorelin / Modified GRF(1-29)One of the better-known GHRH analogs, reasonably safe, decent track record. Modified GRF(1-29) improves half-life over native GHRH fragment.







GHRP-6Classic, well-studied GHRP. Solid GH release in many studies.Tends to increase appetite (ghrelin effect), possible cortisol / prolactin rise, insensitivity over time
GHRP-2Some consider it more potent than GHRP-6 with possibly fewer side effects.Same issues: short half-life, frequent dosing, limited data
HexarelinVery strong GH releaserMore side effects (cardiac / prolactin / desensitization) in some reports
WE will be reading this
 
Joined
Oct 12, 2025
Posts
10
Reputation
13
What are “GH secretagogous/peptides”?


Growth hormone secretagogues are compounds (peptides or non-peptidic) that stimulate the release of growth hormone from the pituitary, rather than being exogenous GH in of itself.


They commonly act by binding to the growth hormone secretagogue receptor (GHS-R), which is also the receptor for ghrelin, or by acting on the GHRH axis.


Because they stimulate endogenous GH release, they tend to maintain the feedback loops (somatostatin, IGF-1) more naturally than exogenous GH which is safer than exogenous GH. However these are less effective than something like HGH because there is a cap to how much they can stimulate but you can shoot up as much HGH as you want.














TypeExamplesMechanism
GHRH analogs / GHRH-derived peptidesSermorelin, CJC-1295 (with or without DAC), Modified GRF(1-29)These are analogues of GHRH. They stimulate GH release via the GHRH receptor (GHRH-R) on pituitary somatotrophs.
GHRPs (growth hormone releasing peptides)GHRP-1, GHRP-2,, GHRP-3, GHRP-4, GHRP-5 GHRP-6, HexarelinSmall synthetic peptides usually 6-7 amino acids (not making a 67 joke, it's actually 6-7) that act with the GHS-R / ghrelin receptor pathway to stimulate GH release.
Non-peptidic / peptidomimetic secretagoguesIbutamoren (MK-677), Macimorelin, Ipamorelin (though ipamorelin is a peptide)These are small molecules (or peptide mimetics) that stimulate GH release.


When ranking these were the factors I used.


  • Potency (how much they raise GH / IGF-1)

  • Duration / half-life (how long effect lasts)

  • Specificity / side effects (how many off-target effects)

  • Ease of administration (oral vs injectable, frequency)

  • Safety / tolerance / long-term data

  • Use case (fat loss, anti-aging, muscle gain, etc.)







Ipamorelin with Cjc-1295 (no DAC)Often favored for having fewer side effects (less impact on cortisol, prolactin) while still stimulating GH. Still short half-life, requires frequent dosing, limited long-term human trials.
CJC-1295 (with DAC)Long-acting GHRH analog. Provides more sustained GH elevation with fewer peaks and troughs. [oai_citation:8‡TRTMD
Sermorelin / Modified GRF(1-29)One of the better-known GHRH analogs, reasonably safe, decent track record. Modified GRF(1-29) improves half-life over native GHRH fragment.







GHRP-6Classic, well-studied GHRP. Solid GH release in many studies.Tends to increase appetite (ghrelin effect), possible cortisol / prolactin rise, insensitivity over time
GHRP-2Some consider it more potent than GHRP-6 with possibly fewer side effects.Same issues: short half-life, frequent dosing, limited data
HexarelinVery strong GH releaserMore side effects (cardiac / prolactin / desensitization) in some reports
Mirin thread but exogenous HGH will always be better yeah its less safe but it relies less on your genes if your genes dont allow you to produce a lot of HGH your body will release a lot of somatostatin to counter the excess and high hgh levels in the body so hgh peptides will only give you a slightly higher edge than someone who is natural and you can't inhibit somatostatin because it has very bad and regretful side effects so exogenous HGH is better because it bypass the feed back loop so no somatostatin is released and the side effects can be inhibited with berberine and a lower dose(lower than 8-7 ius is safe) peptides are good if you have good genes and cant source cheap good HGH me personally i have a good source for pharma grade HGH lab tested
 
Activity
So far there's no one here

Users who are viewing this thread

shape1
shape2
shape3
shape4
shape5
shape6
Top